A randomised controlled trial of different blood pressure targets for people with a history of stroke or transient ischaemic attack (TIA) in primary care

Blood pressure (BP) lowering in people who have had a stroke or transient ischaemic attack (TIA) leads to reduced risk of further stroke. However, it is not clear what the appropriate target BP should be, since intensification of therapy will lead to additional side-effects. The aim of PAST-BP is to determine whether more intensive targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life. We will recruit 610 patients from about 50 general practices and randomly assign them to a systolic BP target of 140 or 130mmHg (or a 10mmHg reduction, whichever is lower). The primary outcome will be change in systolic BP over twelve months. Secondary outcomes include quality of life, adverse events and clinical outcomes such as stroke and other vascular events.

Contact details:

Kate Fletcher
Programme Manager
Department of Primary Care & General Practice
Clinical Sciences Building
University of Birmingham
B15 2TT

Tel: +44 (0)121 414 8091
Fax: +44 (0)121 414 3759