Cardiovascular Translational Group in Hypertension, Myocardial Infarction and Heart Failure

Heart and blood vessels connected to it


Group leader: Dr Melanie Madhani

Overview

The main aim of our research is to identify novel targets and intervention for hypertension, myocardial infarction and heart failure. Dr Madhani’s group are bridging basic science and clinical research in cardiovascular disease.

Our research group

Despite advances in both knowledge and technology, coronary heart disease is the most common cause of death worldwide. Currently, substantial expenditure in the health service is directed towards restoring blood flow in patients with acute myocardial infarction (AMI) in order to limit myocardial injury. Whilst this has substantially reduced mortality, nevertheless the associated myocardial injury frequently leads to the development of heart failure that may develop either soon or after the index event.

Our internationally renowned research group is interested to understand the physiological and pathological actions of nitrite oxide, nitrite and cardiac metabolic agents in hypertension, myocardial infarction and heart failure. Currently, we have a broad range of translational research taking place in our group from “bench-to-bedside”.

Basic and Clinical Translational Research

  • Investigation of novel cardioprotective strategies and the role of nitrite in cardioprotection from bench to bedside (patients undergoing coronary artery bypass grafting surgery)
  • Assessment of vascular dysfunction in heart failure
  • Effect of cardiovascular disease on myocardial cellular signalling
Small resistance blood vessel from heart failure patient


Current Projects

Cardiovascular Translational Research from Bench to Bedside

  • Nitric oxide and nitrite as a therapeutic intervention for cardiovascular disease
  • Nitrite redox signalling in health and disease 
  • Cardiovascular Metabolism 

Recent Publications

Please view a full list of Dr Madhani’s publications

Nitrite and myocardial ischaemia reperfusion injury. Where are we now? Pharmacology & Therapeutics. Griffiths K, Lee JJ, Frenneaux MP, Feelisch, Madhani M 2021 223: 107819

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling. Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M. Cardiovasc Res. 2019 Jul 31.

A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, Wischmann P, Madhani M, Frenneaux MP, Postle AD, Cortese-Krott MM, Feelisch M. Redox Biol. 2018 Jun;16:359-380. doi: 10.1016/j.redox.2018.02.012. Epub 2018 Feb 19.

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation. Borgognone A, Shantsila E, Worrall SM, Prompunt E, Loka T, Loudon BL, Chimen M, Rainger GE, Lord JM, Turner A, Nightingale P, Feelisch M, Kirchhof P, Lip GYH, Watson SP, Frenneaux MP, Madhani M. Cardiovasc Res. 2018 Apr 12.

Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients. J O M Ormerod, S Arif, MMukadam, J D W Evans, R Beadle, B O Fernandez RS Bonser, M Feelisch, M Madhani*,M P Frenneaux* - *joint last authors.   Circulation Heart Failure. 2015 May: 8(3): 565-71

Cardiac metabolism - A promising therapeutic target for heart failure.Noordali H, Loudon BL, Frenneaux MP, Madhani M. Pharmacol Ther. 2018 Feb;182:95-114. doi: 10.1016/j.pharmthera.2017.08.001. Epub 2017 Aug 15.

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm. Loudon BL, Noordali H, Gollop ND, Frenneaux MP, Madhani M. Br J Pharmacol. 2016 Jun;173(12):1911-24. doi: 10.1111/bph.13480. Epub 2016 May 6.

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. J C Bailey, M Feelisch, J D Horowitz, M P Frenneaux, M Madhani.Pharmacol Ther. 2014 Jun 30.

Intravenous sodium nitrite in acute ST elevation myocardial infarction: a randomised controlled trial (NIAMI). N Siddiqi, M Bruce,CJ Neil,B Jagpal ,G Maclennon ,SC Cotton,SA Papadopoulo,N Bunce, L P, K Schwarz, S Singh ,D  Hildick-Smith, JD Horowitz, M Madhani, N Boon,JC Kaski,D Dawson,MP Frenneaux. European Heart Journal 2014 May 14; 35(19):1255-62.