HEp-2: Cell Cycle Related Patterns In 'HEp-2 Image Library' ANA: NotesANA: +ve mitoticANA: -ve mitoticANA: NucleolarANA: Mixed patternHEp-2: Mitotics 1HEp2HEp-2: Cytoplasmic 1HEp-2: Cytoplasmic 2HEp-2: UncharacterisedS-phase unusual Back to 'Autoimmunity' Below are patterns seen in the S-phase of the HEp2 cells. These patterns resemble PCNA distribution (not typical PCNA) but with unknown clinical significance. Chromosome coating protein antibody This pattern has been referred to as PCNA variant and also "Chromosome coating protein antibody". It is related to the cell cycle. Unusual rim This is a cell cycle related nuclear rim (like anti-lamin) with a similar distribution to PCNA. Unusual peripheral rim This cell cycle related antibody stains the condensed chromosomal region (keyhole positive). The outer nuclear membrane is negative. Perhaps this is a variation of the pattern seen with peripheral rim. Atypical PCNA The granular speckled staining seen in the S-phase is unlike the PCNA. Cell cycle related cytoplasmic staining The Cytoplasmic staining seen in the S-phase.