The final diagnosis is Acute myeloid leukaemia (AML) with myelodysplasia-related changes.
In the WHO classification there are three possible reasons for assigning cases to this subtype:
- AML arising from previous MDS or MDS/MPN
- AML with an MDS-related cytogenetic abnormality
- AML with multilineage dysplasia
To assign AML to this subtype, dysplasia must be present in at least 50% of the cells in at least two BM cell lines.
For this subtype, the patient should not have been exposed to prior cytotoxic therapy (this would be classified as therapy-related).