Cellular Signalling

School of Biosciences

College of Life and Environmental Sciences

Details

Code 25351

Level of study Third/Final year

Credit value 20

Semester 2

Module description

This module aims to provide an integrated treatment of the biochemical / molecular basis of signalling processes downstream of diverse extracellular stimuli, emphasising those signalling pathways which are mediated by cell-surface receptors. Topics include receptor structure and function, G-protein-coupled receptors (GPCRs) and G-proteins, receptor tyrosine kinases and phosphatases, phospholipid signalling, Ca2+ signalling; nitric oxide signalling; nuclear receptor signalling; actions of second messengers; ligand-gated ion channel and electrical responses. The practical aims to provide an introduction to receptor binding techniques and the students will also be required to present data from an allocated primary research paper.

Teaching and learning methods

Lectures and practical classes plus directed reading of primary research papers and reviews.