The Institute is uniquely placed in having a breadth of immunological interests spanning from fundamental science through translational immunology to the provision of a clinical immunology service to the NHS.
The aim of the Immune Regulation theme is to provide advances in fundamental understanding of the tissues, cells and molecules of the immune system. This knowledge is gained through analysis of immune cells from in vivo models.
We make extensive use of gene manipulation in in vivo models to define the role of specific molecules and apply cutting edge technologies to study them. Our aim is to determine the nature of lymphoid tissues and how their architecture contributes to immune cell differentiation and immune regulation; to define the nature of the genes, proteins and cells making up the innate and adaptive immune systems by characterising their role in differentiation, homeostasis and regulation of the immune response; to understand immunity to pathogens and how this can be used to improve vaccination strategies; and to define the pathogenesis of immunological diseases ranging from autoimmunity to transplant rejection and how to manipulate the immune system through immunotherapy.
Our strength lies in the breadth of interests represented by principal investigators in Immune Regulation and by their combined expertise in the use of gene manipulation in in vivo and experimental disease models to define the role of individual genes and proteins.
Our research strategy is to make fundamental discoveries that advance our understanding of the immune system and, where possible, build on these to design approaches for the prevention and treatment of human diseases.