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Current research covers a wide portfolio of basic, translational and clinical research focusing on:

• Adrenal and gonadal steroids
• Thyroid cancer
• Thyroid dysfunction
• Fetal and reproductive endocrinology
• Pituitary disease
• Auto-immunity
• Genetics of diabetes and insulin resistance

Ongoing studies employ a broad range of in vitro and in vivo approaches including mouse transgenic and knockout models as well as clinical translational and interventional studies carried out in the Wellcome Trust Clinical Research Facility immediately adjacent to the Institute of Biomedical Research, the lab base for most of the Endocrine and Diabetes groups.

Clinical research is also enhanced by close interaction with the University Hospital and cohort and database studies (thyroid disease, pituitary disease, and adrenal disease).

Hormones and Genes research (Endocrinology, Diabetes and Metabolism and Genetics) represents a significant research strength within the College of Medical and Dental Sciences, as evidenced by the fact 75% of our RAE 2008 submission in the area of Other Hospital Based Clinical Subjects was considered internationally excellent or world leading.

Related links
School of Clinical and Experimental Medicine website: www.clinexpmed.bham.ac.uk  

• Endocrinology, Diabetes and Metabolism Group
  Head of Section:
  Professor Wiebke Arlt
• Pathogenesis, treatments and long term outcomes of thyroid dysfunction
  Contact: Professor Jayne Franklyn
  Email: j.a.franklyn@bham.ac.uk
• Pathogenesis of thyroid and other endocrine cancers
  Contact: Professor Christopher McCabe
  Email: c.j.mccabe@bham.ac.uk
• Pharmaceutical care; clinical pharmacy; medicines adherence; paediatric medicines use; novel paediatric formulations; pharmaceutical (and inter-professional) education 
  Contact: Professor John Marriott 
  Email: j.f.marriott@bham.ac.uk  
• Prereceptor regulation of glucocorticoid and mineralocorticoid action
  Contact: Professor Paul Stewart
  Email: p.m.stewart@bham.ac.uk 
• Prereceptor regulation of sex steroid action, mechanisms underlying androgen excess and deficiency
  Contact: Professor Wiebke Arlt
  Email: w.arlt@bham.ac.uk
• Bone metabolism, corticosteroids and inflammation
  Contact: Dr Mark Cooper
  Email: m.s.cooper@bham.ac.uk
• Mechanisms of Steroid Sulphation, Steroid Hormone trafficking and disorders of androgen excess
  Contact Dr Vivek Dhir
  Email: v.dhir@bham.ac.uk  
• Mechanisms underlying congenital adrenal hyperplasia, gonadal development
  Contact: Dr Nils Krone
  Email: n.p.krone@bham.ac.uk
• Glucocorticoids, insulin sensitivity and obesity
  Contact: Dr Jeremy Tomlinson
  Email: j.w.tomlinson@bham.ac.uk
• Diagnosis, treatment and prognosis in hypopituitarism, acromegaly an Cushing’s disease
  Contacts: Professor Paul Stewart
  Email: p.m.stewart@bham.ac.uk  
  Professor Wiebke Arlt
  Email: w.arlt@bham.ac.uk
• Clinical interventional studies for the treatment and prevention of type 2 diabetes; genetics of type 2 diabetes
  Contact: Professor Tony Barnett
  Email: anthony.barnett@heartsol.wmids.nhs.uk
• Mechanisms of insulin resistance in autoimmunity and type 1 diabetes
  Contact: Dr Parth Narendran
  Email: p.narendran@bham.ac.uk
• Microvascular diabetes complications – pathogenesis and treatment
  Contact: Professor Martin Stevens
  Email: m.j.stevens@bham.ac.uk

Respiratory Group
Our research focuses on investigating the factors governing neutrophil differentiation, activation and recruitment as processes that determine the degree of tissue damage resulting in the establishment and progression of chronic lung disease.

We have a major interest in chronic chest infections and the role of proteinases and proteinase inhibitors in this process, and are developing a regional and national programme for the screening, assessment and genetic counselling of patients with alpha-1-antitrypsin deficiency. This provides the basis for intervention studies to determine the role of alpha-1-antitrypsin replacement.

Contact:
Dr David Thickett
Email: d.thickett@bham.ac.uk
Professor Robert Stockley
Email: rob.stockley@uhb.nhs.uk

Clinical Pharmacology and Therapeutics Group

Hypoalgesia, sensory, motor and cognitive function in hypertension; blood pressure variability; adverse drug reactions and responses to antihypertensive medication
Contact: Dr Una Martin
Email: u.martin@bham.ac.uk  

Medication safety and adverse drug reactions; including pharmacoepidemiology, electronic prescribing/health informatics, and clinical decision suport methods
Contact: Dr Jamie Coleman
Email: j.j.coleman@bham.ac.uk