Studies

StudiesCRN West Midlands continually seeks to engage with local GP practices and pharmacies in order to participate in a broad range of Portfolio studies. 

They cover a range of topics for which primary care has a particular responsibility. Involvement in our studies requires differing levels of engagement for example:

  • Direct patient recruitment during clinical consultations
  • Opportunistic patient recruitment
  • Electronic searches
  • Providing patients with study leaflets
  • Displaying study posters within the practice

Take part

If you are interested in taking part in any of the studies, please call us on +44 (0)800 085 4229 or email us.

Trials coming soon

Here we have provided information about NIHR portfolio studies that will be coming to the Birmingham and Black Country region soon.  If you would like to find out more, please follow the links.  You can also contact us and we will register your interest with the study team here in Birmingham.

 

Acronym and title

Portfolio ID Number

BOOST
Better Outcomes for Older People with Spinal Trouble (BOOST) Research Programme

TBC450

SAFA (Spironolactone for Adult Female Acne)
A pragmatic multicentre double-blind randomised superiority trial to investigate the clinical and cost-effectiveness of spironolactone for moderate or severe persistent acne in women

40693

Snacktivity
Snacktivity to promote physical activity and reduce future risk of disease in the population

Research Facilitator: Lucy Hughes
Email: lucy.hughes@nihr.ac.uk

 

Trials open to recruitment

Here we have provided information about NIHR portfolio studies that are currently open to recruitment within the Birmingham and Black Country area.  Please note that some studies may be specific to a particular Clinical Commissioning Group (CCG) or may not currently be recruiting new practices, so please email us if you require further information.

For more information on a study or to express an interest, please contact the Research Facilitator responsible for the study.

 

Acronym and title

Portfolio ID Number

AdipO2
Body fat distribution and diabetes risk: the role of adipose tissue oxygen metabolism

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

38728

AIM HY INFORM - ComparIsoN oF Optimal Hypertension RegiMens
AIM HY INFORM aims to determine if the response to antihypertensive drugs differs by self-defined ethnicity 

Research Facilitator: Lucy Hughes
Email: lucy.hughes@nihr.ac.uk

32856

ARRISA-UK
At-Risk Registers Integrated into primary care to Stop Asthma crises in the UK

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

18118

ARTIC PC
Antibiotics for lower Respiratory Tract Infection in Children presenting in Primary Care

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

31950

ATTACK
Aspirin To Target Arterial events in Chronic Kidney disease

Research Facilitator: Saif Uddin
Email: saif.uddin@nihr.ac.uk

37100

CHICO
The Children with Cough Cluster Randomised Controlled Trial (The CHICO RCT)

Research Facilitator: Anuradha Krishna
Email: anuradha.krishna@nihr.ac.uk

37163

CLASP5
Cancer: Life Affirming Survivorship support in Primary care Programme-Internal Pilot and Randomised Controlled Trial

Research Facilitator: Sheila Bailey
Email: sheila.bailey@nihr.ac.uk

37052

IPOPP
Increasing physical activity in older people with persistent musculoskeletal pain

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

39973

Med-EX UK (Mediterranean diet, exercise and dementia risk in UK adults)
A randomised controlled trial investigating the feasibility of a multi-domain intervention to increase Mediterranean Diet (MedDiet) Score and Physical Activity (PA) of older UK adults who are at above average risk of dementia

Research Facilitator: Sheila Bailey
Email: sheila.bailey@nihr.ac.uk

40181

NCMH
The National Centre for Mental Health (NCMH) is a Welsh Government funded Research Centre, operated by Cardiff University, Swansea University and Bangor University, in collaboration with NHS Health Boards across Wales and NHS Trusts in England. We obtain information about participants’ mental and physical health, lifestyle, and background, as well as biological samples, and link these to routine clinical NHS data. NCMH also provides opportunities for members of the cohort to learn about, and volunteer to participate in, other ethically approved high quality studies. 

Research Facilitator: Lucy Hughes
Email: lucy.hughes@nihr.ac.uk

34524

Partners 2 - Collaborative Care for People with Serious Mental Illness (Workstream 4)
Partners 2 is a trial of primary care based collaborative care for people with a diagnosis of schizophrenia, bipolar or other types of psychosis

Research Facilitator: Lucy Hughes
Email: lucy.hughes@nihr.ac.uk

36484

Q-PROMPPT (Qualitative study to design the PROMPPT intervention)
A multimethod qualitative study to inform design of a proactive clinical review of patients prescribed opioid medicines long-term for persistent pain, led by clinical pharmacists in primary care teams (PROMPPT intervention)

Research Facilitator: Sheila Bailey
Email: sheila.bailey@nihr.ac.uk

41817

REST - open to SystmOne practices ONLY
The Runny Ear STudy - immediate oral, immediate topical or delayed oral antibiotics for Acute Otitis Media with discharge

Research Facilitator: Marie Crook
Email: marie.crook@nihr.ac.uk

37299

Stakeholder perceptions of preventive approaches to rheumatoid arthritis
Qualitative study of healthcare professionals' perspectives on predictive and preventive strategies

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

43528

SupportBack 2
Supporting self-management of low back pain with an internet intervention in primary care

Research Facilitator: Alastair Mobley
Email: alastair.mobley@nihr.ac.uk

39195

Treat to Target in Gout
Three arm RCT to test whether a brief behavioural intervention increases average step count in patients with chronic musculoskeletal pain compared to usual Primary Care or receiving a pedometer and diary.

Research Facilitator: Beth Hinks
Email: elizabeth.hinks@nihr.ac.uk

42053

UCON
Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; includinguterine fibroids): a randomised controlled trial and exploration of mechanism of action

Research Facilitator: Anuradha Krishna
Email: anuradha.krishna@nihr.ac.uk

18534

Trials closed to recruitment

Where possible we try to feedback results of studies that our primary care practitioners and their patients have become involved in.  Further results will be added as and when they become available.

 

Acronym and title

Portfolio ID Number

3C - Cough Complication Cohort Study

 7647

ACCURATE
How accurate are home blood pressure monitors used by patients?

20163

AF-GEN-UK
Long-term Registry of Patients with Atrial Fibrillation UK Extension Study

33430

ALL-HEART
Allopurinol & cardiovascular outcome in Heart Disease

15328

ALPHA
Comparison of Alitretinoin with PUVA as the first line treatment in patients with severe chronic hand eczema (The ALPHA trial)

18012

ARCHIE
GPs’ views on antibiotic prescribing in at-risk children with influenza-like illness

 14253

ARCHIE
The early use of Antibiotics in 'at-Risk' CHildren with Influenza

 15212

ASPIRE
Aspirin Resistance Among Pregnant Women at Risk of Preeclampsia

 14468

AURAS-AF
Automated Risk Assessment for Stroke in Atrial Fibrillation (AURAS-AF)

 13972

BAFTA - Follow up
Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Follow-up

 14812

BARACK-D
Benefits of Aldosterone Receptor Antagonism in Chronic Kidney DIsease

14611

BrIT
Brains in Transition - Linear and non-linear brain changes over the transition to psychosis

15937

CANDID
CANCER DIagnosis Decision rules

13492

CAP
Case Note Review Study (CNRS) - Diagnosis and management of prostate disease in the UK

8830

CEDAR
Children's ear drops for ear pain in acute otitis media: The CEDAR Randomised Controlled Trial and Observational Cohort Study

30521

CHESS
Chronic Headache Education and Self-management Study 

 33285

COMPOD
Community-based Prevention of Diabetes trial

 17309

CONDUCT Study
The effectiveness and acceptability of urine collection devices to reduce contaminated urine samples in women presenting with symptoms of urinary tract infection - a 3 arm trial in UK Primary Care

 32443

CPRD DECIDE - Commercial Study
A Pragmatic Trial to Evaluate the Comparative Effectiveness Between Dapagliflozin and Standard of Care in Type 2 Diabetes Patients

 

CVR-AF
Cerebral vasomotor regulation in Atrial Fibrillation

20224

DAPA
Physical activity programmes for community dwelling people with mild to moderate dementia (DAPA Dementia And Physical Activity)

13164

Digital Access Now
To find out how patients are interacting with internet and online sources for accessing general practice services and information, and to analyse how this varies according to patient characteristics and health status.

40230

EAST
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

 12670

e-coacher
Web support for exercise referrals

16261

eGFR-C
Accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease: prospective longitudinal study in a multi-ethnic population.

 15268

EVRA
Early Venous Reflux Ablation Ulcer Trial

15078

ExACT
Extended Anticoagulation Treatment for VTE: a randomised trial

10144

EXVIT-D (Exercise and vitamin D supplementation in older adults)
Influence of combined vitamin D supplementation and resistance exercise training on musculoskeletal health in frail older men and women

34783

FAST Gout
Febuxostat versus Allopurinol Streamlined Trial

11338

FLU-CATS
Evaluation and refinement of pandemic influenza community assessment tools

12827

FOAM
A phase III randomised study of FOlic Acid supplementation in the management of Menopausal symptoms in cancer survivors and healthy postmenopausal women

18588

GARFIELD-AF 
Global Anticoagulant Registry in the FIELD

9879

GCA
The Impact of Giant Cell Arteritis (GCA) Study

18119

HA-1
HA-1 Heterologous Prime Boost Vaccine Study

13063

HEAT
Helicobacter Eradication Aspirin Trial

11921

ICARE-P
Partnership in Prostate Cancer

20614

Impress-AF
IMproved exercise tolerance in patients with PReserved Ejection fraction by Spironolactone on myocardial fibrosiS in Atrial Fibrillation

18080

I-WOTCH
The overall aim of the I-WOTCH study is to conduct a randomised controlled trial to test the effectiveness and cost effectiveness of a multicomponent self- management intervention targeting the withdrawal of strong opioids on activities of daily living in comparison to best usual care for people living with chronic non-malignant pain. 

 

OSAC
Oral Steroids for Acute Cough Trial

 13751

LASER
Laminar Airflow in Severe Asthma for Exacerbation Reduction
A multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly controlled, severe allergic asthma.
www.lasertrial.co.uk 

16394

Measuring General Practice Productivity

20099

MEDREV
Supporting Primary Care with Challenging Behaviour in Dementia

 30441

MIMMS
Summary of the Mixed Methods Multimorbidity Study (MiMMS)

30613

OPAL
Oxford Pain, Activity and Lifestyle Study

30343

OPTIMISE
OPtimising Treatment for Mild Systolic hypertension in the Elderly 

33014

PACE
Primary Care use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit

 17248

PANDA
RCT to investigate the severity and duration of depressive symptoms associated with a clinically important response to SSRI antidepressants in people with depression

 16264

PARTNERS2
Development and pilot trial of primary care based collaborative care for people with serious mental Illness - Workstream 1

16841

Patient Safety Toolkit

15053

PIMMS-WL
Feasibility and acceptability of a brief routine weight management intervention for post-natal women

36526

POPS2
Effectiveness of regular weighing and feedback by community midwives in preventing excessive gestational weight gain: randomised controlled trial

 17504

PPEC Study
An exploration of parents’ perceptions and experiences of using e-cigarettes in homes with children

204259

PreFIT
Prevention of Fall Injury Trial

 10617

PMR
An inception cohort of primary care patients diagnosed with polymyalgia rheumatica

 12752

Preloading
An open label pragmatic randomised controlled trial of nicotine patch preloading for smoking cessation

 11918

PROM for PMR
Study looking into the use of patient reported outcome measures (PROMs) as one tool to help in the drive to achieve the goal of person-centred care for patients with polymyalgia rheumatica (PMR)

37751

PRONIA
Personalised Prognostic Tools for Early Psychosis Management

16955

PROVE
Physiotherapy Rehabilitation for Osteoporotic Vertebral fracture

13141

PSM-COPD
Patient Self-Management in primary care patients with Chronic Obstructive  Pulmonary Disease

 14642

RATE-AF Study
RAte control Therapy Evaluation in Atrial Fibrillation - evaluating different rate control therapies in permanent atrial fibrillation: A prospective, randomised, open-label, blinded endpoint trial comparing digoxin and beta-blockers as initial rate control therapy

 32563

REACH-HF
Rehabilitation Enablement in Chronic Heart Failure

17779

REACT
The REACT (REtirement in ACTion) study: A randomised controlled trial and economic evaluation of a community­-based physical activity intervention to prevent mobility­related disability for retired older people: The REACT (REtirement in ACTion) trial

20578

REACTS
Return to Employment After Carpal Tunnel release Surgery

32370

REVISE- Diabesity

 14147

ROSE
Rivaroxaban Observational Safety Evaluation

13911

STAMP-2
Sedentary time and metabolic health in people with (or at risk of) type 2 diabetes

16105

STOP-CKD
Spironolactone to prevent Cardiovascular Events in Early Stage Chronic Kidney Disease: A pilot Trial

 13983

SUPPORT TIA
This study is part of a larger programme of research which aims to develop an intervention pathway to provide follow-up and support to improve the management of impairments and QoL post TIA/minor stroke

36290

TASMINH4 
Telemonitoring and/or self monitoring in hypertension (TASMINH4): A randomised controlled trial

16745

TIME
Treatment in Morning Versus Evening  - trial comparing evening dosing of usual anti-hypertensive therapy with conventional morning dose

17071

TIRCON
A randomized, doubleblind, placebocontrolled trial of deferiprone in patients with pantothenate kinaseassociated neurodegeneration (PKAN)

 15679

TWICS
A randomised, double-blind placebo controlled trial of the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease

 14832

Understanding vaccination uptake amongst Polish and Romanian migrants
Qualitative Interview study

34229

VTEC
VTE in care homes

 14555

We've Got Your BacK
The purpose of this study is to improve the understanding of back pain by capturing a large volume of daily symptoms and questionnaire data, through a phone based App