Cardiac Diseases

We are shaped by our genetic code, our environment, and by our actions. Our multidisciplinary research aims to understand how our genes, environment and lifestyle interact to affect the structure and function of our hearts. We use these insights to understand the factors which lead to and affect the outcomes of heart failure, atrial fibrillation, congenital heart disease, sudden cardiac death and myocardial infarction.

Davor Pavlovic-230x230Theme Lead

Dr Davor Pavlovic

Senior Lecturer in Cardiovascular Sciences

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Nigel Drury

Theme Lead

Mr Nigel Drury

Clinician Scientist in Paediatric Cardiac Surgery

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About our theme

In our Cardiac Diseases Theme we have a strong team of experienced clinical and non-clinical academics with multidisciplinary expertise in epidemiological research, data analysis, clinical trials, and translational (laboratory and clinical) science. Together, we develop approaches for integrated models of care and precision medicine for patients with cardiovascular conditions.

The cardiac diseases theme is made up of 25 individual PI-led research groups, bringing together experienced clinical and non-clinical academics with multidisciplinary expertise in epidemiological research, clinical trials, translational science and data analysis.

Our world leading researchers use clinical and translational approaches to address some of the key challenges in cardiovascular disease, from identifying the causes of disease through to improving the treatment options for patients. Our main areas of focus are atrial fibrillation, heart failure, structural heart disease, peripheral vascular disease and sudden death. We are also developing precision medicine approaches so that specific treatment can be adapted to the individual patient to improve prevention and treatment of these conditions. 

We work closely with the major NHS trusts across Birmingham including University Hospitals Birmingham NHS Foundation Trust, Sandwell and West Birmingham Hospitals NHS Trust, and Birmingham Women's and Children's NHS Foundation Trust, and through Birmingham Health Partners which greatly enhances our translational capabilities.

Our Principal Investigators and Research Groups

Research Groups

Translational Research on Heart Failure and Arrhythmias Cluster
Congential Heart Disease Research Group
Birmingham Cardio-Renal Research Group

DaRe2THINK is a transformational project that will test a new way of running clinical trials at General Practices in the NHS. The trial will use health information already collected in the NHS to reduce the time taken for research, both for the patients and NHS staff. This will allow the NHS to reach new and larger groups of patients that could benefit from new treatments opening the possibility of research to populations that would not have previously taken part.

Machine Learning and Artificial Intelligence (AI) for Early Detection of Stroke and Atrial Fibrillation (MAESTRIA) is a major international research programme which will develop a precise method to diagnose atrial cardiomyopathy, thereby providing clinicians with individualised clinical patient data to predict a patient's likelihood of suffering from subclinical AF, their future risk of AF and their overall risk of ischemic stroke with an accuracy that surpasses any currently available instrument.