Antigen: Range of targets (e.g. myosin, actin): Antifibrillary antibody binding to the striations of primate cardiac muscle.
Disease: Antibody found in autoimmune myocarditis, cardiomyopathy and Dressler's syndrome
2004: A 37 year old male with previous history of chest pains. He was then treated for pericarditis.
2012: Admission reason for severe chest pain
Examination and work-up
• CT coronary angiography showed no evidence of coronary disease
• Echocardiography unremarkable
• Cardiovascular examination was normal
• ECG was within normal
• Trans-thoracic echocardiogram was normal
• Blood tests showed no increase in his inflammatory markers
• The initial assessment - recurrent pericarditis
• Pain was not typical of pericarditis
• Also complained of recurrent migraine
• Neurological review normal
• Head MRI - a few tiny high bi-frontal sub-cortical bright areas and scarring (not new)
• ANA, ANCA and double stranded DNA titres were all negative
• Cardiac striations were negative. No reaction with skeletal muscle
• Intercalated disc antibody present (see arrow heads)
Clinical indication: Intercalated disc antibody has been reported in association with autoimmunity idiopathic recurrent acute pericarditis.