Disruptions on the highways of cellular signalling
- Leonard Deacon Lecture Theatre, Medical School
- Medical and Dental Sciences
College of Medical and Dental Sciences - Named Lecture Series - Christie Gordon Lecture 2013
Professor Dario R Alessi, MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee
"Disruptions on the highways of cellular signalling"
My laboratory focuses on unravelling the roles of components that regulate protein phosphorylation or ubiquitylation pathways emerging from the genetic analysis of human disease. I will talk about how we have studied poorly characterised components of signal transduction pathways that are mutated in human disease such as LKB1 (Cancer), WNK1 (hypertension disorder) and Parkinson’s disease (PINK1 and LRRK2). I will present data that demonstrates how these pathways are organised, how they recognise signals, how the signal moves down the pathway to elicit physiological responses and to comprehend what goes wrong in human disease. I will also show examples of how our research findings enable us to play the engineer and devise new strategies to better treat and diagnose human disease.
This lecture is open to all, pre-registration is not required.