Recent publications
Article
Webster, JM, Waaijenberg, K, van de Worp, WRPH, Kelders, MCJM, Lambrichts, S, Martin, C, Verhaegen, F, Van der Heyden, B, Smith, C, Lavery, GG, Schols, AMWJ, Hardy, RS & Langen, RCJ 2023, '11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD', American journal of physiology. Lung cellular and molecular physiology, vol. 324, no. 4, pp. L400-L412. https://doi.org/10.1152/ajplung.00009.2022
O’Neil, JD, Bolimowska, OO, Clayton, SA, Tang, T, Daley, KK, Lara-Reyna, S, Warner, J, Martin, CS, Mahida, RY, Hardy, RS, Arthur, JSC & Clark, AR 2023, 'Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β', Frontiers in immunology, vol. 14, 1190261. https://doi.org/10.3389/fimmu.2023.1190261
Hansen, MS, Søe, K, Christensen, LL, Fernandez-Guerra, P, Hansen, NW, Wyatt, RA, Martin, C, Hardy, RS, Andersen, TL, Olesen, JB, Hartmann, B, Rosenkilde, MM, Kassem, M, Rauch, A, Gorvin, C & Frost, M 2023, 'GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells', European Journal of Endocrinology , vol. 188, no. 1, lvac004. https://doi.org/10.1093/ejendo/lvac004
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Favero, V, Prete, A, Mangone, A, Elhassan, Y, Pucino, V, Asia, M, Hardy, R, Chiodini, I & Ronchi, C 2023, 'Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study', European Journal of Endocrinology, vol. 183, lvad151, pp. 517-526. https://doi.org/10.1093/ejendo/lvad151
Merk, VM, Phan, TS, Wiedmann, A, Hardy, RS, Lavery, GG & Brunner, T 2023, 'Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice', Frontiers in immunology, vol. 14, 1252874. https://doi.org/10.3389/fimmu.2023.1252874
Fenton, CG, Crastin, A, Martin, CS, Suresh, S, Montagna, I, Hussain, B, Naylor, AJ, Jones, SW, Hansen, MS, Gorvin, CM, Price, M, Filer, A, Cooper, MS, Lavery, GG, Raza, K & Hardy, RS 2022, '11β-hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation', International Journal of Molecular Sciences, vol. 23, no. 13, 7334, pp. 7334. https://doi.org/10.3390/ijms23137334
Siddiqa, A, Tajammal, A, Irfan, A, Azam, M, Munawar, MA, Hardy, RS & Asim Raza Basra, M 2022, 'Synthesis, molecular docking, bio-evaluation and quantitative structure activity relationship of new chalcone derivatives as antioxidants', Journal of Molecular Structure. https://doi.org/10.1016/j.molstruc.2022.134814
Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Hardy, RS, Lavery, GG, Matthay, MA, Naidu, B, Perkins, GD & Thickett, DR 2021, 'Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis', The European respiratory journal, vol. 58, no. 3, 2100829. https://doi.org/10.1183/13993003.00829-2021
Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Belchamber, KBR, Hardy, RS, Matthay, MA, Naidu, B & Thickett, DR 2021, 'Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome', Frontiers in Medicine, vol. 8, 737859. https://doi.org/10.3389/fmed.2021.737859
Review article
Chidomere, CI, Wahid, M, Kemble, S, Chadwick, C, Thomas, R, Hardy, RS, Mcgettrick, HM & Naylor, AJ 2023, 'Bench to Bedside: Modelling Inflammatory Arthritis', Discovery Immunology, vol. 2, no. 1, kyac010. https://doi.org/10.1093/discim/kyac010
Sagmeister, M, Harper, L & Hardy, R 2023, 'Cortisol excess in chronic kidney disease: – a review of changes and impact on mortality', Frontiers in Endocrinology, vol. 13, 1075809. https://doi.org/10.3389/fendo.2022.1075809
Nicholson, TA, Sagmeister, M, Wijesinghe, SN, Farah, H, Hardy, RS & Jones, SW 2023, 'Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges', Pharmaceutics, vol. 15, no. 1, 237. https://doi.org/10.3390/pharmaceutics15010237
Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2021, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 174-187. https://doi.org/10.1210/clinem/dgaa766
Martin, CS, Cooper, MS & Hardy, RS 2021, 'Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe', Frontiers in Endocrinology, vol. 12, 733611. https://doi.org/10.3389/fendo.2021.733611
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