Professor Tarekegn G Hiwot

Photograph of Dr Tarek Hiwot

Institute of Metabolism and Systems Research
Honorary Professor

Contact details

Telephone
+44 (0)121 371 6982
Email
t.g.hiwot@bham.ac.uk
Secondary Email
tarekegn.hiwot@uhb.nhs.uk
Address
Institute of Metabolism and Systems Research

Career History

  • 2016 - Honorary Reader, Institute of Metabolism and Systems Research, UoB
  • 2012 - Honorary Senior Research Fellow, University of Birmingham
  • 2008 - Consultant in Inherited Metabolic Disorders, UHB NHS FT
  • 2000-7 - Chemical Pathology/Metabolic Medicine (SHO/Registrar), West midlands
  • 1995-2000 - PhD , Molecular Immunology, Karolinska Institute, Sweden
  • 1994-95 - MSc, Biochemistry, Karolinska Institute, Sweden
  • 1990-93 - General practitioners, Addis Ababa, Ethiopia
  • 1989 - MD, Addis Ababa University, Ethiopia

Research

Tarek's group focuses on the deep phenotyping of rare inherited metabolic disorders to provide the best available care for each patient based on stratification into disease subclasses with a common biological basis. They utilise metabolomics, exome sequencing, novel biomarkers and international patient registries to understand the heterogeneity of diseases caused by single gene defect. Their main disease research area of interests are; Niemann-Pick, Fabry, Gaucher, Mucopolysaccharidosis, Alstrom syndrome and Phenylketonuria. 

Group members  

  • Clinical Fellow: Shanat Baig      
  • PhD Students: Fahad Al-Harbi 
  • Research Nurse: Vishy Veeranna   
  • Research coordinator: Shaun Bolton 

Major external collaborators

  • Jeremy Tomlinson (Oxford)
  • Paul Gissen (UCL)
  • Bruno Bembi (University of Udine, Italy)
  • Sandra Sirrs (Vancouver, Canada)
  • Derralynn Hughes (UCL)

Publications

Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome.

Gathercole LL, Hazlehurst JM, Armstrong MJ, Crowley R, Boocock S, O'Reilly MW, Round M, Brown R, Bolton S, Cramb R, Newsome PN, Semple RK, Paisey R, Tomlinson JW, Geberhiwot T.  Liver Int. 2016 Nov;36(11):1704-1712. doi: 10.1111/liv.13163.

A Novel Rapid MALDI-TOF-MS-Based Method for Measuring Urinary Globotriaosylceramide in Fabry Patients. Alharbi FJ, Geberhiwot T, Hughes DA, Ward DG. J Am Soc Mass Spectrom. 2016 Apr;27(4):719-25. doi: 10.1007/s13361-015-1318-4.

 High quality, patient centred and coordinated care for Alstrom syndrome: a model of care for an ultra-rare disease. Van Groenendael S, Giacovazzi L, Davison F, Holtkemper O, Huang Z, Wang Q, Parkinson K, Barrett T, Geberhiwot T.  Orphanet J Rare Dis. 2015 Nov 24;10:149. doi: 10.1186/s13023-015-0366-y.

 Diffuse left ventricular interstitial fibrosis is associated with sub-clinical myocardial dysfunction in Alström Syndrome: an observational study. Edwards NC, Moody WE, Yuan M, Warfield AT, Cramb R, Paisey RB, Geberhiwot T, Steeds RP.  Orphanet J Rare Dis. 2015 Jun 24;10:83. doi: 10.1186/s13023-015-0292-z.

 Duration of Diabetes Predicts Aortic Pulse Wave Velocity and Vascular Events in Alström Syndrome. Paisey RB, Smith J, Carey C, Barrett T, Campbell F, Maffei P, Marshall JD, Paisey C, Steeds RP, Edwards NC, Bunce S, Geberhiwot T.  J Clin Endocrinol Metab. 2015 Aug;100(8):E1116-24. doi: 10.1210/jc.2015-1577.