Publications

Staff in the Centre collaborate with researchers around the world and contribute to a number of highly-rated scientific journals. A selection of recent articles can be found below: 

2020
 Title CitationLab Group

The genetic population structure of Robinson Crusoe Island, Chile

Mountford, H.S., Villanueva, P., Fernandez, M.A., Jara, L., De Barbieri, Z., Carvajal-Carmona, L.G., Cazier, J-B., Newbury, D.F. 

Frontiers in Genetics. 2020 June 26; 11:669.  https://doi.org/10.3389/fgene.2020.00669

Cazier

Coronavirus disease 2019: the pivotal role of UK clinical oncology and the UK Coronavirus Cancer Monitoring Project

Best, J., Starkey, T., Chaterjee, A., Fackrell, D., Pettit, L., Srihari, N., Tween, H., Olsson-Brown, A., Cheng, V., Hughes, D.J., Lee, A.J.X., Purshouse, K., Arnold, R., Palles, C., Sivakumar, S., Cazier, J-B., Lee, L.Y.W.

Clinical Oncology. 2020 June 5. https://doi.org/10.1016/j.clon.2020.05.021

Cazier

A genetic history of the Near East from an aDNA time course sampling eight points in the past 4,000 years

Haber, M., Nassar, J., Almarri, M.A., Saupe, T., Saag, L., Griffith, S.J., Doumet-Serhal, C., Chanteau, J., Saghieh-Beydoun, M., Xue, Y., Scheib, C.L., Tyler-Smith, C.

American Journal of Human Genetics. 2020 May 28. https://doi.org/10.1016/j.ajhg.2020.05.008

Haber

The UK Coronavirus Cancer Monitoring Project: protecting patients with cancer in the era of COVID-19

Anil, I., Arnold, R., Benkwitz-Bedford, S., Branford, S., Campton, N., Cazier, J-B., Cheng, V., Curley, H., D'Costa, J., Edmondson, A., Goel, A., Hartley, S., Hughes, D.J., Kerr, R., Lee, A., Lee, L.Y.W., Longworth, N., Middleton, C., Middleton, G., Naksukpaiboon, P., Olsson-Brown, A., Palles, C., Purshouse, K., Sandys, C., Sharma-Oates, A., Sivakumar, S., Smith, A., Starkey, T., Thompson, S., Varnai, C

The Lancet Oncology. 2020 April 15; 21(5):622-624. https://doi.org/10.1016/S1470-2045(20)30230-8

Cazier
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

Chung, P.E.D., Gendoo, D.M.A., Ghanbari-Azarnier, R., Liu, J.C., Jiang, Z., Tsui, J., Wang, D-Y., Xiao, X., Li, B., Dubuc, A., Shih, D., Remke, M., Ho, B., Garzia, L., Ben-David, Y., Kang, S-G., Croul, S., Haibe-Kains, B., Huang, A., Taylor, M.D., Zacksenhaus, E.

Nature Communications. 2020 April 14; 11 (1825). https://doi:10.1038/s41467-020-15585-2

Gendoo

Time extrapolation in regulatory risk assessment: the impact of study differences on the extrapolation factors

Escher, S., Mangelsdorf, I., Hoffmann-Doerr, S., Partosch, F., Karwath, A., Schröder, K., Zapf, A., Batke, M.

Regulatory Toxicology and Pharmacology. 2020 Apr;112(104584). https://doi:10.1016/j.yrtph.2020.104584

Karwath

Iron is a ligand of SecA-like metal-binding domains in vivo

Cranford-Smith, T., Jamshad, M., Jeeves, M., Chandler, R., Yule, J., Robinson, A., Alam, F., Dunne, K., Aponte Angarita, E., Alanazi, M., Carter, C., Henderson, I., Lovett, J., Winn, P., Knowles, T., Huber, D.

Journal of Biological Chemistry. 2020 Mar 30. https://doi:10.1074/jbc.RA120.012611

Winn

Parental-to-embryo switch of chromosome organization in early embryogenesis

Collombet, S., Ranisavljevic, N., Nagano, T., Varnai, C., Shisode, T., Leung, W., Piolot, T., Galupa, R., Borensztein, M., Servant, N., Fraser, P., Ancelin, K., Heard, E.

Nature. 2020 Mar 25. 580:142–146. https://doi.org/10.1038/s41586-020-2125-z 

Cazier
Assessment of endoscopic healing by using advanced technologies reflects histologic healing in ulcerative colitis

Iacucci, M., Ghosh, S., Cannatelli, R., Gui, X. S., Bazarova, A., Zardo, D., Gkoutos, G., Lethebe, B. C., Kaplan, G. G., Panaccione, R., Kiesslich, R. & Ghosh, S. 

Journal of Crohn's & Colitis. 2020 Mar 23. https://doi:10.1093/ecco-jcc/jjaa056 [Epub ahead of print]

Gkoutos

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Merker M., Kohl T. A., Barilar I., Andres S., Fowler P., Chryssanthou E., Ängeby K., Jureen P., Moradigaravand D., Parkhill J., Peacock S. J., Schön T., Maurer F., Walker T., Köser C., Niemann S.

Genome Medicine. 2020 Mar 6;12(1):27. https://doi.org/10.1186/s13073-020-00726-5

Moradigaravand

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

Wutz, G., Ladurner, R., Glenn St Hilaire, B., Stocsits, R.R., Nagasaka, K., Pignard, B., Sanborn, A., Tang, W., Varnai, C., Ivanov, M.P., Schoenfelder, S., van der Lelij, P., Huang, X., Dürnberger, G., Roitinger, E., Mechtler, K., Davidson, I.F., Fraser, P., Lieberman-Aiden, E., Peters, J-M.

Elife. 2020 Feb 17; 9: e52091. https://doi:10.7554/eLife.52091

Cazier

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression

Kwok, M.C.K., Oldreive, C., Rawstron, A.C., Goel, A., Papatzikas, G., Jones, R., Drennan, S., Agathanggelou, A., Sharma-Oates, A., Evans, P., Smith, E., Dalal, S., Mao, J., Hollows, R., Gordon, N., Hamada, M., Davies, N., Parry, H., Beggs, A., Munir, T., Moreton, P., Paneesha, S., Pratt, G., Taylor, M., Forconi, F., Baird, D., Cazier, J-B., Moss, P., Hillmen, P. & Stankovic, T.

Blood. 2020 Feb 6;135(6):411-428. https://doi:10.1182/blood.2019001262

Cazier
Bioinformatics and computational approaches for analyzing patient-derived disease models in cancer research

Gendoo, D.M.A. 

Computational and Structural Biotechnology Journal. 2020 Feb 5;18:375-380. https://doi:10.1016/j.csbj.2020.01.010

Gendoo
A pilot integrative analysis of colonic gene expression, gut microbiota and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways

Quraishi, M.N., Acharjee, A., Beggs, A. D., Horniblow, R., Tselepis, C., Gkoutos, G., Ghosh, S., Rossiter, A., Loman, N., van Schaik, W., Withers, D., Walters, J.R. F., Hirschfield, G.M. & Iqbal, T.H.

Journal of Crohn's & Colitis. 2020 Feb 4. https://doi:10.1093/ecco-jcc/jjaa021

Gkoutos
A multicentre development and validation study of a novel Lower Gastrointestinal Bleeding score - The Birmingham Score

Smith, S., Bazarova, A., Ejenavi, E., Qurashi, M., Shivaji, U., Harvey, P.R., Slaney, E., McFarlane, M., Baker, G., Elnagar, M., Yuzari, S., Gkoutos, G.V., Ghosh, S. & Iacucci, M.

International Journal of Colorectal Disease. 2020 Feb;35(2):285-293. https://doi:10.1007/s00384-019-03459-z

Gkoutos
Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, traveling wave ion mobility spectrometry, and molecular modeling

Simmonds, A., Lopez-Clavijo, A., Winn, P., Russell, D., Styles, I. & Cooper, H.

Journal of Physical Chemistry B. 2020 Jan 23;124(3):461-469. https://doi:10.1021/acs.jpcb.9b08506

Winn
A one health study of the genetic relatedness of Klebsiella pneumoniae and their mobile elements in the East of England

Ludden C., Moradigaravand D.

Clinical Infectious Diseases. 2020 Jan 15;70(2):219-226.  https://doi:10.1093/cid/ciz174

Moradigaravand