HEp-2: Uncharacterised patterns In 'HEp-2 Image Library' ANA: NotesANA: +ve mitoticANA: -ve mitoticANA: NucleolarANA: Mixed patternHEp-2: Mitotics 1HEp2HEp-2: Cytoplasmic 1HEp-2: Cytoplasmic 2HEp-2: UncharacterisedS-phase unusual Back to 'Autoimmunity' Cytoplasmic dots This pattern appears to be similar to the glycine-tryptophan repeat bodies (GWB) antibody that is found in mitochondrial negative patients. The patient harbouring this antibody is a 39 year old male with a history of hepatitis C infection, who developed a cancerous lump and required liver transplant. This patient had raised polyclonal immunoglobulins and multiple dot ANA (liver associated) with a titre of 1/100 but LKM, smooth muscle and mitochondrial negative. Large dot in some nuclei Large dot in some nuclei (probably mitotic related). Rod-like fibres The appearance of this antibody is similar to cytoplasmic rings/rods pattern observed in some patients with HCV viral infection.