Dr Andrea Mitchell BSc, PhD

Image of Andrea Mitchell

Institute of Microbiology and Infection
Research Fellow

Contact details

Telephone
+44 (0)121 415 8758
Email
a.m.mitchell@bham.ac.uk
Address
Room S114 Biosciences Building
Institute of Microbiology and Infection & Centre for Human Virology
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Qualifications

  • PhD Human Molecular Genetics
  • DipRCPath
  • BSc Biological Sciences

Biography

Andrea Mitchell received her BSc from the University of Sussex, UK, then went on to work with Professor Graham Boulnois at the University of Leicester on a pneumococcal genetics project. After taking up a post as Clinical Scientist in the West Midlands Regional Genetic Service, Birmingham UK, she subsequently moved to the University of Glasgow where she completed her PhD using whole genome screening to identify genes implicated in Muscular Dystrophy. Following a career break, post-doctoral training continued in both virology and then bacteriology groups in the Institute of Infection, Immunity and Inflammation at the University of Glasgow. Now having moved to the Institute of Microbiology and Infection, Birmingham UK, she is particularly interested in working at the interface of bioinformatics and laboratory based research into host-pathogen interaction.

Teaching

  • BMedSci - 1st & 2nd year - tutor for small group teaching sessions
  • MSc Microbiology and Infection – Genomics lectures

Postgraduate supervision

  • Currently jointly supervise 1 PhD student

Research

Investigating host interaction of Streptococcus pneumoniae and other streptococcal species using comparative genomics and bioinformatics together with biological assays especially infection models. In part her work focusses on the genomics of related streptococcal species through which the pneumococcus has an extended gene pool to fuel genetic heterogeneity. Andrea is also interested in viral and bacterial co-infection.

Publications

Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger GE, Cobbold M, Buckley CD, Mitchell TJ, Mitchell A, Jones ND, Van Rooijen N, Kirchhofer D, Henderson IR, Adams DH, Watson SP and Cunningham AF (2015) Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest 125(12):4429-46

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC and Opitz B (2015) Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue. PLoS One 10(8):e0137108

Herbert JA, Mitchell AM and Mitchell TJ (2015) A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro. PLoS One 10(6):e0127212

Ross EA, Flores-Langarica A, Bobat S, Coughlan RE, Marshall JL, Hitchcock JR, Cook CN, Carvalho-Gaspar MM, Mitchell AM, Clarke M, Garcia P, Cobbold M, Mitchell TJ, Henderson IR, Jones ND, Buckley CD and Cunningham AF (2014) Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function. Eur J Immunol 44(8):2318-30

Croucher NJ, Mitchell AM, Gould KA, Inverarity D, Barquist L, Feltwell T, Fookes MC, Harris SR, Dordel J, Salter SJ, Browall S, Zemlickova H, Parkhill J, Normark S, Henriques-Normark B, Hinds J, Mitchell TJ and Bentley SD (2013) Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet 9(10):e1003868

Muchnik L, Adawi A, Ohayon A, Dotan S, Malka I, Azriel S, Shagan M, Portnoi M, Kafka D, Nahmani H, Porgador A, Gershoni JM, Morrison DA, Mitchell A, Tal M, Ellis R, Dagan R and Nebenzahl YM (2013) NADH oxidase functions as an adhesin in Streptococcus pneumoniae and elicits a protective immune response in mice. PLoS One 8(4):e61128

Arnold MF, Haag AF, Capewell S, Boshoff HI, James EK, McDonald R, Mair I, Mitchell AM, Kerscher B, Mitchell TJ, Mergaert P, Barry CE 3rd, Scocchi M, Zanda M, Campopiano DJ and Ferguson GP (2013) Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein. J Bacteriol 195(2):389-98

Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK and Dockrell DH (2012) Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathog 8(7):e1002814