Bioreaction Engineering

Module Title - Bioreaction Engineering
Number of credits – 10

Module description

This  module  deals  with  the  engineering  science  of  bioreactor  design;  of  the development of design tools which can be used to select and size equipment to carry out specific bioreaction tasks. This will involve lectures on:

  1. classification and configuration of bioreactors. 
  2. the basic kinetic models for biological growth which can be used in bioreaction modelling.
  3. combination of those equations with engineering models for bioreactors to create models for bioreaction systems.
  4. understanding non-ideal flow effects.
  5. understanding the effects of mixing and shear in bioreaction systems and how these can affect system behaviour.
  6. suitable instrumentation and control strategies.

By the end of the module you will be able to:

  • Understand enzyme nature and behaviour, and enzyme kinetics. 
  • Describe the types of bioreactors available, classify them and compare candidate designs. 
  • Understand and manipulate the equations which are used to  describe cell growth in bioreactors and the limitations of these equations.
  • Develop mathematical models for ideal bioreactor systems which can be used as the basis of design strategies.
  • Understand the limitations of bioreactor models, including the effects of non-ideal and their representation by RTD models, and how shear in bioreactor can damage productivity.
  • Describe the ways in which bioreactor control systems are constructed and used in both quantitative and simple mathematical approaches.

Teaching and assessment:

  • Semester 1.
  • Approximately 20 hours contact time.
  • 100% written exam (January). 
  • Reassessment: 100% exam (August).