Cancer Predisposition Pathways

Molecular Oncology and genetics bannerStudying the Proteins and Post-translational modification pathways that protect our genome 

The Morris lab studies the way cells protect and repair DNA from damage. We want to know how these mechanisms are controlled by the cell; whether changes found in cancer affect the cellular response to DNA damage; and whether we can manipulate the damage response in order to find new avenues for cancer therapy. 

We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth. We use genome-wide profiling to screen different classes of cancer, such as colorectal cancer, for potential mutations and biomarkers. We study how cancer evolves, and are developing better molecular and cellular cancer models for designing and testing new therapies.

For example, Professor Andrew Beggs’ research is looking at devising organoid models to offer personalised medicine treatments for colorectal cancer patients, and Professor Richard Bryan is developing a 23-gene panel for a non-invasive diagnosis for bladder cancer.

Theme Lead


Professor Andrew Beggs

Professor in Surgery & Cancer Genetics


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Research groups

Cancer Genetics 
Professor Andrew Beggs                                                                     Colorectal cancer genetics and biology
Dr Professor Richard Bryan Bladder cancer biology and treatment
Professor Michael Griffiths Cancer genetics and mutation screening
Dr Claire Palles                                                                                   Gastrointestinal cancer genetics and epigenetics
Paediatric genetics and rare diseases 
Professor Timothy Barrett                             Paediatric genetics in diabetes
Cancer Biology and Pathology 
Dr Chiara Bardella                                                                                               Molecular mechanisms underlying glioma development
Dr Fedor Berditchevski Breast cancer tissue microenvironment
Professor Mathew Coleman Protein hydroxylation in cancer
Dr Lennard Lee       Molecular basis of cancer metastasis
Dr Carmel McConville Gene expression in neuronal cancer
Dr Elena Odintsova Breast cancer tissue microenvironment
Professor Andrew Peet Imaging in paediatric oncology
Dr Sovan Sarkar Autophagy in health and disease
Dr Chris Tselepis Colorectal cancer cell biology
Dr Richard Tuxworth Lysosomal storage diseases