CCB Seminar - Prof Louise Wain
- Centre for Computational Biology, Haworth building, Room 320
- Engineering and Physical Sciences, Lectures Talks and Workshops, Life and Environmental Sciences, Medical and Dental Sciences, Research
Jaspal Shambi - CCB Administrator
Prof Louise Wain
GSK/ British Lung Foundation Chair in Respiratory Research
University of Leicester
"Genetics of lung function and Chronic Obstructive Pulmonary Disease"
COPD, characterised by irreversible airflow obstruction and chronic airway inflammation, is the third leading cause of death globally. Smoking is the biggest risk factor but not all smokers develop COPD (~20% of COPD patients are never-smokers). There are no treatments that alter the course of disease, other than smoking cessation, and individuals with COPD have varying severity of symptoms and rates of progression.
Spirometrically-determined lung function measurements are key in the diagnosis and measure of severity of COPD. We hypothesised that the genetic determinants of lung function in large general population studies would be informative about susceptibility to COPD and provide a more statistically powerful alternative to COPD case-control studies of modest size. Using this approach 103 genetic signals of association with lung function have been reported to date. Collectively, our results show that individuals with a genetic risk score in the top decile are 3.7 times as likely to develop COPD compared to those in the bottom decile.
Understanding genetic factors associated with reduced lung function and COPD susceptibility could also inform drug target identification. A recent study showed that drug targets that have support from genetic studies are twice as likely to be successful in clinical development. Our GWAS findings have further strengthened evidence for targets already in development for treatment of COPD and other airway diseases, and identified potential new therapeutic avenues
The seminars are an opportunity for the CCB Community and external speakers to present their work or topics of interest to the bioinformatics community.
Wednesday 15 November 12.00 to 1.00 pm.
CCB Large Meeting & Teaching Room, Haworth Building.
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