Periodontal Research Group
The Periodontal Research Group is active in identifying mechanisms underpinning the pathobiology of the inflammatory periodontal diseases at the cellular and molecular levels, by focussing upon novel pathways in the regulation of innate immune responses and how they become perturbed in response to infection.
Our research group
We are approaching this with three strands of research:
- We are embracing stratified medicine approaches to investigating the inter-relationships between periodontal inflammation and other chronic inflammatory diseases (such as chronic kidney disease, rheumatoid arthritis and COPD). This involves large longitudinal cohorts, phenotyped for periodontal status as well as medical status and the elucidation of the impact of periodontal interventions upon hard outcomes of the relevant medical co-morbidities.
- Biomarker discovery is also a major initiative, exploiting the accessibility and non-invasive collection of oral fluids like saliva and crevicular fluid. We utilise state-of-the art mass spectrometry techniques in association with the Advanced Mass Spectrometry Facility (http://www.birmingham.ac.uk/facilities/advanced-mass-spectrometry/index.aspx) to quantitatively assess oral fluids. Two US patents were filed in 2013/2014 (PCT/IB2013/058342 & PCT/IB2013/058431), testimony to our desire to impact positively upon patient care in primary care practice environments.
- Translation is a priority through clinical trials to provide novel diagnostics and host-modulating therapies. Indeed we have completed the first ever randomised phase 3 controlled trial of a phytonutrient supplement, designed for periodontitis treatment and developed over the last 6 years in collaboration with NSA LLC (Chapple et al. J Clin Perio 2012). The work is based upon our fundamental research into micronutrient approaches to modulating the redox environment of the cell as a novel approach to periodontal therapy and has recently moved into to a large European multicentre trial (ClinicalTrials.gov:NCT01229631). Fundamental research in collaboration with Dr Addison’s group and ENT is exploring potentially novel mechanisms through which transmucosal/dermal titanium osseointegrated implants may fail under the challenge of infection.
Ongoing research projects in this area:
Staff associated with this research include:
- Collaborations with other Schools/Hospitals:
- Renal Research Group (Queen Elizabeth Hospital)
- Rheumatology Research Group (Queen Elizabeth Hospital)
- Diabetes Research Group (Queen Elizabeth Hospital)
- Pulmonary Research Group (Queen Elizabeth Hospital)
- Barriatric Surgery Team (Heartlands Hospital)
- Centre for Ageing Research (Queen Elizabeth Hospital)
- ENT Research Group (Queen Elizabeth Hospital)