Dr Sarah Aldred BSc (hons), MSc, PhD.

Dr Sarah Aldred

School of Sport, Exercise and Rehabilitation Sciences
Senior Lecturer in Exercise Biochemistry

Contact details

Telephone
+44 (0)121 414 7284
Fax
+44 (0)121 414 4121
Email
s.aldred.1@bham.ac.uk
Twitter
drsaldred
Address
School of Sport, Exercise and Rehabilitation Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Sarah Aldred is an exercise biochemist interested in oxidative stress. She is interested in how exercise can perturb redox homeostasis in both health and disease. Sarah has worked with young and old, and with those suffering from cardiovascular disease, metabolic syndrome, rheumatoid arthritis and dementia.

Qualifications

BSc (hons) Chemistry with Analytical Chemistry (University of Hull)
MSc Toxicology (University of Birmingham)
PhD Biochemistry (University of Birmingham)

Biography

Sarah joined the School of Sport, Exercise and Rehabilitation Sciences in October 2003 in order to develop her research interests in oxidative stress within a thriving Sport Sciences department. Originally from Yorkshire, Sarah studied at the Universities of Hull and Birmingham, before undertaking postdoctoral research at Aston University.Sarah's main research focusses on assessing how exercise and nutrition can perturb oxidative stress, inflammation and vascular function in health and disease. Sarah works in diseases associated with the ageing process, such as Alzheimer's disease, vascular dementia and cardiovascular disease. Sarah also has active research interests in exercise for maintenance of health and also investigates oxidative stress and inflammation in the context of exercise performance.

Sarah's research group comprises postgraduate research students and final year dissertation students and Sarah is herself still actively involved in lab research.

Teaching

Sarah is module organiser of the third year module ‘Oxidative stress in Exercise, Ageing and disease' and the first year module Biochemistry and cell physiology, and contributes to a number of other modules on the BSc Sport and Exercise Sciences, MSc Exercise and Sport Sciences, and the BMedSci courses.

Teaching awards:

Invited speaker at the 5th Annual Learning and Teaching conference, University of Birmingham, “Innovative methods of teaching; developing laboratory based modules” Feb 2008

Head of school award for excellence in learning and teaching, Awarded for innovation in teaching and teaching management –(the first award of its kind), 2007

Postgraduate associate certificate in Learning and Teaching, Aston University, 2002

Teaching management and administration:

Head of Education. School of Sport, Exercise and Rehabilitation Sciences (2011-2015)

Postgraduate supervision

Sarah has supervised many PhD students to completion. She also supervises Msc and Mres students in their research projects.

Publications directly associated with completed PhD projects:

Aldred S, and Rohalu, M. (2011). A moderate intensity exercise program did not increase the oxidative stress in older adults. Arch. Gerontol. Geriatr. Jan 12. [Epub ahead of print]

Aldred S., Rohalu, M.S., Edwards, K.M., and Burns, V.E. (2009) Altered DHEA and DHEAS response to exercise in healthy older adults. JAPA. 17(1):77-88.

Aldred S, Bennett S, Mecocci P. (2010) Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clinical Biochemistry. Feb;43(3):267-71. Epub 2009 Sep 4.

Bennett, S., Grant, M.M., and Aldred, S. (2009) Oxidative stress in Vascular dementia & Alzheimer’s disease; a common pathology. JAD. 17. 245-257.

Bennett, S., Grant, M.M., and Aldred, S. (2009) Oxidative stress in Vascular dementia & Alzheimer’s disease; a common pathology. JAD. 17. 245-257.

Bennett S, Grant M, Creese AJ, Mangialasche F, Cecchetti R, Cooper HJ, Mecocci P, Aldred S. (2011) Plasma Levels of Complement 4a Protein are Increased in Alzheimer's Disease. Alzheimer Dis Assoc Disord. Nov 2. [Epub ahead of print]

Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA. (2013) Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age (Dordr). Jul 12. [Epub ahead of print]

Turner JE, Bosch JA, Drayson MT, Aldred S. (2011). Assessment of oxidative stress in lymphocytes with exercise. J Appl Physiol. 2011 Jul;111(1):206-11. Epub 2011 Apr 14.

Turner JE, Bosch JA, Aldred S. (2011). Measurement of exercise-induced oxidative stress in lymphocytes. Biochem Soc Trans. Oct;39(5):1299-304.

Turner, J.E, Hodges, N.J, Bosch, J.A, and Aldred, S. (2011). Prolonged depletion of antioxidant capacity following ultra-endurance exercise. MSSE. 43 (9) 1770-1776.

Turner JE, Aldred S, Witard O, Drayson MT, Moss PM, Bosch JA. (2010). Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain Behav Immun. 24(8) 1362-1370.

Wadley AJ, Chen YW, Lip GY, Fisher JP, Aldred S. (2015) Low volume-high intensity interval exercise elicits antioxidant and anti-inflammatory effects in humans. J Sports Sci. 2015 Apr 27:1-9. [Epub ahead of print]

Wadley AJ, Chen YW, Bennett SJ, Lip GY, Turner JE, Fisher JP, Aldred S. (2015) Monitoring changes in thioredoxin and over-oxidised peroxiredoxin in response to exercise in humans. Free Radic Res. 2015 Mar;49(3):290-8. doi: 10.3109/10715762.2014.1000890. Epub 2015 Feb 4.

Wadley AJ, Veldhuijzen van Zanten JJ, Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, Kitas GD, Aldred S. (2014) Three months of moderate-intensity exercise reduced plasma 3-nitrotyrosine in rheumatoid arthritis patients. Eur J Appl Physiol. 114(7):1483-92. doi: 10.1007/s00421-014-2877-y. Epub 2014 Apr 10.

Wadley AJ, Veldhuijzen van Zanten JJ, Paine NJ, Drayson MT, Aldred S. (2014) Underlying inflammation has no impact on the oxidative stress response to acute mental stress. Brain Behav Immun. Aug;40:182-90. doi: 10.1016/j.bbi.2014.03.009. Epub 2014 Mar 24.

Research

Sarah's profile on Memory and Learning Group website

Oxidative stress is central to maintaining health, and arises when oxidants (produced by metabolic

processes) overwhelm antioxidants (produced by the body as a defence). The balance between oxidants and antioxidants forms part of a larger reduction-oxidation status within the cell, often referred to as redox balance.

Redox balance mediates cell function via processes such as cell signalling, gene expression, and cell proliferation. Redox disturbance and more specifically, oxidative stress has been directly linked to many diseases and disorders such as  cardiovascular disease, arthritis, metabolic syndrome disorders, cognitive decline, and neurodegenerative pathology including dementia.

Alongside Oxidative stress, many of these diseases or disorders are also associated with chronic inflammation and vascular dysfunction. Oxidative stress, inflammation and vascular function are intrinsically linked, however the interactions between these factors are not well understood.

Exercise can perturb oxidative stress, and thus may rebalance the redox disturbances that are seen in disease. Exercise is also anti-inflammatory in some situations, and can improve vascular function.

Dr Aldred’s laboratory investigates the mechanisms by which exercise can reduce oxidative stress, inflammation and vascular dysfunction, to improve health.

Current and future research projects in Dr Aldred’s lab include:

  • Investigating the effects of antioxidant supplementation on antioxidant enzyme expression, exercise performance and markers of inflammation
  • Investigating the effects of exercise intensity and duration on redox homeostasis, and vascular function in older age adults
  • Investigating the effects of increased exercise volume on oxidative stress and inflammation in older adults receiving care
  • Investigating the mechanisms by which caloric restriction may improve metabolic health
  • Investigating the effects of varying exercise intensity and duration for metabolic health

Other activities

Sarah is a member of a number of professional bodies to support her research including: The Biochemical Society; The American College of Sports Medicine, The Society of Toxicology, and European College of Sports Science. Sarah is also a member of the Alzheimer’s Society and has given a number of talks at the Alzheimer’s society Quality Research in Dementia public meetings, and the Alzheimer’s Research Trust public awareness events. Sarah has also presented her work at the British Science Festival.

Sarah is a founding member of the Alzheimer’s Research UK Midlands Network of researchers. 

Sarah is an active citizen of the University. She has held several administrative positions within the School, College and University during her appointment.

Publications

Brown, J.E., Mosley, M.  and Aldred, S. (2013) Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascular disease? BJDVD. 13 (2) 68-72.

Paine, N.J., Ring, C., Aldred, S., Bosch, J.A., Wadley, A.J. and Veldhuijzen van Zanten, J.J.C.S. (2013) Eccentric-exercise induced inflammation attenuates the vascular responses to mental stress. BBI. 30. 133-142.

Turner, J.E., Bennett S.J., Bosch, J.A., Aldred, S and Griffiths, H.R. (2013) The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes 7 days after ultra-endurance exercise. Free radical research. Free Radic Res. 2013 Oct;47(10):821-8. doi: 10.3109/10715762.2013.828836. Epub 2013 Aug 19.

Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA. (2013) Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age (Dordr). Jul 12. [Epub ahead of print]

Hartwich, D., Aldred, S., Fisher, JP. (2012) Influence of menstrual cycle phase on muscle metaboreflex control of cardiac baroreflex sensitivity, heart rate and blood pressure in humans. Experimental physiology. [Epub ahead of print].

Wadley AJ, Veldhuijzen van Zanten JJ, Aldred S. (2012). The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad. Age (Dordr). Mar 28. [Epub ahead of print]

Turner JE, Bosch JA, Drayson MT, Aldred S. (2011). Assessment of oxidative stress in lymphocytes with exercise. J Appl Physiol. 2011 Jul;111(1):206-11. Epub 2011 Apr 14.

Aldred S, Rohalu M. (2011). A moderate intensity exercise program did not increase the oxidative stress in older adults. Arch Gerontol Geriatr. Nov-Dec;53(3):350-3. Epub 2011 Jan 13.

Bennett S, Grant M, Creese AJ, Mangialasche F, Cecchetti R, Cooper HJ, Mecocci P, Aldred S. (2011) Plasma Levels of Complement 4a Protein are Increased in Alzheimer's Disease. Alzheimer Dis Assoc Disord. Nov 2. [Epub ahead of print]

Turner JE, Bosch JA, Aldred S. (2011). Measurement of exercise-induced oxidative stress in lymphocytes. Biochem Soc Trans. Oct;39(5):1299-304.

Turner, J.E, Hodges, N.J, Bosch, J.A, and Aldred, S. (2011). Prolonged depletion of antioxidant capacity following ultra-endurance exercise. MSSE. 43 (9) 1770-1776.

Turner JE, Aldred S, Witard O, Drayson MT, Moss PM, Bosch JA. (2010). Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain Behav Immun. 24(8) 1362-1370.

Aldred S, Bennett S, Mecocci P. (2010) Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clinical Biochemistry. Feb;43(3):267-71. Epub 2009 Sep 4.

Sarah Aldred and Patrizia Mecocci. (2010) Decreased dehydroepiandrosterone and dehydroepiandrosterone sulfate concentrations in plasma of Alzheimer’s disease patients. Arch Gerontol Geriatr. Jul-Aug;51(1):e16-8. Epub 2009 Aug 8

Ballard, C, Aarsland D, Aldred S, Bath P, Birks J, Brayne C, Kivipelto M, Richards M, Starr J, Smith D, and Kalaria R. (2010) Summary of the BBC dementia panel discussion. Alzheimers Society publications. Jan 2010.

Aldred S., Love,J.A., Tonks,L.A., Stephens,E., Jones, D.S., and Blannin,A.K. (2010)The effect of steady state exercise on circulating human IgE and IgG in young healthy volunteers with known allergy. JSAMS.  Jan;13(1):16-9. Epub 2008 Oct 31.

Aldred S., Rohalu, M.S., Edwards, K.M., and Burns, V.E. (2009) Altered DHEA and DHEAS response to exercise in healthy older adults. JAPA. 17(1):77-88.

Bennett, S., Grant, M.M., and Aldred, S. (2009) Oxidative stress in Vascular dementia & Alzheimer’s disease; a common pathology. JAD. 17. 245-257.

S.McPhee, Hans Degen, Keith Baar, Joaquin Perez Schindler, Sarah Aldred, Alun G. Williams, and David A. Jones. (2009). The training stimulus experienced by the leg muscles during cycling in humans. Exp Physiol. 94(6):684-94

Aldred S.Oxidative and nitrative changes seen in lipoproteins following exercise (2007). Atherosclerosis. May.192(1):1-8.

Griffiths HR, Aldred S, Dale C, Nakano E, Kitas GD, Grant MG, Nugent D, Taiwo FA, Li L, Powers HJ. Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake. Free Radic Biol Med. (2006) Feb 1;40(3):488-500.

Aldred S, Sozzi T, Mudway I, Grant MM, Neubert H, Kelly FJ, Griffiths HR. Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects. Proteomics. (2006) Mar;6(5):1695-703.

Aldred S. Travellers tales; Providing grants to attend scientific meetings. The Biochemist (2006) Feb; 28 (1) 60

Nakano E, Taiwo FA, Nugent D, Griffiths HR, Aldred S, Paisi M, Kwok M, Bhatt P, Hill MH, Moat S, Powers HJ. Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system. J Lipid Res. (2005) Mar;46(3):484-93.

Aldred S, Grant MM, Griffiths HR. The use of proteomics for the assessment of clinical samples in research. Clin Biochem. 2004 Nov;37(11):943-52. (Most cited paper in clinical biochemistry in 2004).

Aldred, S., & Griffiths, HR. Oxidation of human low density lipoprotein; Investigation of antioxidant protection in vitro. Environmental Pharmacology and Toxicology. (2004)  15:2-3, 111-117

Polidori MC, Mattioli P, Aldred S, Cecchetti R, Stahl W, Griffiths H, Senin U, Sies H, Mecocci P. Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord. 2004;18(3-4):265-70.

Jeukendrup AE, Aldred S. Fat supplementation, health, and endurance performance. Nutrition. 2004 Jul-Aug;20(7-8):678-88.

Aldred S, Moore KM, Fitzgerald M, Waring RH. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord. 2003 Feb;33(1):93-7.

Barralet JE, Aldred S, Wright AJ, Coombes AG. In vitro behavior of albumin-loaded carbonate hydroxyapatite gel. J Biomed Mater Res. 2002 Jun 5;60(3):360-7.

Aldred S, Foster JJ, Lock EA, Waring RH. Investigation of the localization of dehydroepiandrosterone sulphotransferase in adult rat kidney. Nephron. 2000 Oct;86(2):176-82.

Aldred S, Waring RH. Localisation of dehydroepiandrosterone sulphotransferase in adult rat brain. Brain Res Bull. 1999 Feb;48(3):291-6.

Conference abstracts:

Bennett, S and Aldred, S. 2008. Increased Low density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer’s Disease. Biochemical Society Transactions. Vol 36, part 5. P005

Aldred, Sarah; Matthews, Kathryn; Doubleday, Sarah; Jones, Rebecca S.; Gilson, Carina M.; Underwood, Thomas; Rohalu, Manjit Singh. 2006. The Effects of Exercise on DHEA, DHEAS and LDL Protein Carbonyl Concentrations in Healthy Adults. Medicine & Science in Sports & Exercise. 38(5) Supplement:S417,

Aldred S, Sozzi T, Mudway I, Grant MM, Neubert H, Kelly FJ, Griffiths HR. 2005. Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjectsSource: FREE RADICAL RESEARCH    Volume: 39    Pages: S90-S90    Supplement: Suppl. 1   

Rohalu, MS; Aldred, S.  2005 .The implications and effects of exercise intensity on the levels of dehydroepiandrosterone (DHEA) and its sulphated form (DHEA-S) FREE RADICAL RESEARCH   Volume: 39   Pages: S75-S75   

Mecocci P, Mattioli P, Cecchetti R, Griffiths H, Aldred S, Stahl W, Polidori MC. 2004. Protein oxidation, lipid peroxidation and antioxidant status are similarly altered in Alzheimer disease and vascular dementia. NEUROBIOLOGY OF AGING    Volume: 25    Pages: S542-S542    Supplement: Suppl. 2  

Aldred, S; Griffiths, HR. 2003. The use of proteomic analysis to assess oxidative insult, and protection by dehydroepiandrosterone, using cell model systems. TOXICOLOGICAL SCIENCES   Volume: 72   Pages: 80-80   Meeting Abstract: 385

Aldred S., Banks M., Kitas GD., Griffiths HR. (2002). Increased levels of oxidised LDL in the plasma of rheumatoid patients with cardiovascular disease: consequences for monocyte scavenger receptor uptake of LDL