Our established multi-disciplinary scientific excellence in thrombosis and haemostasis

Wound-plugging platelets captured forming inside the bone marrowThrombosis and Haemostasis encompasses a range of disorders which are collectively the major killers of mankind and are usually triggered by injury to blood vessels and inappropriate activation of platelets and the coagulation system inside a blood vessel. Our theme is made up of multiple individual research groups and brings together clinical and non-clinical academics with multidisciplinary expertise in discovery and translational science. We work very closely with the major NHS trusts across Birmingham including University Hospitals Birmingham, Sandwell and West Birmingham Hospitals and Birmingham Women's and Children's Hospitals, which greatly enhances our translational capabilities.

Dr Neil MorganTheme Lead

Professor Neil Morgan

Professor of Cardiovascular Genetics

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Dr Mark Thomas

Theme Lead

Dr Mark Thomas

NIHR Clinical Lecturer

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About the research

Our world leading researchers use basic science and translational approaches to address some of the key challenges in thrombosis and haemostasis. From identifying the causes of disease through to improving the treatments options for patients, we investigate platelet and megakaryocyte biology through the use of mouse models and cell biology. Our clinical studies focus on the genetics of patients with rare bleeding disorders and novel antithrombotic strategies for patients with thrombotic disorders.

Our Principal Investigators and Research Groups

Principal Investigators
Principal InvestigatorsResearch Interest
Professor Dirk-Peter Herten Molecular level signalling of inflammation and thrombo-inflammation
Professor Neil Morgan Identifying novel genes for inherited platelet disorders and associated bleeding and the underlying mechanisms
Professor Steve Watson Molecular mechanisms of platelet activation
Dr Alexander Brill Mechanisms of venous thrombosis and interplay between thrombosis and inflammation
Dr Abdullah Khan Developing organoid and organ-on-a-chip technologies to look at the effects of infection and cancer on tissue specific blood vessels and microenvironments
Dr Pip Nicholson Platelet activation, Venous Thromboembolism (VTE), Translational Medicine, Mass participation research
Dr Natalie Poulter Understanding platelet activation and receptor signalling using advanced microscopy
Dr Julie Rayes Understanding mechanisms of thromboinflammation in sterile and infectious conditions. In particular, I am interested in danger-associated molecular patterns effect on platelet and how it regulates its interaction with immune and endothelial cells
Dr Mark Thomas Antithrombotic pharmacology, precision medicine and machine learning
Dr Steve Thomas Platelet and Megakaryocyte Cytoskeletons, Advanced Fluorescent Microscopy
Honorary Principal Investigators
Principal InvestigatorsResearch Interest
Dr Gillian Lowe Inherited platelet disorders
Associate/Affiliate Principal Investigators
Associate/Affiliate Principal Investigators Research Interest
Professor Georgios Gkoutos Health Data Science, Bioinformatics, Artificial Intelligence for Health, Multmodal multiomics integrative analytics, Translational comparative phenomics, Precision Medicine
Dr Paul Harrison Platelets,  Neutrophils, Extracellular Vesicles, Trauma and Burns
Dr Patricia Lalor (Trish) Human liver inflammation and fibrosis, endothelial and platelet biology and impact of these on inflammation
Dr Michael Tomlinson Tetraspanins and associated membrane proteins

Research Groups

Birmingham Platelet Group