Supervisors and module leaders

Please not this is not as exhaustive list as we regularly embark on new collaborations on both mini-projects and PhDs.

We have over 60 academics from across the university involved in our multi-disciplinary program. Names of some of these members are shown here. Expand each entry to see keywords illustrative of their research at the life sciences interface; and details of projects they supervise. Only full PhD projects are listed here; many of these academics also supervise first year mini-projects. 

Physical Scientists

Professor Liam Grover

Materials science; Chemical engineering; Bioresponsives; Orthopaedic applications

Personal and group webpages

Projects:

  • “The development of biophysical characterisation of novel biomimetic cartilage models for the repair of joint cartilage in early osteoarthritis”
  • “Tracking and Evaluating the Influence of Wear Particles on Cellular Behaviour and Tissue Formation”
  • "Controlling collagen formation in wounds using smart dressings"
  • "Imaging the development of a bone to bone ligament construct"
  • "Imaging of root canal preparation"
  • "Development of multifunctional calcium phosphate particles for drug delivery and formation of cross-linked materials"
  • "Design & develop an injectable, light curable and resorbable material for intramedullary stabilisation of upper extremity fractures"

Dr Rob Neely

Chemistry; Fluorescence spectroscopy and microscopy

 Personal webpage

Projects:

  • "Expansion microscopy as a tool to investigate DNA repair"
  • “STORM in a Teacup: Quantification of Receptor-Surface Interactions in Single Cells Through the Application of Novel Recognition Techniques in Super Resolution Images”
  • “Single-molecule imaging of the myelin proteins”
  • “Single-molecule methods for visualizing protein-DNA interactions”
  • "Developing a high-resolution optical mapping setup with integrated high-throughput analysis capabilities for dissecting molecular mechanisms of cardiac arrhythmias"
  • "Novel computer image analysis and machine learning methods for quantitative characterisation of the drug/receptor interactions in metastatic breast cancer"

Dr Anita Ghag

Development of novel, functional materials which have the potential to be used in bone tissue engineering applications

Personal webpage

Dr Pola Goldberg-Oppenheimer

Chemical Engineering; Novel Lithographic Techniques, Structural Nanotechnology, Structured Carbon Nanotubes & Graphene-Based Devices

Personal webpage

Projects:

  • "Development of point of care technologies for traumatic brain injury diagnostics"
  • "Controlling collagen formation in wounds using smart dressings"

Dr  Francisco Fernandez-Trillo

Chemistry; Biomedical Applications of Nanotechnology 

Personal webpage

Professor Michael Hannon

Bioinorganic chemistry; supramolecular chemistry; metal-based drugs; DNA recognition; biological chemistry and chemical biology 

Projects:

  • "Multimodal nano-theranostic systems targeting tumour biomarkers"
  • "Development of novel fluorescent molecular probes and synchotron imaging techniques to study the uptake of metallo-cylinder drugs"
  •  "New fluorescent probes for nucleic acid quadruplex structures in cells"
  • "Development of novel imaging techniques to improve understanding and specificity of targeting and cellular uptake of super paramagnetic iron oxide nanoparticles(SPIONS)"
  • "Engineering of a specific binding site for protein labelling with luminescent lanthanide coated nanoparticles: A study of protein labelling and nanoparticles"
  • "Developing new molecular probes: Multimodal imaging agents for tracking cells"
  • "Investigations in MALDI-MSI using a high repetition rate laser"
  • "Determining the cellular localisation of novel cancer therapeutics"

Professor Zoe Pikramenou

Chemistry; New molecular and nano sized  markers and probes: Development of functional metal and silica nano particles with targeting vectors

Personal webpage

Projects:

  • "Optical Imaging of Vasculature in Tumours Using Novel Gold Nanoparticle Probes"
  • "Using silicon nanoparticles for the therapeutic imaging of tumour vessels"
  • "Multimodal nano-theranostic systems targeting tumour biomarkers"
  • "Luminescent Nanoparticles Coated with Targeting Vectors to Probe Cellular Delivery"
  • "Nanoparticle delivery of nucleic acid probes for SNP detection in the cell and sIRNA mediated gene inactivation"
  • "Imaging of platelet actin dynamics with high spatial and temporal resolution"
  • "Engineering of a specific binding site for protein labelling with luminescent lanthanide coated nanoparticles: A study of protein labelling and nanoparticles"
  • "Developing new molecular probes: Multimodal imaging agents for tracking cells"
  • "Multimodal Nanosized Agents Based on Nanoparticles Coated with Metal Probes to target Delivery in Cells"
  • "Advancing optical imaging of electrical activation and repolarisation of the heart using genetically altered models"
  • "High resolution imaging and analysis of blood vessel formation and flow"

Dr Anna Peacock

Bioinorganic chemistry and de novo peptide design. In particular, the development of novel metallopeptides with potential therapeutic applications. 

Personal and group webpages

Projects:

  • "Super Resolution Cellular Imaging of a New Class of MRI Contrast Agents"

Professor Helen Cooper

Development and application of mass spectrometry techniques for the characterisation of bio molecular and non-biomolecular structures 

Personal and group webpages

Projects:

  • "Biomolecular tetris: Elucidating the structural consequences of phosphorylation"
  • "Combining SRS and MS for High Resolution Quantitative Imaging of Drugs, Lipids and Proteins in Tissue: Powerful New Tools for Pharmaceutical Research"
  • "Unique Combination of MSI and SRS for Enhanced Informationand Imaging Metrology"
  • "Development of liquid extraction surface analysis mass spectrometry for the investigation of biomarkers and molecular mechanisms of renal fibrosis"
  • "Multi-dimensional intravital imaging of signalling and trafficking during embryonic development"

Professor Roy Johnston

Chemistry; simulation of solids, surfaces and clusters; modelling cluster growth and dynamics; nanoalloy clusters; electronic structures of inorganic and organic solids

Personal webpage

Professor Paula Mendes

Chemistry; nanoscience and nanotechnology; biomimetic materials for studies of cell behaviour; applications in medical imaging and catalysis 

Personal webpage

Projects:

  • "Development of diagnostic technology for differentiating sterile and non-sterile inflammation"

Professor Jon Preece

Supramolecular chemistry; nanoscale materials science for (i) electron beam resists; (ii) assembly of inorganic/ organic hybrid nanoparticles with novel electro-optic, structural and medicinal properties (gene delivery); (iii) liquid crystals; (iv) surfaces used in technological applications 

 

Professor Jim Tucker

Supramolecular chemistry; ferrocene chemistry; photochromic systems; hydrogen-bonding receptors 

Personal and group webpages

Projects:

  • "Nanoparticle delivery of nucleic acid probes for SNP detection in the cell and sIRNA mediated gene inactivation"
  • "Development of Fluorophore-tagged DNA probes for Cellular Imaging Applications"

Dr Jensen Li

Transformation Optics; Acoustic Metamaterials; Metamaterials and Plasmonics

Personal webpage

Projects:

  • “Superimaging with Metamaterials for Cardiovascular Disease”

Dr Alex Robinson

Development of new materials and techniques for nanofabrication, novel devices and nanopatterned surfaces 

Personal webpage

Dr Carl Anthony

Microsystems engineering, Micro-Sensor arrays, Energy Harvesting, Focused Ion Beam microfabrication techniques. 

Personal webpage

Dr Daniel Espino

Bio-medical Engineering, computational modelling and mechanical testing of connective tissues

Personal webpage

Dr Daniele Vigolo

Soft condensed matter and fluid dynamics; design and realisation of advanced biocompatible materials exploiting microfluidics.

Personal webpage

Projects:

  • “Experimental and computational investigation of the mechanisms of deep venous thrombosis”

 Computational Scientists

Professor Hamid Dehghani

Computer science; physiological measurements; optical imaging; image reconstruction; molecular imaging

Personal and group webpages

Projects:

  • "Diffuse optical tomography imaging in rheumatoid arthritis"
  • "Functional Near Infrared Spectroscopy (fNIRS) of the human brain to assess traumatic brain injury."
  • "Obstacle avoidance for surgical procedures using image-guided neurosurgical robot"
  • "Imaging of Light Emitting Biological Reporters in Murine Models Using Optical Molecular Imaging"
  • "Development of a Multispectral Diffuse Optical Tomography System for Earlier Diagnosis of Rheumatoid Arthritis (RA)"
  • "Strategies for adaptive radiotherapy: towards clinically efficient workflows"
  • "Fast parallel multivariate analysis of mass spectrometry imaging data: A new approach for studying human liver disease"
  • "Imaging the development of a bone to bone ligament construct"
  • "Development of novel fluorescent molecular probes and synchotron imaging techniques to study the uptake of metallo-cylinder drugs"
  • "Investigation of Brain Microenvironments Using Advanced Diffusion MRI"
  • "The development of a novel MRI based method for measuring blood perfusion in neurovascular damage"
  • "Tracking and Evaluating the Influence of Wear Particles on Cellular Behaviour and Tissue Formation"
  • "Probabilistic Framework for Optical Image Reconstruction"
  • "Using silicon nanoparticles for the therapeutic imaging of tumour vessels"
  • "Multi-modal diffuse optical tomography and bioluminescence tomography system for pre-clinical imaging"
  • "Liquid micro-junction surface sampling and MALDI imaging of small and large molecules in human liver disease"
  • "Developing new molecular probes: Multimodal imaging agents for tracking cells"
  • "Simultaneous electroencephalography and functional near-infrared spectroscopy for accurate diagnosis of prolonged disorders of consciousness"
  • "Developments in MR spectroscopic imaging acquisition and analysis"
  • "Multimodal nano-theranostic systems targeting tumour biomarkers"
  • "Optical Imaging of Vasculature in Tumours Using Novel Gold Nanoparticle Probes"
  • "Advancing optical imaging of electrical activation and repolarisation of the heart using genetically altered models"

Dr Iain Styles

Computer science; Image Analysis, Mass Spectrometry Imaging, and Intelligent data analysis & optimisation

Personal webpage

Projects:

  • "Unique Combination of MSI and SRS for Enhanced Information and Imaging Metrology"
  • "Fast parallel multivariate analysis of mass spectrometry imaging data: A new approach for studying human liver disease"
  • "Information processing for mass spectrometry imaging"
  • "Biomolecular tetris: Elucidating the structural consequences of phosphorylation"
  • "Development of point of care technologies for traumatic brain injury diagnostics"
  • "Developing a high-resolution optical mapping setup with integrated high-throughput analysis capabilities for dissecting molecular mechanisms of cardiac arrhythmias"
  • "Luminescent Nanoparticles Coated with Targeting Vectors to Probe Cellular Delivery"
  • "Developing Light Field Technology in Biomedical Imaging"
  • "STORM in a Teacup: Quantification of Receptor-Surface Interactions in Single Cells Through the Application of Novel Recognition Techniques in Super Resolution Images"
  • "Diffuse optical tomography imaging in rheumatoid arthritis"
  • "Nanoparticle delivery of nucleic acid probes for SNP detection in the cell and sIRNA mediated gene inactivation"
  • "Development of novel imaging techniques to improve understanding and specificity of targeting and cellular uptake of super paramagnetic iron oxide nanoparticles(SPIONS)"
  • "Expansion microscopy as a tool to investigate DNA repair"
  • "Controlling collagen formation in wounds using smart dressings"
  • "Combining SRS and MS for High Resolution Quantitative Imaging of Drugs, Lipids and Proteins in Tissue: Powerful New Tools for Pharmaceutical Research"
  • "Obstacle avoidance for surgical procedures using image-guided neurosurgical robot"
  • "Superimaging with Metamaterials for Cardiovascular Disease"
  • "Light Field Imaging"
  • "Development of liquid extraction surface analysis mass spectrometry for the investigation of biomarkers and molecular mechanisms of renal fibrosis"
  • "Probabilistic Framework for Optical Image Reconstruction"
  • "Articulated Statistical Atlas Construction for the Analysis of Bone Erosion in Models of Rheumatoid Arthritis"
  • "Multi-modal diffuse optical tomography and bioluminescence tomography system for pre-clinical imaging"
  • "Multi-dimensional intravital imaging of signalling and trafficking during embryonic development"
  • "Liquid micro-junction surface sampling and MALDI imaging of small and large molecules in human liver disease"
  • “The development of biophysical characterisation of novel biomimetic cartilage models for the repair of joint cartilage in early osteoarthritis”
  • “Single-molecule imaging of the myelin proteins”
  • “Single-molecule methods for visualizing protein-DNA interactions”
  • "Imaging intracellular infections by a fatal fungal pathogen"
  • "Novel approaches for assaying and imaging in vitro wound healing"
  • "Development of tools for imaging of macrophages and macrophage-resident pathogens"
  • "Design & develop an injectable, light curable and resorbable material for intramedullary stabilisation of upper extremity fractures"
  • "Super Resolution Cellular Imaging of a New Class of MRI Contrast Agents"
  • "Imaging of Light Emitting Biological Reporters in Murine Models Using Optical Molecular Imaging"
  • "Development of a Multispectral Diffuse Optical Tomography System for Earlier Diagnosis of Rheumatoid Arthritis (RA)"
  • "High resolution imaging and analysis of blood vessel formation and flow"

Professor Ales Leonardis

Computer Science; Computational vision 

Personal webpage

Projects:

  • “Obstacle avoidance for surgical procedures using image-guided neurosurgical robot”

Professor Ela Claridge

Computer science; multi spectral imaging, physics of image formation, quantitative fluorescence microscopy, biomedical image analysis, modelling

Personal webpage

Projects:

  • "Developing Multispectral Topographic Imaging as a Tool for Pre-clinical and Clinical Imaging of Rheumatoid Joints"
  • "Light Field Imaging"
  • "Imaging of platelet actin dynamics with high spatial and temporal resolution"
  • "Information processing for mass spectrometry imaging"
  • "Developing Light Field Technology in Biomedical Imaging"
  • "Novel computer image analysis and machine learning methods for quantitative characterisation of the drug/receptor interactions in metastatic breast cancer"
  • "Four dimensional analysis of vesicle dynamics during cell migration"
  • "Probabilistic Framework for Optical Image Reconstruction"
  • "Articulated Statistical Atlas Construction for the Analysis of Bone Erosion in Models of Rheumatoid Arthritis"
  • "Imaging of root canal preparation"
  • "Engineering of a specific binding site for protein labelling with luminescent lanthanide coated nanoparticles: A study of protein labelling and nanoparticles"
  • "Determining the cellular localisation of novel cancer therapeutics"

Dr Ata Kaban

Computer science; statistical machine learning; data mining; high dimensional data spaces; probabilistic modelling of data; Bayesian inference 

Personal webpage

Projects:

  • "Fast parallel multivariate analysis of mass spectrometry imaging data: A new approach for studying human liver disease"
  • "Liquid micro-junction surface sampling and MALDI imaging of small and large molecules in human liver disease"

Dr Peter Tino

Artificial intelligence; machine learning; neural networks; evolutionary computation; bioinformatics; computational biology; intelligent methods for pattern recognition; molecular biology, computational models of dynamical systems

Personal webpage

Projects:

  • "Development of diagnostic technology for differentiating sterile and non-sterile inflammation"
  • "Simultaneous electroencephalography and functional near-infrared spectroscopy for accurate diagnosis of prolonged disorders of consciousness"
  • "Imaging intracellular infections by a fatal fungal pathogen"
  • "Investigations in MALDI-MSI using a high repetition rate laser"

Biomedical Scientists

Dr Steve Thomas

Cardiorespiratory science; actin dynamics; megakaryocytes; visualising the dynamics of proteins in live platelets for study of the cytoskeleton; actin nodules

Personal webpage

Projects:

  • "Luminescent Nanoparticles Coated with Targeting Vectors to Probe Cellular Delivery"
  • "STORM in a Teacup: Quantification of Receptor-Surface Interactions in Single Cells Through the Application of Novel Recognition Techniques in Super Resolution Images"
  • "Expansion microscopy as a tool to investigate DNA repair"
  • "Superimaging with Metamaterials for Cardiovascular Disease”
  • "Imaging of platelet actin dynamics with high spatial and temporal resolution"
  • "Developing Light Field Technology in Biomedical Imaging"

Professor Janet Lord

Medicine; immune senescence, chronic inflammation, leukaemia

Personal webpage

Projects:

  • “Development of diagnostic technology for differentiating sterile and non-sterile inflammation”
  • “Tracking and Evaluating the Influence of Wear Particles on Cellular Behaviour and Tissue Formation”

Professor Ann Logan

Medicine; Neurodegeneration and repair of the damaged and diseased central nervous system

Personal webpage

Projects:

  • "Development of point of care technologies for traumatic brain injury diagnostics"

Professor Gerard Nash

Medicine; haemodynamics, vascular biology, blood rheology

Personal webpage

Projects:

  • “Experimental and computational investigation of the mechanisms of deep venous thrombosis”
  • "Development of Fluorophore-tagged DNA probes for Cellular Imaging Applications"

Professor Damien Walmsley 

Dentistry; ultrasonics, bio-effects; imaging of vibration characteristics; biological effects of low-frequency (kHz) ultrasonic instruments 

Personal webpage

Projects:

  • "Imaging of clinical ultrasonic biofilm removal via micro-CT and ultrasound techniques"
  • "Imaging of root canal preparation"

Professor Steve Watson

Cardiovascular sciences and cellular pharmacology; physiological and pathological features and roles of platelets in activation by glycoprotein receptors; actin polymerisation; angiogenesis; cancer metastasis; major organ dysfunction; stem cell recruitment

Personal and group webpages

Projects:

  • "Advancing optical imaging of electrical activation and repolarisation of the heart using genetically altered models"

Dr Nigel Davies

Child health; functional Imaging and metabolomics of childhood cancer; magnetic resonance spectroscopy metabolite profiles for characterising childhood tumours  

Projects:

  • "Imaging the functional brain: fusion of magnetic resonance spectroscopy and functional magnetic resonance imaging in a human learning (visual acuity) paradigm"

Professor Jon Frampton

Stem cell biology; processes causing failures of stem cell regulation 

Personal webpage

Professor Kevin Chipman

Mechanistic cellular and genetic toxicology, toxic genomics and nanotoxicology in relation to both human health and the health of organisms in the aquatic environment. 

Personal webpage

Dr Andrew Filer

Inflammation and inflammatory disease; predictive and therapeutic approaches to the treatment of inflammatory arthritis including roles of stromal fibroblast cells in regulating the switch to persistence 

Personal webpage

Projects:

  • "Diffuse optical tomography imaging in rheumatoid arthritis"
  • "Developing Multispectral Topographic Imaging as a Tool for Pre-clinical and Clinical Imaging of Rheumatoid Joints"
  • "Articulated Statistical Atlas Construction for the Analysis of Bone Erosion in Models of Rheumatoid Arthritis"
  • "Development of a Multispectral Diffuse Optical Tomography System for Earlier Diagnosis of Rheumatoid Arthritis (RA)"

Professor Paulus Kirchhof

Cardiovascular sciences; novel molecular mechanisms of heart disease; controlled clinical trials to translate pathophysiological insights into new therapies for heart disease; the evaluation and improvement of clinical management of patients with heart disease, especially cardiomyopathies, heart failure, and arrhythmias 

Personal webpage

Professor Gabriel Landini

Dentistry; applied fractal principles to study morphological complexity; image segmentation; quantitative measurement and focusing

Personal webpage

Projects:

  • "Novel approaches for assaying and imaging in vitro wound healing"

Professor Ferenc Mueller

Reproduction, genes and development; molecular mechanisms of transcription regulation in the vertebrate embryo; comparative and functional genomic tools to address the interaction specificity of transcription factors

Personal webpage

Projects:

  • "Developing Light Field Technology in Biomedical Imaging"
  • "Multi-dimensional intravital imaging of signalling and trafficking during embryonic development"

Dr Rachel Sammons

Surface interactions between mammalian cells and bacteria and biomaterials – especially titanium and hydroxyapatite, for bone repair and the prevention of infection

Personal webpage

Professor Owen Addison

Biomedical materials science with a particular interest in the behaviour of materials in physiological environments

Personal webpage

Dr Simon Wyn Jones

Inflammatory and metabolic mechanisms, skeletal muscle dysfunction and atrophy in chronic disease and understanding the functional role of non-coding RNAs in mediating inflammatory responses. 

Personal webpage

Projects:

  • “The development of biophysical characterisation of novel biomimetic cartilage models for the repair of joint cartilage in early osteoarthritis”

Professor Antonio Belli

Neurobiochemistry and neuromonitoring of acute brain injury, early markers of tissue damage for the prevention of secondary injury after trauma and subarachnoid haemorrhage, patient stratification and drug discovery. 

Personal webpage

Projects:

  • “Functional Near Infrared Spectroscopy (fNIRS) of the human brain to assess traumatic brain injury.”
  • "Development of point of care technologies for traumatic brain injury diagnostics"

Dr Ben Scheven

Dental pulp and bone cell biology, mesenchymal stem cells in tissue repair and regeneration, nerve repair and neuronal stem cell differentiation, therapeutic ultrasound and oral cancer.

Personal webpage

Professor David Adams

Tumour Immunology and Immune/Gene Therapy

Personal webpage

Dr Larissa Fabritz

Novel mechanisms of heart disease and performs translational research towards mechanism-based therapies of cardiovascular diseases. 

Personal webpage

Projects:

  • "Developing a high-resolution optical mapping setup with integrated high-throughput analysis capabilities for dissecting molecular mechanisms of cardiac arrhythmias"
  • "Advancing optical imaging of electrical activation and repolarisation of the heart using genetically altered models"

Dr Davor Pavlovic

Molecular mechanisms of ion transport in the heart; heart failure, arrhythmias and cardiorenal syndrome.

Personal webpage

Projects:

  • "Developing a high-resolution optical mapping setup with integrated high-throughput analysis capabilities for dissecting molecular mechanisms of cardiac arrhythmias"