Welcome to the BASIL-3 Trial Webpage

*** The BASIL-3 protocol paper has now been published in "Trials" and can be accessed from their website ***


Basil-3 is a multi-centre randomised controlled trial of clinical and cost-effectiveness of drug coated balloons, drug eluting stents, and plain balloon angioplasty with bail-out bare metal stent revascularisation strategies for severe limb ischaemia secondary to femoro-popliteal disease.


nihr_colourThe BASIL-3 Trial is funded by a NIHR Health Technology Assessment grant (project number 13/81/02).

Severe limb ischemia is the most serious and debilitating form of lower limb peripheral artery disease and is a seriously disabling, life and limb threatening, condition. The aim of BASIL-3 is to evaluate the clinical efficacy and cost-effectiveness of the interventions for people with severe limb ischaemia.

Trial Progress

Basil-3 officialy began its 3-year recruitment phase in February 2016, however due to receiving regulatory approval ahead of schedule, the lead centre (Heart of England NHS Foundation Trust) successfully entered the trial's first two participants during January of 2016. Since then, the trial has managed to meet or exceed each of its monthly targets, which are set by the National Institute for Health Research's HTA programme. This early success has firmly placed the cumulative recruitment total ahead of schedule.

As of 02 October 2017, a total of 33 clinical centres are open to recruit to the Basil-3 trial; 28 in England, 3 in Scotland, and 2 in Wales.  Thirty-two of the 33 clinical centres have cumulatively recruited 238 participants. We have 2 clinical centres which we anticipate will open to recruitment in the next 30 days. Tens of centres have formally expressed interest in opening Basil-3 and are at varying stages of start-up; we anticipate the majority of these opening within the next six months.


Basil-3 Trial Centres


Clinical centres currently open to recruit to Basil-3

 Centre name Local PI Opened

North Cumbria University Hospitals 

Mr Ron Eifell


Royal Cornwall Hospitals

Mr Harvey Chant


Heart of England NHS FT

Prof. Andrew Bradbury


Sheffield Teaching Hospitals

Dr Stephen Goode


Pennine Acute Hospitals

Dr Khalid Bashaeb


County Durham and Darlington

Mr Philip Davey


East Kent Hospitals

Dr Neelan Das


Colchester Hospital University

Dr Nagendra Thayur 


Dorset County Hospital

Mr James Metcalfe 


Imperial College Healthcare

Prof. Alun Davies 


Aneurin Bevan Health Board

Mr Christopher Twine 


United Lincolnshire Hospitals

Dr Geurino Centini 


Russell's Hall Hospital (Dudley)

Mr Simon Hobbs


Nottingham University Hospitals

Dr Said Habib


Basildon Hospital

Dr Jeremy Rabouhans


University Hospitals of North Midlands

Dr John Asquith


Freeman Hospital (Newcastle)

Prof. Gerard Stansby


Frimley Park Hospital

Mr Patrick Chong


Royal Infirmary of Edinburgh

Dr Graeme Weir


Leeds General Infirmary

Dr Jai Patel


Royal Wolverhampton Hospitals

Mr Simon Hobbs


Leicester Royal Infirmary

Mr Robert Davies


University Hospital of Wales

Dr Richard White


Dumfries and Galloway Royal Infirmary

Mr Joseph Sathianathan


Royal Sussex County Hospital

Mr Mario Caruana


Hull Royal Infirmary

Prof. Ian Chetter


St. Thomas' Hospital

Mr Hany Zayed


Southmead Hospital (Bristol)

Dr Alexander Horsch


Royal Bournemouth

Mr Lasantha Wijesinghe


University Hospital of South Manchester

Mr Ray Ashleigh


Manchester Royal Infirmary

Mr Tawqeer Rashid


Forth Valley Royal Hospital

Dr Nik Arestis


St. George's Hospital

Dr Raj Das



You can also see our clinical centres on the map.

The Basil-3 trial team are still accepting expressions of interest from UK-based vascular centres. NHS Trusts in England and Health Boards in the devolved nations should contact the Basil-3 trial office with the name of their proposed Principal Investigator to begin the start-up process for their site. We would typically expect a site Principal Investigator to be a Consultant Interventional Radiologist or a Consultant Vascular Surgeon with prior clinical research experience. Please see the contact us page for details of how to get in touch.

Current Basil-3 Recruitment (as of end of August 2017)

 Cummlative Recruitment Aug 17

For a more in depth overview of recruitment to Basil-3, visit our recruitment page.