Research

ResearchCurrent research focuses on these key areas:

Immune regulation in liver disease

  • The role of specific adhesion molecules and chemokines in the regulation of lymphocyte recruitment to the liver and gut.
  • The role of dendritic cells in regulating local immune responses in the liver.
  • Function of TNF receptor family members in controlling cellular activation and death.
  • Inflammation of the human liver and how this is linked to the development and progression of injury.

Hepatitis virology and immune evasion

  • Determinants of cell tropism for hepatitis viruses.
  • Immune evasion by hepatitis C and hepatitis B.

Primary liver cancer

  • Gene therapy and novel therapeutic interventions in hepatitis and non-hepatitis associated primary liver cancer.
  • Immune responses to hepatocellular carcinoma and cholangiocarcinoma and biomarkers for these cancers.

Tissue Injury and Transplantation

  • Immunity and cell-mediated injury in the liver.
  • Molecular regulation of ischemia reperfusion and pre-conditioning in the liver.
  • Regulation of inflammation in the liver.

Clinical Trials in Liver Disease

Our basic science research is being translated into early phase clinical trials through the NIHR Birmingham Biomedical Research Centre . We are also involved in a large number of pharmaceutical trials of new treatments for liver disease. Details of the trials can be found here and on our public involvement page.