Clinical Trials

Doctor with stethoscope and patient in bed

We develop new tools for diagnosing and treating cancer. The CRUK Clinical Trials Unit works together with clinicians to take advances in medicine and surgery forward to the clinic. We translate cutting edge science into improved patient care through the design of large multi-centre/international randomised trials as well as more data intensive Phase I trials of novel therapies.

Theme Lead

Pamela KearnsPamela Kearns

Professor of Clinical Paediatric Oncology

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Research groups

 

CRUK Clinical Trials Unit
Researcher Research area
Professor Lucinda Billingham Biostatistics and Clinical trials
Simon Gates Clinical trials
Piers Gaunt Clinical trials
Susanne Gatz Clinical trials
Aimee Jackson Clinical trials
Professor Pamela Kearns Paediatric oncology/Clinical trials
Sarah Pirrie Clinical trials
Professor Daniel Rea Breast cancer treatment
Daniel Slade Clinical trials
Professor Keith Wheatley Cancer clinical trials
Hematology and Oncology
Researcher Research area
Professor Charles Craddock                                                 Myeloid malignancies and stem cell transplantation
Professor Sean Kehoe Gynaecological cancer clinical trials
Dr Manoj Raghavan Myeloid malignancies

Spotlight on Lung Cancer

583:807-812 (2020). Middleton G, P Fletcher, S Popat, J Savage, Y Summers, A Greystoke, . . .and L Billingham. The National Lung Matrix Trial of personalized therapy in lung cancer.

Lung cancer image

A pioneering lung cancer study, led by the University of Birmingham’s Cancer Research UK Clinical Trials Unit, has highlighted important factors that will need to be considered in the next wave of precision medicine studies particularly in treating genomically complicated cancers.

The National Lung Matrix Trial (NLMT) is the world’s largest precision medicine clinical trial for non-small-cell lung cancer (NSCLC) patients.

Selected highlights from this research theme

Nature 583:807-812 (2020). Middleton G, P Fletcher, S Popat, J Savage, Y Summers, A Greystoke, . . . L Billingham. The National Lung Matrix Trial of personalized therapy in lung cancer. 

Lancet Respir Med 8:895-904 (2020). Middleton G, K Brock, J Savage, R Mant, Y Summers, J Connibear, . . . L Billingham. Pembrolizumab in patients with non-small-cell lung cancer of performance status 2 (PePS2): a single arm, phase 2 trial.