Study details

Full Title: Accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease: prospective longitudinal study in a multi-ethnic population.

Short Title: eGFR-C.

Aims of the study: To estimate and compare the accuracy and precision of GFR-estimating equations based on the MDRD equation and three CKD-EPI equations using either creatinine or cystatin C or a combination of both in people with stage 3 CKD.

Study design: Multi-centre UK prospective longitudinal cohort study.

Sample size: 1249 participants were recruited over 35 months.

Study Duration: The accrual period lasted 35 months and all patients in the main study will be followed up for 3 years. The end of trial will be 6 months after the last data capture. The total study duration is 83 months.

Timeframes: NIHR HTA grant start date: 1st August 2013. Study set up took place in 6 months, recruitment lasted 35 months, all main study patients will be followed up for 36 months and 6 months has been allocated for data analysis and report writing (final results due end of June 2020).


Further details...

Chief Investigator: Dr Edmund Lamb, East Kent Hospitals University NHS Foundation Trust

Study Co-Sponsors: East Kent Hospitals University NHS Foundation Trust and University of Birmingham (Ref: RG_13-176)

Funding: National Institute for Health Research Health Technology Assessment programme (HTA 11/103/01)

South East Coast - Surrey REC Reference No: 13/LO/1349


NIHR CRN Study ID: 15268