HEp-2: Uncharacterised patterns

Cytoplasmic dots


This pattern appears to be similar to the glycine-tryptophan repeat bodies (GWB) antibody that is found in mitochondrial negative patients. The patient harbouring this antibody is a 39 year old male with a history of hepatitis C infection, who developed a cancerous lump and required liver transplant.

This patient had raised polyclonal immunoglobulins and multiple dot ANA (liver associated) with a titre of 1/100  but LKM, smooth muscle and mitochondrial negative.

Large dot in some nuclei

Large dot in some nuclei (probably mitotic related).

Rod-like fibres

The appearance of this antibody is similar to cytoplasmic rings/rods pattern observed in some patients with HCV viral infection.