Selected recent publications

Here is a selection of our recent high impact publications. To view the full range from our expert scientists on their staff profiles visit the Principal Investigators page

Table showing recent high impact IMSR publications
 Authors Title Journal and date
Fountas A, Lavrentaki A, Subramanian A, Toulis KA, Nirantharakumar K, Karavitaki N Recurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis

April 2019

J Clin Endocrinol Metab 

doi: 10.1210/jc.2018-01956

Gorvin CM, Newey PJ, Rogers A, Stokes V, Neville MJ, Lines KE, Ntali G, Lees P, Morrison PJ, Singhellakis PN, Malandrinou FC, Karavitaki N, Grossman AB, Karpe F, Thakker RV

Association of prolactin receptor (PRLR) variants with prolactinomas

15 March 2019

Human Mol Genet 

doi: 10.1093/hmg/ddy396

Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A.

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.

23 March 2019

N Engl J Med 14;380(11):1012-1021

doi: 10.1056/NEJMoa1808817

 

O'Reilly MW, Westgate CS, Hornby C, Botfield H, Taylor AE, Markey K, Mitchell JL, Scotton WJ, Mollan SP, Yiangou A, Jenkinson C, Gilligan LC, Sherlock M, Gibney J, Tomlinson JW, Lavery GG, Hodson DJ, Arlt W, Sinclair AJ.

 

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.

 21 March 2019

JCI Insight 4(6). pii: 125348

doi: 10.1172/jci.insight.125348

 

Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA.

 

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

 20 March 2018

Cell Rep. 22(12):3107-3114

doi: 10.1016/j.celrep.2018.02.084

Lissauer D, Wilson A, Hewitt CA, Middleton L, Bishop JRB, Daniels J, Merriel A, Weeks A, Mhango C, Mataya R, Taulo F, Ngalawesa T, Chirwa A, Mphasa C, Tambala T, Chiudzu G, Mwalwanda C, Mboma A, Qureshi R, Ahmed I, Ismail H, Oladapo OT, Mbaruku G, Chibwana J, Watts G, Simon B, Ditai J, Otim Tom C, Acam J, Ekunait J, Unzia H, Iyaku M, Makiika JJ, Zamora J, Roberts T, Goranitis I, Bar-Zeev S, Desmond N, Arulkumaran S, Bhutta ZA, Gulmezoglu AM, Coomarasamy A

 

A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery.

 

 14 March 2019

N Engl J Med. 2019 14;380(11):1012-1021

doi: 10.1056/NEJMoa1808817

Lippert J, Appenzeller S, Liang R, Sbiera S, Kircher S, Altieri B, Nanda I, Weigand I, Gehrig A, Steinhauer S, Riemens R.J.M, Rosenwald A, Müller C.R, Kroiss M, Rost S, Fassnacht M, Ronchi C.L

Targeted Molecular Analysis in Adrenocortical Carcinomas: A Strategy Toward Improved Personalized Prognostication

1 December 2018

J Clin Endocrinol Metab 103(12):4511-4523

doi: 10.1210/jc.2018-01348

Mackie F.L, Hall M.J, Morris R.K, Kilby M.D Early prognostic factors of outcomes in monochorionic twin pregnancy: systematic review and meta-analysis

November 2018

Am J Obstet Gynecol. 219(5):436-446

doi: 10.1016/j.ajog.2018.05.008

Read M.L, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer

15 October 2018

Cancer Res;78(20):5863-5876.

doi: 10.1158/0008-5472.CAN-18-0855
Stoll V.M ,Drury N.E, Thorne S, Selman T, Clift P, Chong H, Thompson P.J, Morris R.K, Hudsmith L.E Pregnancy Outcomes in Women With Transposition of the Great Arteries After an Arterial Switch Operation

5 September 2018

JAMA Cardiol. 

doi:10.1001/jamacardio.2018.2747

Widmer, M, Piaggio, G, Nguyen, T.M.H, Osoti, A, Owa, O.O, Misra S, Coomarasamy A, Abdel-Aleem H, Mallapur A.A, Qureshi Z, Lumbiganon P, Patel A.B, Carroli G, Fawole B, Goudar S.S, Pujar Y.V, Neilson J, Hofmeyr, J.G, Su, L.L, de Carvalho J.F, Pandey U, Mugerwa K, Shiragur S.S, Byamugisha J,  Giordano, D, and Gülmezoglu A.M for the WHO CHAMPION Trial               

Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth 

23 August 2018

N Engl J Med 2018; 379:743-752

doi: 10.1056/NEJMoa1805489

Chortis V, Taylor A.E, Doig C.L, Walsh M.D, Meimaridou E, Jenkinson C, Rodriguez-Blanco G, Ronchi C.L, Jafri A, Metherell L.A, Hebenstreit D, Dunn W.BArlt WFoster P.A

Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma

 1 August 2018

Endocrinology; 159(8):2836-2849

doi: 10.1210/en.2018-00014.

Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. Neuronatin regulates pancreatic β cell insulin content and secretion

1 August 2018

J Clin Invest 128(8):3369-3381

doi: 10.1172/JCI120115

Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F.

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

21 June 2018

JCI Insight. 2018 Jun 21;3(12). pii: 98607

doi: 10.1172/jci.insight.98607

Hardy RS, Fenton C, Croft AP, Naylor AJ, Begum R, Desanti, Buckley CD. Lavery G, Cooper MS, Raza K 11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

8 June 2018

Journal of Autoimmunity, Volume 92, August 2018, Pages 104-113

doi.org/10.1016/j.jaut.2018.05.010

 

Gallos I.D, Williams H.M, Price M.J, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks J.J, Widmer M, Tunçalp Ö, Gülmezoglu A.M, Hofmeyr G.J and Coomarasamy A.

Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

25 April 2018

Cochrane Database Syst Rev.4:CD011689

doi: 10.1002/14651858

Kumarendran B, O’Reilly MW, Manolopoulos KN, Toulis KA, Gokhale KM, Sitch AJ, Wijeyaratne CN, Coomarasamy A, Arlt W, Nirantharakumar K   Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database

28 March 2018

PLOS Medicine

doi.org/10.1371/journal.pmed.1002542

Hollinshead K.E.R, Munford H, Eales K.L, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson D.J, Hua W, Tomlinson I.P, Ludwig C, Mao Y, Tennant D.A

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

20 March 2018

Cell Rep

doi: 10.1016/j.celrep.2018.02.084.

Plana M.N, Zamora J, Suresh G, Fernandez-Pineda L, Thangaratinam S, Ewer A.K

Pulse oximetry screening for critical congenital heart defects

1 March 2018

Cochrane Library

doi: 10.1002/14651858.CD011912.pub2

Gorvin CM, Babinsky VN, Malinauskas T, Nissen PH, Schou AJ, Hanyaloglu AC, Siebold C, Jones EY, Hannan FM and Thakker RV A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

20 February 2018

Science Signalling Vol. 11, Issue 518, eaan3714

doi: 10.1126/scisignal.aan3714

Elhassan Y.S, Idkowiak J, Smith K, Asia M, Gleeson H, Webster R, Arlt W, O’Reilly M.W 

Causes, Patterns, and Severity of Androgen Excess in 1205 Consecutively Recruited Women 

 12 January 2018

JCEM, Volume 103, Issue 3, March 2018, Pages 1214–1223

doi.org/10.1210/jc.2017-02426