RePHILL

RePHILL-LogoRePHILL (Resuscitation with Pre-Hospital Blood Products) is a multi-centre randomised controlled trial of pre-hospital blood product administration versus standard care for traumatic haemorrhage, funded by the National Institute for Health Research (NIHR) Efficacy & Mechanism Evaluation Programme (EME; project number 14/152/14). The trial will test the hypothesis that Pre-Hospital Blood Products (PHBP) resuscitation with up to two units each of packed red blood cells (PRBC) and lyophilised plasma (LyoPlas N-w) will improve tissue perfusion (as measured by lactate clearance) and reduce mortality in trauma patients with haemorrhagic shock compared to the current standard practice of crystalloid (normal saline) resuscitation.

RePHILL includes an internal pilot phase, where the trial will initially open in the West Midlands and in the East of England. The trial will then roll out to Essex & Hertfordshire and the East Midlands. The pilot phase will test logistical aspects of the trial and assess feasibility and recruitment. The first pilot sites opened to recruitment on December 5th 2016.

 

Design

A multi-centre randomised controlled trial of pre-hospital blood product administration versus standard care for traumatic haemorrhage.

Aim of Study

The principle objective of this trial is to investigate the clinical effectiveness of Pre-Hospital Blood Products (PHBP) resuscitation compared to the current standard care of restricted crystalloid based resuscitation in participants suffering from major traumatic haemorrhage.

Setting

 Pre Hospital Emergency Medicine (PHEM) and Major Trauma Centres (MTC)

Target Population

Patients believed to be over the age of 16 who have sustained a traumatic injury resulting in haemorrhage.

Intervention

Participants will be randomised between crystalloid resuscitation (up to four 250ml bags of 0.9% sodium chloride) or Pre-Hospital Blood Products resuscitation (up to two units of packed red blood cells and two units of LyoPlas).

The views expressed are those of the authors and not necessarily those of the NHS, NIHR or the Department of Health.

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