Stuarts research focuses on the development and clinical implementation of physics-based techniques for the treatment of cancer. These are mainly particle therapy, and boron neutron capture therapy, although Stuart also has interests ion other binary therapies and in conventional radiotherapy techniques. He has also been involved in work to use chemicals which can be analysed on the breath as markers of disease or treatment.
Laser induced particle beams and LIBRA
Stuart is a Co-Applicant and a work-package coordinator for the EPSRC basic technology grant looking at the use of high power lasers as potential sources of particles for radiotherapy. This LIBRA consortium involves a large number of UK Universities and research institutes (see the LIBRA project site for more details.) with the Birmingham contribution being mainly related to accurate dosimetry of the emerging proton beams.
Boron Neutron Capture Therapy
Stuart is also a lead member of the Birmingham project to develop boron neutron capture therapy as a viable clinical option for treatment of highly invasive tumours which are poorly treated by conventional methods. Work on this project is currently following three main themes:
•Development of the University Dynamitron accelerator as a clinical treatment facility, with all necessary associated dosimetry
•Fundamental studies on the radiobiology of high and low LET radiations and the interaction between the damage which they produce
•Understanding and optimisation of the delivery of the novel boron carrier compound, BPA-Mannitol, to patients with certain kinds of brain tumour
Roels, H., Konings, J., Green, S., Bradley, D.,Chettle, D., and Lauwerys, R. (1995) Time integrated blood-lead concentrations is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement. Environmental Research 69 75-82.
Edwards CR, Green S, Palethorpe JE, Mountford PJ. (1997) The response of a MOSFET, p-type semiconductor and LiF T:D to quasi-monoenergetoc x-rays. Physics in Medicine and Biology 42, 2383-2391.
Farajollahi A R, Bonnett DE, Tattam D, Green S. (2000) The potential use of polymer gel dosimetry in boron neutron capture therapy, Physics in Medicine and Biology, 45, N9-14.
Wojnecki C and Green S (2002). A preliminary comparative study of two treatment planning systems developed for Boron neutron capture Therapy: MacNCTPlan and SERA. Medical Physics 29, 8, 1710-1715
Culbertson CN, Green S , Mason AJ, Picton D, Baugh G, Hugtenburg RP, Yin Z, Scott MC, Nelson JM (2004) In-phantom Characterisation Studies at the Birmingham Accelerator-Generated epIthermal Neutron Source (BAGINS) BNCT Facility. Applied Radiation and Isotopes, 61, (2004) 733-738
Pappas E, Maris TG, Zacharopoulou F, Papadakis A, Manolopoulos S, Green S, and Wojnecki C. (2008) Small SRS photon field profile dosimetry performed using a PinPoint air ion chamber, a diamond detector, a novel silicon-diode array (DOSI), and polymer gel dosimetry. Analysis and intercomparison. Medical Physics 35, Issue 10, pp. 4640-4648
O'Hara ME, O'Hehir S, Green S and Mayhew CM (2008) Development of a protocol to measure volatile organic compounds in human breath: a comparison of rebreathing and on-line single exhalations using proton transfer reaction mass spectrometry Physiological Measurement. 29, 309-330
Kirby D, Green S, Palmans H, Hugtenburg RP, Wojnecki C and Parker DJ, (2010) LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry, Physics in Medicine and Biology. 55, 417
Fiorini F, Kirby D, Green S and Parker DJ, (2010) Nuclear activation as a current detector for ion beams, Radiation Measurements 45, Issue 10, 1103-1104