Recent advances in neuroscience demonstrate how the central nervous system (CNS) has a remarkable capacity to adapt and change over the course of one’s life or after injury. Activity-dependent neuroplasticity is the adaptation that occurs in the CNS as an individual learns new motor skills or relearns previously acquired movements. Principles of neuroplasticity, movement science, and learning provides a foundation for innovation in rehabilitation therapies. This course will examine the mechanisms of plasticity from the cellular to system level. The course will cover the basic science of neuroplasticity relevant to the normal CNS as it develops and ages; and the how it contributes to the recovery of function following injury to the nervous system. We will review mechanisms of plasticity from the synaptic level to the brain. We will examine how advances in neuroplasticity and neurorecovery have influenced rehabilitation. The format of this course will utilize formal lectures on current theories of neuroplasticity and class discussion on current literature in each of these areas. Case studies will be utilized to apply current theories to practical application.