Multi-dimensional intravital imaging of signalling and trafficking during embryonic development

Project completed in 2015.

Professor John Heath, School of Biosciences
Dr Iain Styles, School of Computer Science
Professor Helen Cooper, School of Biosciences
Professor Ferenc Mueller, Institute of Cancer and Genomic Sciences

This project will develop and apply novel high-content imaging, data processing and analysis strategies to elucidate the interdependent nature of growth factor receptor signalling and trafficking.  In particular this project is focusing on computational approaches employing 2D and 3D "level-sets" algorithms to automatically extract quantitative localisation data from high-resolution live-cell imaging studies.