Selected recent publications

Here is a selection of our recent high impact publications. To view the full range from our expert scientists on staff profiles visit the Our Staff page. 

 Selected recent publications
Author(s) Title Journal and date
El-Awaisi J, Kavanagh D.P.J, Rink M.R, Weston C.J, Drury N.E, and Kalia N Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/reperfusion injury in mice  JCI Insight. 2022;7(5):e155236.
O'Brien S, Holmes A.P, Johnson D.M,  Kabir S.N, O' Shea C, O' Reilly M, Avezzu A, Reyat J.S. Hall A.W, Apicella C, Ellinor P.T, Niederer S, Tucker N.R, Fabritz L, Kirchhof P and Pavlovic D.  Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels Journal of Molecular and Cellular Cardiology. January 31, 2022. DOI:
Ziegler M.J, Yserentant K, Dunsing V, Middel V, Gralak A.J, Pakari K, Bargstedt J, Kern C, Petrich A, Chiantia S, Strähle U, Herten D-P & Wombacher R Mandipropamid as a chemical inducer of proximity for in vivo applications Nat Chem Biol 18, 64–69 (2022).
Karwath A, Bunting K.V, Gill S.K, Tica O, Pendleton S, Aziz F, Barsky A.D, Chernbumroong S, Duan J, Mobley A.R, Cardoso V.R, Slater L, Williams J.A, Bruce E-J,  Wang X, Flather M.D, Coats A.J.S, Gkoutos G.V and Kotecha D on behalf of thecard AIc group and the Beta-blockers in Heart Failure Collaborative Group Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis The Lancet. VOLUME 398, ISSUE 10309, P1427-1435, Published:August 30, 2021DOI:
Navikas V, Leitao S.M, Grussmayer K.S, Descloux A, Drake B, Yserentant K, Werther P, Herten D-H, Wombacher W, Radenovic A & Fantner G.E. Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy Nat Commun 12, 4565 (2021).
Campos J, Ponomaryov T, Prendergast A.D,  Whitworth K, Smith C.W, Khan A.O, Kavanagh D and Brill A. Neutrophil extracellular traps and inflammasomes cooperatively promote venous thrombosis in mice Blood Adv 2021; 5 (9): 2319–2324. doi:
Bunting K.V, Stanbury M, Tica O and Kotecha D. Transforming clinical research by involving and empowering patients— the RATE-AF randomized trial European Heart Journal, Volume 42, Issue 25, 1 July 2021, Pages 2411–2414,
Scully M; Singh D,  Lown R, Poles A, Solomon T, Levi M, Goldblatt D, Kotoucek P, Thomas W, and Lester W Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination June 10, 2021N Engl J Med 2021; 384:2202-2211DOI: 10.1056/NEJMoa2105385
Jiang H, Hooper C, Kelly M, Steeples V, Simon J.N, Beglov J, Azad A.Z, Leinhos L, Bennett P, Ehler E, Kalisch-Smith J.I, Sparrow D.B, Fischer R, Heilig R, Isackson H, Ehsan M, Patone G, Huebner N, Davies B, Watkins H & Gehmlich K Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant Basic Res Cardiol 116, 14 (2021).
Hall C, Gehmlich K, Denning C and Pavlovic D. Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease 15 Feb 2021;; Journal of the American Heart Association. 2021;10:e019338
Price A.M, Moody W.E, Stoll V.M, Vijapurapu R, Hayer M.K, Biasiolli L, Weston C.J, Webster R,  Wesolowski R, McGee K.C, Liu B, Baig S, Pickup L.C, Radhakrishnan A, Law J.P, Edwards N.C, Steeds R.P, Ferro C.J and Townend J.N Cardiovascular Effects of Unilateral Nephrectomy in Living Kidney Donors at 5 Years 8 Feb 2021 2021;77:1273–1284
Chua W, Law J.P, Cardoso V.R, Purmah Y, Neculau G, Jawad-Ul-Qamar M, Russell K, Turner A, Tull S.P, Nehaj F, Brady P, Kastner P, Ziegler A, Gkoutos G.V, Pavlovic D, Ferro C.J, Kirchhof P, and Fabritz L. Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study PLOS Medicine 18(2): e1003405. Feb 2021
Slater A, Di Y, Clark J.C, Jooss N.J, Martin E.M, Alenazy F, Thomas M.R, Ariëns R.A.S, Herr A.B, Poulter N.S, Emsley J and Watson S.P. Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer Blood 2021; 137 (24): 3443–3453. doi:
Khan A.O, Slater A, Maclachlan A, Nicolson P.L.R, Pike J.A, Reyat J.S, Yule J, Stapley R, Rayes J, Thomas S.G and Morgan N.V Post-translational polymodification of β1-tubulin regulates motor protein localization in platelet production and function Haemotologica; Vol. 107 No. 1 (2022): January, 2022