Cancer Predisposition Pathways
Studying the Proteins and Post-translational modification pathways that protect our genome
The Morris lab studies the way cells protect and repair DNA from damage. We want to know how these mechanisms are controlled by the cell; whether changes found in cancer affect the cellular response to DNA damage; and whether we can manipulate the damage response in order to find new avenues for cancer therapy.
We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth. We use genome-wide profiling to screen different classes of cancer, such as colorectal cancer, for potential mutations and biomarkers. We study how cancer evolves, and are developing better molecular and cellular cancer models for designing and testing new therapies.
For example, Professor Andrew Beggs’ research is looking at devising organoid models to offer personalised medicine treatments for colorectal cancer patients, and Professor Richard Bryan is developing a 23-gene panel for a non-invasive diagnosis for bladder cancer.
Professor Andrew Beggs
Professor in Surgery & Cancer Genetics