Dr Jos Bosch PhD

Dr Jos Bosch

School of Sport, Exercise and Rehabilitation Sciences
Lecturer in Exercise and Behavioural Immunology

Contact details

+44 (0)121 414 8105
+44 (0)121 414 4121
School of Sport and Exercise Sciences
University of Birmingham
B15 2TT

Dr Jos Bosch is a biopsychologist with an expertise in Health Psychology, Psychophysiology and Psychoneuroimmunology; a field that studies the interactions between psychological, neuro-endocrine and immunological processes. His work involves both experimental research and epidemiological studies in healthy and clinical populations. Dr Jos Bosch is also associate editor of Health Psychology


Dr. Jos Bosch was born in Spain and raised in the Netherlands. Following an MA in Clinical Psychology and Biological Psychology at the University of Amsterdam (1991-1996), he completed his PhD in Biochemistry (with highest honours) at the Free University in Amsterdam in 2001. He was then a post-doctoral fellow associated with The Center for Stress and Wound Healing at The Ohio State University, USA, and became assistant professor at The University of Illinois at Chicago in 2003. In 2004 he was appointed as lecturer in the School of Sport and Exercise Sciences at the University of Birmingham.

Dr Jos Bosch currently also holds adjunct positions as associate professor at the University of Houston (Department of Health and Human Performance, TX, USA) and at the University of Heidelberg (Mannheim Institute of Public Health and Preventive Medicine, Germany).


  • Exercise and Behavioural Immunology (course leader)
  • Health Psychology

Postgraduate supervision

Jerrald Rector MSc (2010 – 2013) Psychosocial determinants of immunological ageing. Funding: Marie Curie fp7

Benjamin Curzon-Jones (2010 – 2013) The relationship between anxiety and increased falls risk in older adults (Primary supervisor Dr Mark Hollands). Funding: New Dynamics of Ageing.

Winnie Chan, MSc (2010 – 2013) Inflammation and fatigue in kidney transplant patients (co-supervision with Dr Richard Borrows). Funding: NHS West-Midlands.

Andrew McClean, MSc MD (2009 – 2012) Why are patients with ANCA-associated vasculitis fatigued: cardiovascular impairment, peripheral muscle dysfunction, or central involvement? (co-supervion with Prof. Lorraine Harper). Funding: NHS Arthritis Research Council.

Brian O’Hartaigh, MPhil (2009 – 2012) Psychosocial and behavioural determinants of immunesenescence (co-supervision with Dr Neil Thomas). Funding: BBSRC.

Agirta Zalli, BSc (2008 – 2011) Stress, catecholamines, and Cytomegalovirus reactivation (co-supervision with prof Paul Moss). Funding: MRC & SPORTEX.

Former lab members:

James E Turner, MSc (2007 – 2011) Exhaustive exercise as a determinant of oxidative stress and immunosenescence (currently post-doctoral fellow in Clinical Immunology, University of Birmingham).

Natalie E Riddell, BSc (2006 – 2010) Adrenergic regulation of T cell function (currently post-doctoral fellow in Experimental Immunology, University College London).

Leila H Anane, MSc (2005 – 2009) Stress lymphocytosis: mechanisms and clinical relevance (currently teaching staff).


  • Psychobiology and psychoneuroimmunology of stress and depression
  • Psychobiological and immunological mechanisms in ageing
  • Psychobiological and immunological mechanisms in chronic diseases and disease-related fatigue.

Other activities

Associate editor Health Psychology.


Bartelomew, K.J., Ntoumanis, N., Deci, E.L., Bosch, J.A., Thøgersen-Ntouman, C. (2011). Self-Determination Theory and Diminished Functioning: The Role of Interpersonal Control and Psychological Need Thwarting. Personality and Social Psychology Bulletin

Quested, E.J., Bosch J.A., Burns, V.E., Cumming, J., Ntoumanis, N., Duda, J.L. (2011). Basic Psychological Need Satisfaction, Cognitive Appraisals, and Dancers’ Hormonal and Emotional Responses. Journal of Sport and Exercise Psychology, In press

Mommersteeg, P.M., Hohe, R., Fischer, J.E., Bosch, J.A., Loerbroks, A. (2011). Longitudinal and cross-sectional associations between Type D personality and the metabolic syndrome. Journal of Psychosomatic Research, In press

Turner, J.E., Bosch, J.A., Aldred, S. (2011). Assessment of oxidative stress in lymphocytes during stress and exercise. Biochemical Society Transactions, In press

Loerbroks, A., Stock, A., Bosch, J.A., Litaker, D.G., Apfelbacher, C.J. (2011). Determinant s of influenza vaccination coverage among high-risk groups in eleven European countries: results from the Survey of Health, Ageing and Retirement in Europe (SHARE). European Journal of Public health, in press

Turner, J.E., Bosch, J.A., Hodges, N.J., Aldred, S. (2011) Prolonged depletion of antioxidant capacity following ultra-endurance exercise. Medicine and Science in Sport and Exercise, in press

Turner, J.E., Bosch, J.A., Drayson, M. T., Aldred, S. (In press) Assessment of oxidative stress in lymphocytes following exercise. Journal of Applied Physiology, In press

ó Hartaigh, B., Jiang, C.Q., Zhang, W.S., Bosch, J.A., Thomas, G.N., Lam, T.H., Cheng, K.K. (2011) Usefulness of seated resting heart rate and the metabolic syndrome in predicting vascular risk in older Chinese (From the Guangzhou Biobank Cohort Study – Cardiovascular disease sub-cohort [GBCS-CVD]). American Journal of Cardiology, In press

Bosch J.A., Veerman, E.C.I., Proctor, G.B. (2011). Salivary α-amylase as a measure of sympathetic activity: don’t start salivating just yet! Psychoneuroendocrinology, 36(4):449-53

Edwards, K.M., Tomfohr, L.M., Bosch, J.A., Mills, P.J., Ancoli-Israel, S., Loredo, J.S., Dimsdale, J.E. (2011). Macrophage Migratory Inhibitory Factor (MIF) may be a key factor in Inflammation in Obstructive Sleep Apnea. Sleep, 1;34(2):161-3

ó Hartaigh, B., Zhang, W.S., Bosch, J.A., Cheng, K.K., Jiang, C.Q., Lam, T.H., Thomas, G.N. (2011) Independent and combined associations of abdominal obesity and seated resting heart rate with type 2 diabetes among older Chinese: The Guangzhou Biobank Cohort Study. Diabetes and Metabolism Research and Reviews, 27(3):298-306

Redwine, L.S., Wirtz, P.H., Bosch, J.A., Hong, S., Linke, S., Ziegler, M.G., Greenberg, B., Mills, P.J. (2010). Depression as a potential modulator of β-adrenergic associated leukocyte mobilization in heart failure patients. Journal of the American College of Cardiologists, 16;56(21):1720-7

Turner, J.E., Aldred, S.A., Witard, O., Drayson, M.T., Moss, P.M., Bosch, J.A. (2010). Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain, Behavior & Immunity, 24(8):1362-70

Edwards, K.M., Bosch, J.A., Engeland, C.G., Cacioppo, J.T., Marucha, P.T. (2010). Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with increased depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol. Brain, Behavior & Immunity, 24(7):1202-8

Loerbroks, A., Apfelbacher, C.J., Bosch, J.A., Stürmer, T. (2010). Work-related stress, inability to relax after work and risk of adult asthma: a population-based cohort study. Allergy, 65(10):1298-305

Edwards K.M., Campbell, J.P., Ring, C., Drayson, M.T., Bosch, J.A., Paine, N.J., Burns, V.E. (2010). Exercise intensity does not influence the efficacy of eccentric exercise as a behavioural adjuvant to vaccination. Brain, Behavior & Immunity, 24(4):623-30

Anane, L.E., Burns, V.E., Edwards, K.E., Drayson, M.T., Bosch, J.A. (2010). Phenotypic analysis of γδ T cells mobilized in response to acute psychological stress. Brain, Behavior & Immunity, 24(4):608-14

Loerbroks, A., Apfelbacher, C.J., Bosch, J.A., Stürmer, T. (2010). Depressive symptoms and social support as risk factors for of adult asthma: findings from a population-based cohort study. Psychosomatic Medicine, 72(3):309-15

Campbell, J.C., Edwards, K.E., Drayson M.T., Bosch, J.A., Burns, V.E. (2010). The effects of vaccine timing on the efficacy of an acute eccentric exercise intervention on the immune response to an influenza vaccine in young adults. Brain, Behavior & Immunity, 24(2):236-42

Bosch, J.A., de Geus, E.J., Carroll, D., Anane, L.E., Helmerhorst, E.J., Goedhart, A.D., Edwards, K.E. (2009). A general enhancement of autonomic and cortisol responses during social evaluative threat. Psychosomatic Medicine, 71: 877-885

Anane, L.E., Burns, V.E., Veldhuizen van Zanten, J.J., Riddell, N.E., Drayson M.T., Mills, P.J., Bosch, J.A. (2009). Mobilization of γδ T cells in response to psychological stress, exercise and β-agonist infusion. Brain, Behavior & Immunity Aug;23(6):823-9

Riddell, N.E., Wallace, G.R., Van Stijn, A., van Lier,R.A., Drayson, M.T., Salmon, M., Bosch, J.A. (2009). Selective β-adrenergic receptor expression on human memory CD8+ T lymphocyte subsets regulates mobilization and INF-y production. Inflammation Research, 58: 255-260

Campbell, J.C., Burns, V.E., Riddell, N.E., Drayson M.T., Bosch, J.A. (2009). Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype. Brain, Behavior & Immunity, Aug;23(6):767-75

Bosch, J.A., Fischer, J.E., Fischer, J.F. (2009). Psychologically adverse working conditions are associated with CD8 T cell differentiation indicative of immunosenescence. Brain, Behavior & Immunity, May;23(4):527-34

Helmerhorst, E.J., Sun, X., Bosch J.A., Salih, E., Oppenheim, F.G. (2009). Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. Arch Oral Biol, 283(29):957-66

Bosch, J.A., Engeland, G.G., Cacioppo, J.T., Marucha, P.T. (2007). Depressive symptoms predict mucosal wound healing. Psychosomatic Medicine, 69(7) 597-605

Edwards, K.M., Burns V. E., Bosch, J.A., Carroll, D., Drayson M. & Ring, C.M. (2007). Eccentric exercise as an adjuvant to influenza vaccination in humans. Brain, Behavior & Immunity, 21(2):209-17

Engeland, G.G., Bosch, J.A., Cacioppo, J.T., Marucha, P.T. (2006). Mucosal wound healing; the role of age and gender. Ann Surg, 141(12):1193-7 (editorial on page 1198)

Phillips, A.C., Carroll, D., Evans, P., Bosch, J.A., Clow, A., Hucklebridge, F. & Der, G. (2006). Stressful life events are associated with low secretion rates of immunoglobulin A in saliva in the middle aged and elderly. Brain, Behavior & Immunity, 20(2): 191-197.

Rosenkranz, M.A., Busse, W.W., Johnstone, T., Crisafi, G.M., Bosch, J.A., Sheridan, J.F., Davidson, R.J. (2005). Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. Proc Natl Acad Sci USA, 102(37):13319-24

Bosch, J.A., Berntson, G.G., Cacioppo, J.T., & Marucha, P.T. (2005). Differential mobilization of functionally distinct Natural Killer subsets during acute psychological stress. Psychosomatic Medicine, 67: 366-375.

Nyklicek, I., Bosch, J.A., Nieuw Amerongen, A. V. (2005). Hypertensives exhibit a generalized physiological hyperreactivity to psychological stressors. Biological Psychology, 70(1):44-51

Bosch, J.A., de Geus, E.J.C., Ring, C., Nieuw Amerongen, A.V. (2004). Academic examinations and immunity: academic stress or examination stress? Psychosomatic Medicine, 53:213-214

Teeuw, W., Bosch, J.A., Veerman, E.C.I., Amerongen, A.V. (2004). Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health. Biological Chemistry, 385:1137-1146.

Bosch, J.A., de Geus, E.J.C., Veerman, E.C.I., Hoogstraten, J., Nieuw Amerongen, A.V. (2003). Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity. Psychosomatic Medicine, 65:245-258

Bosch, J.A., Berntson, G.G., Cacioppo, J.T., Dhabhar, F.S., & Marucha, P.T. (2003). Acute stress evokes selective redistribution of T lymphocytes that differ in chemokine receptor expression: A possible pathway linking reactivity with cardiovascular disease. Brain, Behavior & Immunity, 17:251-259

Bosch, J.A., Turkenburg, M., Nazmi, K., Ligtenberg, A.J.M., de Geus, E.J.C., Veerman, E.C.I., & Nieuw Amerongen, A.V. (2003). Acute stress as a determinant of saliva-mediated adherence and coadherence of oral and non-oral microorganisms. Psychosomatic Medicine, 65:604-612

Bosch, J.A., Veerman, E.C.I., Turkenburg, M., Hartog, K., Bolscher, J.G.M., & Nieuw Amerongen, A.V. (2003). A rapid fluorimetric assay for determining bacterial adherence using DNA-binding stains. Journal of Microbiological Methods, 53:51-56

Bosch, J.A., Ring, C., de Geus, E.J.C., Veerman, E.C.I., Nieuw Amerongen, A.V. (2002). Stress and secretory immunity. International Review of Neurobiology, 52:213-254

De Soet, J.J., Gruythuysen, R.J.M., Bosch J.A., Van Amerongen, W.E. (2002). The effect of 6-monthly application of 40% chlorhexidine varnish on the microflora and dental caries incidence in a population of children in Surinam. Caries Research, 36:449-455

Bosch, J.A., de Geus, E.J.C., Kelder, A., Veerman, E.C.I., Hoogstraten, J., Nieuw Amerongen, A.V. (2001). Differential effects of active versus passive coping on secretory immunity, Psychophysiology, 38:836-846

Bosch, J.A., de Geus, E.J.C., Ligtenberg, A.J.M., Nazmi, K., Veerman, E.C.I., Hoogstraten, J., Nieuw Amerongen, A.V. (2000). Salivary MUC5B-mediated adherence of Helicobacter pylori during acute psychological stress. Psychosomatic Medicine, 62:40-49

Bosch, J.A., Brand, H.S., Ligtenberg, A.J.M., Hoogstraten, J., Nieuw Amerongen, A.V. (1998). The response of salivary protein levels and S-IgA to an academic examination are associated with daily stress. J Psychophysiology, 12: 384-391

Bosch, J.A., Brand, H.S., Ligtenberg, A.J.M., Bermond, B., Hoogstraten, J., Nieuw Amerongen, A.V. (1998). Psychological stress as a determinant of protein levels and salivary-induced aggregation of Streptococcus gordonii in human whole saliva. Psychosomatic Medicine, 58:374-382


J.A. Bosch, A.C. Phillips & J.M. Lord (Editors). Immunosenescence: Psychosocial and Behavioral Determinants (In preparation, planned publication date June 2011). Springer, New York

Book chapters

Bosch, J.A., Riddel, N.E., ‘oHartaigh, B.O., Moss, P.A. (2011). Stress, cytomegalovirus infection and immunological aging. In: J.A. Bosch, A.C. Phillips & J.M. Lord (Eds.). Immunosenescence: Psychosocial and Behavioral Determinants. Springer, New York, In press

Burns V.E., Anane, L.H., Bosch, J.A. (2011). Stress and Immunity. In: M. Gellman & J.R. Turner (Eds). Encyclopedia of Behavioral Medicine. Springer, New York, In press

Bosch, J.A. (2011). Immune function. In: M. Gellman & J.R. Turner (Eds). Encyclopedia of Behavioral Medicine. Springer, New York, In press

Bosch, J.A. (2011). The immune system. In: M. Gellman & J.R. Turner (Eds). Encyclopedia of Behavioral Medicine. Springer, New York, In press

Bosch, J.A., Engeland, C.M., Burns V.E. (2010). Assessment of immune function in vivo: methods and principles. In: J. Decety & J.T. Cacioppo (Eds). Handbook of Social Neuroscience. Oxford University Press, New York, pp 213 – 26

Bosch, J.A., Veerman, E.C.I. (2008). Neural regulation of the saliva glands during stress and exercise. In: L. Sreebny & A. Vissink (Eds). Dry mouth: A clinical guide. Blackwell-Munksgaard Publishers, New York, pp 213 – 26

Hawkley, L.C., Bosch, J.A., Engeland, C.G., Marucha, P.T., & Cacioppo, J.T. (2007). Loneliness, dysphoria, stress and immunity: A role for cytokines. In: N. P. Plotnikoff, R. E. Faith, & A. J. Murgo (Eds.), Cytokines: Stress and immunity(2nd ed.). Boca Raton, LA: CRC Press.

Bosch, J.A. & Carroll D. (2006). Stress and mucosal secretory immunity. In: E. Fink (Ed.), Encyclopaedia of Stress (2nd ed.). London, United Kingdom: Elsevier.

Bosch, J.A. (2006). Stress and infectious diseases. In: A.A. Kaptein, R. Bunderman, J. Dekker, A.J.J.M. Vingerhoets (Eds.), Psychology and Medicine: behavioural medicine (3rd ed.)(in Dutch). Houten, Bohn, Stafleu van Loghum. p 193-217

Bosch, J.A. (2002). Stress and periodontal diseases. In: Brands H. & Ten Kate, M.P. (Eds.), Dental Year Book (in Dutch). Lisse, Swets and Zeitlinger


Stress and health; stress and infection; stress and the immune system; psychological stress and ageing; work stress and cardiovascular health