Led by the University of Birmingham and involving 15 European and US organisations, the PrecisionTox project blends technology and modern scientific approaches with law to establish a new cost-effective testing paradigm for chemical safety assessment — Precision Toxicology — that revolutionizes regulatory toxicology, replaces animal testing, reduces uncertainty, and determines safety factors in assessing risks to human health.
We accomplish this goal by identifying molecular toxicity pathways and their biomarkers that are shared among all animals by evolutionary descent. These are proven to be predictive of chemically induced adverse health effects in humans, and will feed directly into regulatory and industry practice to protect human health from the toxic effects of chemicals found in people’s homes, food and the environment.
The idea behind Precision Toxicology emerged from having witnessed — within a period of only 15 years — the healthcare revolution known as Precision Medicine, and recognizing the applicability and need for translation of this approach to toxicology.
Crucially, the research will be carried out without using mammalian animal testing, focusing instead on non-sentient organisms such as fruit flies, water fleas, round worms and embryos of zebrafish and frogs.
For more information on the Precision Toxicology project, contact Agata Ormanin.