CCB Virtual Seminar Series - Grigorios Papatzikas

         Understanding the metabolic signatures of haematological cancers through an integrative multi-Omics approach

Speaker: Grigorios Papatzikas

Title: Understanding the metabolic signatures of haematological cancers through an integrative multi-Omics approach

Abstract: Haematological cancers are heterogenous diseases caused by a series of events which disrupt the normal tissue architecture, driving cells to uncontrolled proliferation and tumour progression. Nowadays, our understanding is that cancer cells tend to reprogram their normal cellular metabolism to sustain their anabolic requirements for continuous cell growth and proliferation. Despite the remarkable progress in cancer metabolism, the exact mechanisms behind cancer metabolic reprogramming are not yet fully understood. The work presented in this thesis aims to provide novel biological insights into the metabolic reprogramming of haematological cancers and highlight potential metabolic vulnerabilities. A multi-Omics data integration approach was selected to achieve such ambitious aims. Herein, various recent computational methodologies were applied to integrate and analyse transcriptomic with metabolomic profiles derived from cancer patients, as well as cell lines, mostly from mature B-cell neoplasms, such as Chronic Lymphocytic Leukaemia (CLL) and Non-Hodgkin Lymphomas (NHL). Overall, this work portrays the power of multi-Omics data integration to unveil key elements in metabolic reprogramming of haematological cancers and raises numerous questions and new hypotheses for future metabolic studies.