Dr Zaki Hassan-Smith MBBS, BMedSci(Hons), MRCP, PhD

Dr Zaki Hassan-Smith

Institute of Metabolism and Systems Research
Clinical Lecturer

Contact details

+44 (0)121 415 8811
+44 (0)121 415 8712
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Zaki Hassan-Smith is a Clinical Lecturer and Honorary Specialist Registrar in Endocrinology. His clinical interests are in Pituitary and Adrenal disease. His research interests, developed under supervision of Prof Paul Stewart, centre around the long-term effects of glucocorticoids in ageing and diseases such as sarcopenia and obesity. He was awarded the Society for Endocrinology Young Endocrinologist prize for top scoring oral communication at the British Endocrine Society Meeting in 2013. Prior to his current post, he was a European Research Council funded Clinical Research Fellow, an NIHR Academic Clinical Fellow and Specialty Registrar at UHB. He completed his Senior House Officer rotation at St Bartholomew’s and the Royal London Hospitals where he obtained his MRCP. He was House Officer in the Dept of Endocrinology at St. Bart’s and he completed an intercalated BMedSci project under the Supervision of Profs Marta Korbonits and Ashley Grossman.


  • Member of the Royal College of Physicians (MRCP)
  • MBBS
  • BMedSci(Hons)
  • Medical Education Post-Graduate Award
  • PhD
  • Speciality Certificate Examination in Endocrinology and Diabetes awarded by the Royal College of Physicians


Dr Hassan-Smith completed a Medical Education Post-Graduate Award at Warwick University in 2009, and has taken an active interest in teaching in the following areas at the University of Birmingham:

  • SGT Adrenal, Reproductive, Pituitary, Calcium/Bone Modules MBChB
  • Endocrinology of Ageing Lecture BMedSci
  • Glucocorticoid metabolizing enzymes and skeletal ageing BClinSci Lecture 
  • Supervisor SSM 4th Year MBChB students: Use of Corticosteroids
  • BDS (Dentistry) - Computer Practicals on Adrenals/Diabetes MPharm - SGT and Lectures


Featured Research Projects

  1. Gender and Age Specific Differences in Adipose Tissue Metabolism with Human Ageing 2. Using unbiased approaches to investigate Human Ageing and Sarcopenia.
  2. PhD Thesis: Glucocorticoids, 11ß-HSD1, and the Aged Phenotype, 2010-13.
  3. Long-term Outcomes of Cushing’s Disease treated with Trans-Sphenoidal Surgery 2009-2012.
  4. 11ß-HSD1 as the major regulator of tissue specific effects of glucocorticoid excess 6. mCPP and Appetite Study. Medical co-investigator, 2011-2013.
  5. Life-threatening complications of thyroidectomy study, 2005.
  6. Ghrelin receptor gene polymorphisms and body size, 2003-8.
  7. Polymorphisms in the GHRH receptor and body size study, 2003-4.

Pharmaceutical Research Projects

  1. European Adrenal Insufficiency Registry (EU-AIR). Site Investigator UHB NHS FT, 2012-13.
  2. OSI-906 a Novel Treatment for Adrenocortical carcinoma. Site Investigator 2010.

Other activities

Honorary SpR at UHB

Organiser of UHB Endocrine Clinical Cases Meetings 2011-2013

Public engagement:

  • Dr Hassan-Smith sat on the Voice of the Future Special Select Committee at the Houses of Parliament in 2014 and 2015 - where he asked questions to Shadow Universities Minister Liam Byrne and the Science Technology Select Committee.
  • He is a Member of Sense About Science and received a Grant from the Society for Endocrinology to attend their Media Training Workshop.
  • He contributed to the 'How Old Are You?' Event at the British Science Festival in 2014.
  • ‘You and Your Hormones’ SfE Public Information Website – Contributor/Peer Reviewer 2012-Present


  • King's Fund Aspiring Leaders
  • European Post-Graduate Pituitary Training (EUROPIT) Academy of Medical Sciences Career Development Imperial Insulin Pump Heart of England Retinal Screening Advanced Life Support


Hassan-Smith ZK, Morgan SA, Sherlock M, Hughes B, Taylor AE, Lavery GG, Tomlinson JW and Stewart PM (2015) Gender specific differences in skeletal muscle 11β-HSD1 expression across healthy ageing. J Clin Endocrinol Metab [Epub ahead of print]

Morgan SA, McCabe EL, Gathercole LL, Hassan-Smith ZK, Larner DP, Bujalska IJ, Stewart PM, Tomlinson JW and Lavery GG (2014) 11β-HSD1 is the major regulator of the tissue specific effects of circulating glucocorticoid excess. Proc Natl Acad Sci U S A 111(24):E2482-91

Thomas JM, Dourish CT, Tomlinson JW, Hassan-Smith Z and Higgs S (2014) Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers. Psychopharmacology (Berl) 231(12):2449-59

Tiganescu A, Tahrani AA, Morgan SA, Otranto M, Desmoulière A, Abrahams L, Hassan-Smith Z, Walker EA, Rabbitt EH, Cooper MS, Amrein K, Lavery GG and Stewart PM (2013) 11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest 123(7):3051-60

Hassan-Smith ZK, Sherlock M, Reulen RC, Arlt W, Ayuk J, Toogood AA, Cooper MS, Johnson AP and Stewart PM (2012) Outcome of Cushing’s disease following transphenoidal surgery in a single center over 20 years. J Clin Endocrinol Metab 97(4):1194-201

Hassan-Smith Z and Cooper MS (2011) Overview of the endocrine response to critical illness: how to measure it and when to treat. Best Pract Res Clin Endocrinol Metab 25(5):705-17

Hassan-Smith Z and Stewart PM (2011) Inherited forms of mineralocorticoid hypertension. Curr Opin Endocrinol Diabetes Obes 18(3):177-85

Hassan-Smith ZK, Gopinath P and Mihaimeed F (2011) A UK-Wide Survey of Life-threatening Thyroidectomy Complications. J Thyroid Res 2011:329620