Birmingham Platelet Group

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Overview 

The Birmingham Platelet Group adopts a multidisciplinary approach in the investigation of platelet and megakaryocyte biology, which ranges from cell biology, signal transduction and functional studies through to the use of mouse models and studies on patients.

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Current Projects

  • Cell surface receptors and their signalling pathways, including ITAM and ITIM receptors, Src and Syk tyrosine kinases, and protein-tyrosine phosphatases
  • The genetics of platelet bleeding disorders
  • Megakaryocytopoiesis and platelet formation
  • Models of venous and arterial thrombosis
  • Animal models of cardiovascular diseases
  • Actin polymerisation and advanced microscopy
  • Platelet function testing
  • Granule biogenesis and secretion
  • Role of platelets in development and inflammatory processes
  • Extracellular vesicles
  • Platelet procoagulant activity

Selected Publications

Paul Harrison

  1. Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171
  2. Al Ghaithi R, Drake S, Watson SP, Morgan NV and Harrison P. Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders. J Thromb Haemost. 2017 Oct;15(10):2045-2052. doi: 10.1111/jth.13784. Epub 2017 Sep 13

Neil Morgan

  1. Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Sánchez Guiú I,Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP and Morgan NV  SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. J Clin Invest (2015), 125 (9), 3600-05.
  2. Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ and Komander D. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell (2016) 166, 1215-30.

Jun Mori

  1. Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijipers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A and Senis YA  Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.  Blood 2018, 131(10):1122-1144
  2. Senis YA, Mazharian A and Mori J.  Src family kinases: at the forefront of platelet activationBlood 2014, 124(13):2013-2

Natalie Poulter

  1. Montague SJ Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251.
  2. Poulter N.S, Pollitt A.Y, Owen D.M, Gardiner E.E, Andrews R.K, Shimizu H, Ishikawa D, Bihan D, Farndale R.W, Moroi M, Watson S.P and Jung S.M. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets (2017). Journal of Thrombosis and Haemostasis, 15(3):549-564.

Steve Watson

  1. Rayes J, Lax S, Wichaiyo S, Watson S, Di Y, Lombard S, Grygielska B, Smith S, Skordilis K and Watson SP. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.  (2017) Nature Commun. 8: 2239
  2. Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Depuis A, Babar AK, Miller JLC,  Philippou H, Hughes CE, Herr AB, Ariëns RAS, Mezzano D, Jandrot-Perrus M, Gachet C and Watson SP. Immobilized fibrinogen activates human platelets through GPVI. (2018) Haematologica in press

For full publications lists see:

Staff

Principal Investigators
Alexander Brill
Paul Harrison
Alexandra Mazharian
Neil Morgan
Jun Mori
Natalie Poulter
Yotis Senis
Mark Thomas
Steve Thomas
Steve Watson

Postdoctoral researchers
Amanda Dalby
Elisabeth Haining
Zoltan Nagy
Marie-Blanche Onselaer
Julie Rayes
Victoria Simms
Alexandre Slater
Timo Vogtle
Malou Zuidscherwoude

 PhD/MD Students
Pip Nicolson
Ibrahim Almazni
Fawaz Alenazy
Joanne Clark
Abdullah Khan
Annabel MacLachlan
Tom O'Sullivan
Chiara Pallini
Gina Perella
Chris Smith
Surasak Wichaiyo

Research Technicians
Mrs Ying Di
Mrs Lourdes Facia-Quintanilla
Dr Beata Grygielska 

Research Co-Ordinator
Mrs Gayle Halford

Close ties with other Principal Investigators on platelet related projects
Professor Roy Bicknell - Professor of Functional Genomics
Dr Andrew Blann - Non-clinical Senior Lecturer
Dr Neena Kalia - Senior Lecturer in Cardiovascular Sciences
Professor Gregory Y H Lip - Consultant Cardiologist & Prof of Cardiovascular Medicine
Dr Melanie Madhani - Senior Lecturer in Cardiovascular Medicine
Professor Gerard Nash - Professor of Cardiovascular Rheology
Professor Ed Rainger - Professor of Chronic Inflammation
Dr Michael Tomlinson - Senior Lecturer in the School of Biosciences
Dr Gillian Lowe - Consultant in Haemostasis and Thrombosis / Hon Senior Lecturer
Dr Mike Williams - Consultant Paediatric Haematologist/Honorary Lecturer