In restorative medicine, there is a growing need for biocompatible materials that can be controllably biodegraded into non-toxic materials while providing necessary biomechanics to support growth and healing of injured tissues (for example, bone cements). Conventional cements (e.g. PMMA) are photo cured for a few minutes which leads to increase of temperature at the place of curing up to 70oC and local tissue damage. Additionally, such cements are irritant, cannot be biodegraded or degrade releasing toxic products (e.g. bisphenol A). Some bone cements have led to bone cement implantation syndrome in patients who underwent hip transplants.
Researchers at the University of Birmingham have designed a novel biocompatible, biodegradable/resorbable two-component material that does not produce unwanted toxic products, can be rapidly cured using conventional light-curing units, and has excellent mechanical properties, suitable for hard tissue regeneration. The material has the added benefit of handleability and adaptability to the conformity of a defective site, in a clinical setup. The material is a mixture of two photocurable polymers P1 and P2 where contents of each can be varied depending on the application and desired mechanical properties. and that can be cost-effectively manufactured at industrial scales.
- Biodegradable resorbable material
- Does not produce toxic by-products
- Photocured by conventional equipment
- Excellent mechanical properties – suitable for hard tissue regeneration
- Easy handling and application
- Cost-effective manufacturing from readily available chemicals
- Range of components from biorenewable sources
- Restorative dentistry
- Surgical suture
- Tissue engineering
- Drug delivery
- Bone stabilisation
- Additive manufacturing
- Biomedical 3D‑printing.
- Partnership for development