Selected recent publications

Here is a selection of our recent high impact publications. To view the full range from our expert scientists on their staff profiles visit the Principal Investigators page

Table showing recent high impact IMSR publications
 Authors Title Journal and date
 

Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW

 

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

 15 Nov 2019

 

Diabetologia.

doi: 10.1007/s00125-019-05029-y. [Epub ahead of print]

Fountas A, Lim ES, Drake WM, Powlson AS, Gurnell M, Martin NM, Seejore K, Murray RD, MacFarlane J, Ahluwalia R, Swords F, Ashraf M, Pal A, Chong Z, Freel M, Balafshan T, Purewal TS, Speak RG, Newell-Price J, Higham CE, Hussein Z, Baldeweg SE, Dales J, Reddy N, Levy MJ, Karavitaki N.

Outcomes of patients with Nelson's syndrome after primary treatment: a multicenter study from 13 UK Pituitary centers.

18 Nov 2019 

J Clin Endocrinol Metab

pii: dgz200. doi: 10.1210/clinem/dgz200. [Epub ahead of print]

Fletcher A, Read ML, Thornton CEM, Larner DP, Poole VL, Brookes K, Nieto HR, Alshahrani M, Thompson RJ, Lavery GG, Landa I, Fagin JA, Campbell MJ, Boelaert K, Turnell AS, Smith VE, McCabe CJ

Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.

31 Oct 2019

Cancer Res

pii: canres.1957.2019. doi: 10.1158/0008-5472.CAN-19-1957

Chortis V, Bancos I, Nijman T, Gilligan LC, Taylor AE, Ronchi CL, O'Reilly MW, Schreiner J, Asia M, Riester A, Perotti P, Libé R, Quinkler M, Canu L, Paiva I, Bugalho MJ, Kastelan D, Dennedy MC, Sherlock M, Ambroziak U, Vassiliadi D, Bertherat J, Beuschlein F, Fassnacht M, Deeks JJ, Biehl M, Arlt W

Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma.

29 Oct 2019

J Clin Endocrinol Metab

Epub ahead of print

Reisch N, Taylor AE, Nogueira EF, Asby DJ, Dhir V, Berry A, Krone N, Auchus RJ, Shackleton CHL, Hanley NA, Arlt W

 

Alternative pathway androgen biosynthesis and human fetal female virilization

29 Oct 2019

Proc Natl Acad Sci U S A. 

116(44):22294-22299. 

Edinburgh RM, Bradley HE, Abdullah NF, Robinson SL, Chrzanowski-Smith OJ, Walhin JP, Joanisse S, Manolopoulos KN, Philp A, Hengist A, Chabowski A, Brodsky FM, Koumanov F, Betts JA, Thompson D, Wallis GA, Gonzalez JT.

Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.

19 Oct 2019

J Clin Endocrinol Metab. 

pii: dgz104. doi: 10.1210/clinem/dgz104

Goranitis I, Lissauer DM, Coomarasamy A, Wilson A, Daniels J, Middleton L, Bishop J, Hewitt CA, Weeks AD, Mhango C, Mataya R, Ahmed I, Oladapo OT, Zamora J, Roberts TE

Antibiotic prophylaxis in the surgical management of miscarriage in low-income countries: a cost-effectiveness analysis of the AIMS trial.

 7 Sept 2019 

 

Lancet Glob Health

7(9):e1280-e1286. 

Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG.

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

13 Aug 2019

Cell Rep

28(7):1717-1728.e6. 

Fountas A, Lavrentaki A, Subramanian A, Toulis KA, Nirantharakumar K, Karavitaki N Recurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis

April 2019

J Clin Endocrinol Metab 

doi: 10.1210/jc.2018-01956

Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A.

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.

23 March 2019

N Engl J Med 14;380(11):1012-1021

doi: 10.1056/NEJMoa1808817

 

O'Reilly MW, Westgate CS, Hornby C, Botfield H, Taylor AE, Markey K, Mitchell JL, Scotton WJ, Mollan SP, Yiangou A, Jenkinson C, Gilligan LC, Sherlock M, Gibney J, Tomlinson JW, Lavery GG, Hodson DJ, Arlt W, Sinclair AJ.

 

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.

 21 March 2019

JCI Insight 4(6). pii: 125348

doi: 10.1172/jci.insight.125348

 

Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA.

 

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

 20 March 2018

Cell Rep. 22(12):3107-3114

doi: 10.1016/j.celrep.2018.02.084

Gorvin CM, Newey PJ, Rogers A, Stokes V, Neville MJ, Lines KE, Ntali G, Lees P, Morrison PJ, Singhellakis PN, Malandrinou FCKaravitaki N, Grossman AB, Karpe F, Thakker RV

Association of prolactin receptor (PRLR) variants with prolactinomas

15 March 2019

Human Mol Genet 

doi: 10.1093/hmg/ddy396

Lissauer D, Wilson A, Hewitt CA, Middleton L, Bishop JRB, Daniels J, Merriel A, Weeks A, Mhango C, Mataya R, Taulo F, Ngalawesa T, Chirwa A, Mphasa C, Tambala T, Chiudzu G, Mwalwanda C, Mboma A, Qureshi R, Ahmed I, Ismail H, Oladapo OT, Mbaruku G, Chibwana J, Watts G, Simon B, Ditai J, Otim Tom C, Acam J, Ekunait J, Unzia H, Iyaku M, Makiika JJ, Zamora J, Roberts T, Goranitis I, Bar-Zeev S, Desmond N, Arulkumaran S, Bhutta ZA, Gulmezoglu AM, Coomarasamy A

 

A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery.

 

 14 March 2019

N Engl J Med. 2019 14;380(11):1012-1021

doi: 10.1056/NEJMoa1808817