Unusual antibodies

Unusual liver-kidney-stomach:

During autoantibody screening, there may be a possilibity of encountering a rare or unusual reaction of sera on the tissue which may be of no clinical significance. Here, we share some examples that you may be familiar with.

Liver: Bile Canaliculus antibodies

Rodent liver showing staining of the walls of the canaliculi. The clinical role of this antibody remains unclear

Kidney: Antibodies to tubule brush border

Brushborder membrane antibody staining the microvilli of the proximal kidney tubules. Microvilli are not present on the lumen of distal tubules hence most of the medulla is negative.


Higher magnification of the tubules. The clinical significance of this antibody in undetermined.

Epidermal screen:

A reaction of the serum autoantibodies against basal cell layer (see below).

Epithelial basal cell layer antibodies

Primate oesophagus epithelium: Basal cell layer antibodies. This antibody does not appear to have any clinical significance.