High resolution imaging and analysis of blood vessel formation and flow

Project completed in 2015.

Dr Victoria Heath, Institute of Cardivascular Sciences
Professor Roy Bicknell, Institute of Cardiovascular Sciences
Professor Zoe Pikramenou, School of Chemistry
Dr Iain Styles, School of Computer Science

This project aims to monitor, track, manipulate and analyse in detail the process of angiogenesis and to measure blood flow in vessels.  This process will be probed in a number of ways from using fluorescently tagged protein to nanoparticles coated with luminescent metal probes.  Images generated with these probes by time-lapse confocal microscopy and computational algorithms developed to calculate and model changes in vessel morphology and lumen size in developing vessels.