Project completed in 2015.
Professor Michael Hannon, School of Chemistry
Dr Nik Hodges, School of Biosciences
Drs Tina Geraki / Burkhard Kaulich, Diamond Light Source
Dr Hamid Dehghani, School of Computer Science
To develop new fluorescent molecular probes and imaging techniques, including synchrotron imaging, in order to image metallo-cylinder uptake, localisation and trafficking in cancer cell lines in order to better understand activity.
To develop new molecular probes and techniques that will allow us to understand how the metallo-cylinder enters the cell, localises inside the cell and binds to DNA. These findings will then be compared to other metallo-based drugs and will provide a better understanding of the metallo cylinders action and give guidance in future synthetic designs in the metallo-drug field.