Cell Factories

Module Title - Cell Factories
Number of credits – 20

Module description

This module defines and explains the principles of the large scale industrial production of a range of molecules, both pharmaceuticals and chemicals, by fermentation and cell culture.

The module comprises one week of lectures, tutorials and practical classes. Lectures will cover the basis for the choice of production system (bacterial, yeast, insect and mammalian cells) for the molecule of choice. Interactions between the organism and bioprocess environment, bioprocess monitoring and scale-up of bioprocesses will also be covered.

In the second week, students design and operate a pilot-scale bacterial fermentation process over the course of a week.

By the end of the module you will be able to:

  • Describe and compare the principles of animal, insect, bacterial, yeast and fungal cell culture.
  • Discuss the problems associated with the scale-up of such bioprocesses.
  • Present and criticise a current relevant research paper to an audience of peers.
  • Discuss the advantages/disadvantages of the wide range of analytical techniques used for monitoring bio-processes and apply such knowledge to the design and operation of bioreactors for specific industrial bioprocesses.
  • Plan and carryout laboratory and pilot scale fermentation processes and make process decisions based upon process measurements.

Teaching and assessment:

  • Semesters 1 and 2.
  • Approximately 67 hours contact time.
  • 100% coursework.
  • Reassessment: 100% coursework.