Publications

Staff in the Centre collaborate with researchers around the world and contribute to a number of highly-rated scientific journals. A selection of recent articles can be found below: 

2022
 Title                                                                                                          Citation Lab Group

Application of T-cell receptor repertoire as a novel monitor in dynamic tracking and assessment: A cohort-study based on RA patients

Yang, P., He, Y., Qing, P., Xu, W., Xie, D., Cazier, JB., Liu, X., Varnai, C., Zhou, Y.,  Zhao, Y., Tang, H., Yin, X.,Liu, Y.

Journal of Cellular and Molecular Medicine
2022 November 28
https://doi.org/10.1111/jcmm.17623

 Cazier
 

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank.

Kany S, Cardoso VR, Bravo L, Williams JA, Schnabel R, Fabritz L, Gkoutos GV, Kirchhof P.

Heart
2022 November 10

doi: 10.1136/heartjnl-2022-321196

 Gkoutos

Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins

 

Leeuwin, J., al-Alwi, W., Branchard, E., Cruickshank, J., Schormann, W., Longo, J., Silvester, J., Gross, P., Andrews, D., Cescon, D., Haibe-Kains, B., Penn, L., Gendoo, D.

Nature Communications
2022 October 26
https://doi.org/10.1038/s41467-022-33144-9

  Cazier

Early onset of immune-mediated diseases in minority ethnic groups in the UK

 

Sharma-Oates, A., Zemedikun, D., Kumar, K., Reynolds, J., Jain, A., Raza, K., Williams, J., Bravo, L., Cardoso, V., Gkoutos, G., Nirantharakumar, K., Lord, J.

BMC Medicine
2022 October 13
https://doi.org/10.1186/s12916-022-02544-5

 Gkoutos

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research.

 

Kotecha D, Asselbergs FW, Achenbach S, Anker SD, Atar D, Baigent C, Banerjee A, Beger B,Brobert G, Casadei B, Ceccarelli C, Cowie MR, Crea F,Cronin M, Denaxas S, Derix A, Fitzsimons D, Fredriksson M, Gale CP, Gkoutos GV, Goettsch W, Hemingway H, Ingvar M, Jonas A, Kazmierski R, Løgstrup S, Thomas Lumbers R, Lüscher TF, McGreavy P, Piña IL, Roessig L, Steinbeisser C, Sundgren M, Tyl B, van Thiel G, van Bochove K, Vardas PE, Villanueva T, Vrana M, Weber W, Weidinger F, Windecker S, Wood A, Grobbee DE.

Published across multiple journals:
Eur Heart J.
BMJ
Lancet Digital Health
2022 August
https://doi.org/10.1016/S2589-7500(22)00151-0

 Gkoutos

Symptoms and risk factors for long COVID in non-hospitalized adults.

Subramanian A, Nirantharakumar K, Hughes S, Myles P, Williams T, Gokhale KM, Taverner T, Chandan JS, Brown K, Simms-Williams N, Shah AD, Singh M, Kidy F, Okoth K, Hotham R, Bashir N, Cockburn N, Lee SI, Turner GM, Gkoutos GV, Aiyegbusi OL, McMullan C, Denniston AK, Sapey E, Lord JM, Wraith DC, Leggett E, Iles C, Marshall T, Price MJ, Marwaha S, Davies EH, Jackson LJ, Matthews KL, Camaradou J, Calvert M, Haroon S.

Nature Medicine
2022 August
https://doi.org/10.1038/s41591-022-01909-w

 Gkoutos

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements

Baranasic, D.,  Hörtenhuber, M., Balwierz, P., Zehnder, T., Mukarram, A.,
Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D’Orazio, F., Relic, D., Mikhail Pachkov, Noelia Díaz, Benjamín Hernández-Rodríguez, Zelin Chen, Marcus Stoiber, Michaël Dong, Irene Stevens, Samuel E. Ross, Anne Eagle, Ryan Martin, Oluwapelumi Obasaju, Sepand Rastegar, Alison C. McGarvey, Wolfgang Kopp, Emily Chambers, Dennis Wang, Hyejeong R. Kim, Rafael D. Acemel, Silvia Naranjo, Maciej Łapiński, Vanessa Chong, Sinnakaruppan Mathavan, Bernard Peers, Tatjana Sauka-Spengler, Martin Vingron, Piero Carninci, Uwe Ohler, Scott Allen Lacadie, Shawn M. Burgess, Cecilia Winata, Freek van Eeden, Juan M. Vaquerizas, José Luis Gómez-Skarmeta, Daria Onichtchouk, Ben James Brown, Ozren Bogdanovic, Erik van Nimwegen, Monte Westerfield, Fiona C. Wardle, Carsten O. Daub, Lenhard, B., Müller, F. 

Nature Genetics
2022 July 4
https://doi.org/10.1038/s41588-022-01089-w 

  Cazier

Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide

 

Irvine, H., Acharjee,A., Wolcott, z., Simard, J., Sheth, K., Kimberley, W. 

Cell Reports Medicine
2022 June 13
https://doi.org/10.1016/j.xcrm.2022.100654

 Gkoutos

Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes

Goel, A., Ward, D.,Noyvert, B., Yu, M., Gordon, N., Abbotts, B., Colbourne, J.,  Kissane, S., James, Zeegers, M., Cheng, K., Cazier, J., Whalley, C., Beggs, A., Palles, C., Arnold, R., Bryan, R.

Genome Medicine
2022 June 03.
https://doi.org/10.1186/s13073-022-01056-4

 Cazier

Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders

Williams JA, Burgess S, Suckling J, Lalousis PA, Batool F, Griffiths SL, Palmer E, Karwath A, Barsky A, Gkoutos GV, Wood S, Barnes NM, David AS, Donohoe G, Neill JC, Deakin B, Khandaker GM, Upthegrove R

JAMA Psychiatry
2022 May
https://doi: 10.1001/jamapsychiatry.2022.0407.

 Gkoutos 
Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors

Nieto, H., Thornton, C., Brookes, K., Menezes, A., Fletcher, A., Alshahrani, M., Kocbiyik, M., Sharma, N., Boelaert, K.,  Cazier, J., Mehanna, H., Smith, V., Read, M., McCabe C. 

The Journal of Clinical Endocrinology & Metabolism
2022 May.
https://doi.org/10.1210/clinem/dgab836

 Cazier
Interdisciplinary and Transferable Concepts in Bioinformatics Education: Observations and Approaches From a UK MSc Course.

Johnston, I., Slater, M., Cazier, J. 

Frontiers in Education
2022 Feb 24.
https://doi.org/10.3389/feduc.2022.826951

 Cazier

Fine-scale genetic structure in the united arab emirates reflects endogamous and consanguineous culture, population history and geography

Cazier

Mortality Among Adults With Cancer Undergoing Chemotherapy  or Immunotherapy and Infected With COVID-19                                                                                                                                                                      

Cazier

The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma

Bosch, S., Acharjee, A., Quraishi, M., Rojas, P., Bakkali, A., Jansen, E., Brentar, M., Kuijvenhoven, J., Stokkers, P., Struys, E., Beggs, A., Gkoutos, G., Meij, T., Boer, N.

Gut Microbes
2022 Feb 21.
https://doi.org/10.1080/19490976.2022.2038863

 Gkoutos

Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models

Russ, D., Williams, J., Roth Cardoso, V., Bravo-Merodio, L., Pendleton, S., Aziz, F., Acharjee, A., Gkoutos, G.

PLOS ONE
2022 Feb 18.
https://doi.org/10.1371/journal.pone.0263390

  Gkoutos

Prediction models in first episode psychosis: a systematic review and critical appraisal

 Gkoutos

Integration of metabolomic and clinical data improves the prediction of intensive care unit length of stay following major traumatic injury

Acharjee, A., Hazeldine, J., Bazarova, A., Deenadayalu, L., Zhang, J., Bentley, C., Russ, D., Lord, J. M., Gkoutos, G. V., Young, S. P., Foster, M. A. 

Metabolites
2022 Jan.
https://doi.org/10.3390/metabo12010029

 

 Gkoutos 
P., 

2021
 Title CitationLab Group

Prediction models in first episode psychosis: a systematic review and critical appraisal

Gkoutos

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila

Weber

Ultra-high magnification endocytoscopy and molecular markers for defining endoscopic and histologic remission in ulcerative colitis—an exploratory study to define deep remission

Gkoutos

Multi-faceted semantic clustering with text-derived phenotypes

Luke T Slater, John A Williams, Andreas Karwath, Hilary Fanning, Simon Ball, Paul N Schofield, Robert Hoehndorf, Georgios V Gkoutos

Computers in Biology Medicine
2021 Nov.
https://doi.org/10.1016/j.compbiomed.2021.104904

  Gkoutos

Immediate sample fixation increases Circulating Tumour Cell (CTC) capture and preserves phenotype in head and neck squamous cell carcinoma: towards a standardised approach to microfluidic CTC biomarker discovery

Cazier

The genomic history of the Middle East.

Haber

Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis

 Gkoutos
Paediatric major incident triage: UK military tool offers best performance in predicting the need for time-critical major surgical and resuscitative intervention

Malik, N. S., Chernbumroong, S., Xu, Y., Vassallo, J., Lee, J., Moran, C. G., Newton, T., Arul, G. S., Lord, J. M., Belli, A., Keene, D., Foster, M., Hodgetts, T., Bowley, D. M., Gkoutos, G. V

EClinicalMedicine
2021 Oct.
https://doi.org/10.1016/j.eclinm.2021.101100

 Gkoutos
NFnetFu: A novel workflow for microbiome data fusion

Bisht, V., Acharjee, A., Gkoutos, G. 

Computers in Biology and Medicine
2021 Aug.
https://doi.org/10.1016/j.compbiomed.2021.104556

 Gkoutos 
Multimorbidity prediction using link prediction

Aziz, F., Roth Cardoso, V., Bravo-Merodio, L., Russ, D., Pendleton, S., Williams, J., Acharjee, A., Gkoutos, G.

Scientific Reports
2021 Aug 12.
https://doi.org/10.1038/s41598-021-95802-0

 Gkoutos
COVID-19 in children with haematological malignancies

Millen, G. C., Arnold, R., Cazier, J., Curley, H., Feltbower, R., Gamble, A., Glaser, A., Grundy, R. G., Kirton, L., Lee, L. Y. W., McCabe, M. G., Palles, C., Phillips, B., Stiller, C. A., Varnai, C., Kearns, P.

Archives of Disease in Childhood
2021 Jul 22.
https://doi.org/10.1136/archdischild-2021-322062

 Cazier
The BCD Triage Sieve outperforms all existing major incident triage tools: comparative analysis using the UK national trauma registry population

Malik, N. S., Chernbumroong, S., Xu, Y., Vassallo, J., Lee, J., Bowley, D. M., Hodgetts, T., Moran, C. G., Lord, J. M., Belli, A., Keene, D., Foster, M., Gkoutos, G. V. 

EClinicalMedicine
2021 Jun.
https://doi.org/10.1016/j.eclinm.2021.100888

 Gkoutos

Eye movements in patients in early psychosis with and without a history of cannabis use

Musa Basseer Sami, Luciano Annibale, Aisling O’Neill, Tracy Collier, Chidimma Onyejiaka, Savitha Eranti, Debasis Das, Marlene Kelbrick, Philip McGuire, Steve C. R. Williams, Anas Rana, Ulrich Ettinger & Sagnik Bhattacharyya 

Nature
2021 May 12.
https://doi.org/https://doi.org/10.1038/s41537-021-00155-2

 Rana
Improved characterisation of clinical text through ontology-based vocabulary expansion

Slater, L. T., Bradlow, W., Ball, S., Hoehndorf, R., Gkoutos, G. V.

Journal of Biomedical Semantics
2021 Apr 12.
https://doi.org/10.1186/s13326-021-00241-5

 Gkoutos

PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity

Parry, H. M., Dowell, A. C., Zuo, J., Verma, K., Kinsella, F. A. M., Begum, J., Croft, W., Sharma-Oates, A., Pratt, G., Moss, P.

PLoS pathogens
2021 Mar 4.
https://doi.org/10.1371/journal.ppat.1009349

 Cazier
Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: a validation study

Chua, W., Law, J. P., Cardoso, V. R., Purmah, Y., Neculau, G., Jawad-Ul-Qamar, M., Russell, K., Turner, A., Tull, S. P., Nehaj, F., Brady, P., Kastner, P., Ziegler, A., Gkoutos, G. V., Pavlovic, D., Ferro, C. J., Kirchhof, P., Fabritz, L.

PLoS Medicine
2021 Feb 3.
https://doi.org/10.1371/journal.pmed.1003405

 Gkoutos
Effects of Negation and Uncertainty Stratification on Text-Derived Patient Profile Similarity

Slater, L. T., Karwath, A., Hoehndorf, R., Gkoutos, G. V.

Frontiers in digital health
2021
https://doi.org/10.3389/fdgth.2021.781227

 Gkoutos
2020
 Title CitationLab Group

Uric acid and gluconic acid as predictors of hyperglycemia and cytotoxic injury after stroke

 Gkoutos

Translational biomarkers in the era of precision medicine

Bravo-Merodio, L., Acharjee, A., Russ, D., Bisht, V., Williams, J.A., Tsaprounie, L.G., Gkoutos, G.V.

 

Advances in Clinical Chemistry.

2020 Oct 3.

https://doi.org/10.1016/bs.acc.2020.08.002

 Gkoutos

Ethnicity-based differences in the incident risk of allergic diseases and autoimmune disorders: a UK-based retrospective cohort study of 4.4million participants

Subramanian, A., Adderley, N., Gkoutos, G., Margadhamane Gokhale, K., Nirantharakumar, K., Krishna, M.

 

Clinical and Experimental Allergy.
2020 Sep 18.

https://doi.org/10.1111/cea.13741

 

 Gkoutos

COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Lee, L.Y.W.*, Cazier, J-B.*, Starkey, T.*, Briggs, S.E.W., Arnold, R., Bisht, V., Booth, S., Campton, N.A., Cheng, V.W.T., Collins, G., Curley, H.M., Earwaker, P., Fittall, M.W., Gennatas, S., Goel, A., Hartley, S., Hughes, D.J., Kerr, D., Lee, A.J.X., Lee, R.J., Lee, S.M., McKenzie, H., Middleton, C.P., Murugaesu, N., Newsom-Davis, T., Olsson-Brown, A.C., Palles, C., Powles, T., Protheroe, E.A., Purshouse, K., Sharma-Oates, A., Sivakumar, S., Smith, A.J., Topping, O., Turnbull, C.D., Várnai, C., Briggs, A.D.M., Middleton, G.†, Kerr, R.†   (* joint first author, † joint senior author)

The Lancet Oncology.
2020 Aug 24;21(10):1309-1316.
https://doi.org/10.1016/S1470-2045(20)30442-3

 Cazier

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

 

Reyat, J. S., Chua, W., Cardoso, V. R., Witten, A., Kastner, P. M., Kabir, S. N., Sinner, M. F., Wesselink, R., Holmes, A. P., Pavlovic, D., Stoll, M., Kääb, S., Gkoutos, G. V., de Groot, J. R., Kirchhof, P. & Fabritz, L.

 

JCI Insight.

2020 Aug 20; 5(16):e139179. https://doi.org/10.1172/jci.insight.139179

 Gkoutos 

Target Product Profile for an endometrial receptivity test: women's perspective

Craciunas, L., Pickering, O., Chu, J., Žurauskienė, J., Coomarasamy, A.

European Journal of Obstetrics & Gynecology and Reproductive Biology.
2020 Aug 1;253:42-47. https://doi.org/10.1016/j.ejogrb.2020.07.058

 Cazier

The consequences of lipid remodelling of adipocyte membranes being functionally distinct from lipid storage in obesity

Liu, K., Acharjee, A., Hinz, C., Liggi, S., Murgia, A., Denes, J., Gulston, M.K., Wang, X., Chu, Y., West, J.A., Glen, R.C., Roberts, L.D., Murray, A.J., Griffin, J.L.

Journal of Proteome Research.
2020 Jul 9;19(10):3919–3935. 
https://doi.org/10.1021/acs.jproteome.9b00894

 Gkoutos

Core regulatory circuitries in defining cancer cell identity across the malignant spectrum

Jahangiri, L., Tsaprouni, L., Trigg, R. M., Williams, J. A., Gkoutos, G. V., Turner, S. D. & Pereira, J.

Open Biology.
2020 Jul 8;10(7):200121. 
https://doi.org/10.1098/rsob.200121

 Gkoutos

Functional movements of the GABA type A receptor

Várnai, C., Irwin, B.W.J., Payne, M.C., Csányi, G., Chau, P.-L.

Physical Chemistry Chemical Physics.
2020 Jul 7;22(28):16023-16031.
https://doi.org/10.1039/D0CP01128B

 Cazier

Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size

Lipunova, N., Wesselius, A., Cheng, K. K., van Schooten, F-J., Bryan, R. T., Cazier, J-B., Zeegers, M. P.

Translational Andrology and Urology.
2020 Jun 30;9(3):1329-1337.
https://doi.org/10.21037/tau-19-523

 Cazier

The genetic population structure of Robinson Crusoe Island, Chile

Mountford, H.S., Villanueva, P., Fernandez, M.A., Jara, L., De Barbieri, Z., Carvajal-Carmona, L.G., Cazier, J-B., Newbury, D.F. 

Frontiers in Genetics.
2020 Jun 26;11:669. 
https://doi.org/10.3389/fgene.2020.00669

 Cazier

Machine learning for high-throughput field phenotyping and image processing provides insight into the association of above and below-ground traits in cassava (Manihot esculenta Crantz)

Selvaraj, M.G., Valderrama, M., Guzman, D., Valencia, M., Ruiz, H., Acharjee, A.

Plant Methods.
2020 Jun 14;16:87. 
https://doi.org/10.1186/s13007-020-00625-1 

 Gkoutos

Radiomic analysis of native T1 mapping images discriminates between MYH7 and MYBPC3-related hypertrophic cardiomyopathy

Wang, J., Yang, F., Liu, W., Sun, J., Han, Y., Li, D., Gkoutos, G. V., Zhu, Y. & Chen, Y.

Journal of Magnetic Resonance Imaging.
2020 Jun 11.
https://doi.org/10.1002/jmri.27209

 Gkoutos

Coronavirus disease 2019: the pivotal role of UK clinical oncology and the UK Coronavirus Cancer Monitoring Project

Best, J., Starkey, T., Chaterjee, A., Fackrell, D., Pettit, L., Srihari, N., Tween, H., Olsson-Brown, A., Cheng, V., Hughes, D.J., Lee, A.J.X., Purshouse, K., Arnold, R., Palles, C., Sivakumar, S., Cazier, J-B., Lee, L.Y.W.

Clinical Oncology.
2020 Jun 5.
https://doi.org/10.1016/j.clon.2020.05.021

 Cazier

COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study

Lee, L.Y.W.*, Cazier, J-B.*, Angelis, V., Arnold, R., Bisht, V., Campton, N.A., Chackathayil, J., Cheng V.W.T., Curley, H.M., Fittall, M.W., Freeman-Mills, L., Gennatas, S., Goel, A., Hartley, S., Hughes D.J., Kerr, D., Lee, A.J.X., Lee, R.J., McGrath, S.E., Middleton, C.P., Murugaesu, N., Newsom-Davis, T., Okines, A.F.C., Olsson-Brown, A.C., Palles, C., Pan, Y., Pettengell, R., Powles, T., Protheroe, E.A., Purshouse, K., Sharma-Oates, A., Sivakumar, S., Smith, A.J., Starkey, T., Turnbull, C.D., Várnai, C., Yousaf, N., UK CCMP, Kerr, R.†, Middleton, G.†   (* joint first author, † joint senior author) 

The Lancet.
2020 May 28;395(10241):1919-1926.
https://doi.org/10.1016/S0140-6736(20)31173-9

 Cazier

A genetic history of the Near East from an aDNA time course sampling eight points in the past 4,000 years

Haber, M., Nassar, J., Almarri, M.A., Saupe, T., Saag, L., Griffith, S.J., Doumet-Serhal, C., Chanteau, J., Saghieh-Beydoun, M., Xue, Y., Scheib, C.L., Tyler-Smith, C.

American Journal of Human Genetics.
2020 May 28;107(1):149-157.
https://doi.org/10.1016/j.ajhg.2020.05.008

 Haber

Prevalence of admission plasma glucose in 'diabetes' or 'at risk' ranges in hospital emergencies with no prior diagnosis of diabetes by gender, age and ethnicity

Ghosh, S., Manley, S. E., Nightingale, P. G., Williams, J. A., Susarla, R., Alonso‐Perez, I., Stratton, I. M., Gkoutos, G. V., Webber, J., Luzio, S. D., Hanif, W., Roberts, G. A.

Endocrinology, Diabetes & Metabolism.
2020 May 15;3(3). 
https://doi.org/10.1002/edm2.140

 Gkoutos

The UK Coronavirus Cancer Monitoring Project: protecting patients with cancer in the era of COVID-19

Anil, I., Arnold, R., Benkwitz-Bedford, S., Branford, S., Campton, N., Cazier, J-B., Cheng, V., Curley, H., D'Costa, J., Edmondson, A., Goel, A., Hartley, S., Hughes, D.J., Kerr, R., Lee, A., Lee, L.Y.W., Longworth, N., Middleton, C., Middleton, G., Naksukpaiboon, P., Olsson-Brown, A., Palles, C., Purshouse, K., Sandys, C., Sharma-Oates, A., Sivakumar, S., Smith, A., Starkey, T., Thompson, S., Várnai, C. 

The Lancet Oncology.
2020 Apr 15;21(5):622-624.
https://doi.org/10.1016/S1470-2045(20)30230-8

 Cazier
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

Chung, P.E.D., Gendoo, D.M.A., Ghanbari-Azarnier, R., Liu, J.C., Jiang, Z., Tsui, J., Wang, D-Y., Xiao, X., Li, B., Dubuc, A., Shih, D., Remke, M., Ho, B., Garzia, L., Ben-David, Y., Kang, S-G., Croul, S., Haibe-Kains, B., Huang, A., Taylor, M.D., Zacksenhaus, E.

Nature Communications.
2020 Apr 14;11:1825.
https://doi.org/10.1038/s41467-020-15585-2

 Gendoo

Time extrapolation in regulatory risk assessment: the impact of study differences on the extrapolation factors

Escher, S., Mangelsdorf, I., Hoffmann-Doerr, S., Partosch, F., Karwath, A., Schröder, K., Zapf, A., Batke, M.

Regulatory Toxicology and Pharmacology.
2020 Apr;112:104584.
https://doi.org/10.1016/j.yrtph.2020.104584

 Karwath

Iron is a ligand of SecA-like metal-binding domains in vivo

Cranford-Smith, T., Jamshad, M., Jeeves, M., Chandler, R., Yule, J., Robinson, A., Alam, F., Dunne, K., Aponte Angarita, E., Alanazi, M., Carter, C., Henderson, I., Lovett, J., Winn, P., Knowles, T., Huber, D.

Journal of Biological Chemistry.
2020 Apr 2;295:7516-7528. 
https://doi.org/10.1074/jbc.RA120.012611

 Winn

Parental-to-embryo switch of chromosome organization in early embryogenesis

Collombet, S., Ranisavljevic, N., Nagano, T., Várnai, C., Shisode, T., Leung, W., Piolot, T., Galupa, R., Borensztein, M., Servant, N., Fraser, P., Ancelin, K., Heard, E.

Nature.
2020 Mar 25;580:142–146.
https://doi.org/10.1038/s41586-020-2125-z 

 Cazier
Assessment of endoscopic healing by using advanced technologies reflects histologic healing in ulcerative colitis

Iacucci, M., Ghosh, S., Cannatelli, R., Gui, X. S., Bazarova, A., Zardo, D., Gkoutos, G., Lethebe, B. C., Kaplan, G. G., Panaccione, R., Kiesslich, R. & Ghosh, S. 

Journal of Crohn's & Colitis.
2020 Mar 23;14(9):1282-1289. 
https://doi.org/10.1093/ecco-jcc/jjaa056

 Gkoutos

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Merker M., Kohl T. A., Barilar I., Andres S., Fowler P., Chryssanthou E., Ängeby K., Jureen P., Moradigaravand D., Parkhill J., Peacock S. J., Schön T., Maurer F., Walker T., Köser C., Niemann S.

Genome Medicine.
2020 Mar 6;12(1):27.
https://doi.org/10.1186/s13073-020-00726-5

 Moradigaravand

Violence-related knife injuries in a UK city; epidemiology and impact on secondary care resources

Malik, N.S., Munoz, B., de Courcey, C., Imran, R., Lee, K.C., Chernbumroong, S., Bishop, J., Lord, J.M., Gkoutos, G., Bowley, D.M., Foster, M.A.

EClinicalMedicine.
2020 Mar 3;20:100296. 
https://doi.org/10.1016/j.eclinm.2020.100296

 Gkoutos

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

Wutz, G., Ladurner, R., Glenn St Hilaire, B., Stocsits, R.R., Nagasaka, K., Pignard, B., Sanborn, A., Tang, W., Várnai, C., Ivanov, M.P., Schoenfelder, S., van der Lelij, P., Huang, X., Dürnberger, G., Roitinger, E., Mechtler, K., Davidson, I.F., Fraser, P., Lieberman-Aiden, E., Peters, J-M.

Elife.
2020 Feb 17;9:e52091.
https://doi.org/10.7554/eLife.52091

 Cazier

Epidemiology, morbidity and mortality in Behçet’s disease: a cohort study using The Health Improvement Network (THIN)

Thomas, T., Chandan, J.S., Subramanian, A., Gokhale, K., Gkoutos, G., Harper, L., Buckley, C., Chandratre, P., Raza, K., Situnayake, D., Nirantharakumar, K.

Rheumatology.
2020 Feb 10;59(10):2785-2795.
https://doi.org/10.1093/rheumatology/keaa010

 Gkoutos

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression

Kwok, M.C.K., Oldreive, C., Rawstron, A.C., Goel, A., Papatzikas, G., Jones, R., Drennan, S., Agathanggelou, A., Sharma-Oates, A., Evans, P., Smith, E., Dalal, S., Mao, J., Hollows, R., Gordon, N., Hamada, M., Davies, N., Parry, H., Beggs, A., Munir, T., Moreton, P., Paneesha, S., Pratt, G., Taylor, M., Forconi, F., Baird, D., Cazier, J-B., Moss, P., Hillmen, P. & Stankovic, T.

Blood. 
2020 Feb 6;135(6):411-428.
https://doi.org/10.1182/blood.2019001262

 Cazier
Bioinformatics and computational approaches for analyzing patient-derived disease models in cancer research

Gendoo, D.M.A. 

Computational and Structural Biotechnology Journal.
2020 Feb 5;18:375-380. 
https://doi.org/10.1016/j.csbj.2020.01.010

 Gendoo
A pilot integrative analysis of colonic gene expression, gut microbiota and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways

Quraishi, M.N., Acharjee, A., Beggs, A. D., Horniblow, R., Tselepis, C., Gkoutos, G., Ghosh, S., Rossiter, A., Loman, N., van Schaik, W., Withers, D., Walters, J.R. F., Hirschfield, G.M. & Iqbal, T.H.

Journal of Crohn's & Colitis.
2020 Feb 4;14(7):935-947.
https://doi.org/10.1093/ecco-jcc/jjaa021

 Gkoutos
A multicentre development and validation study of a novel Lower Gastrointestinal Bleeding score - The Birmingham Score

Smith, S., Bazarova, A., Ejenavi, E., Qurashi, M., Shivaji, U., Harvey, P.R., Slaney, E., McFarlane, M., Baker, G., Elnagar, M., Yuzari, S., Gkoutos, G.V., Ghosh, S. & Iacucci, M.

International Journal of Colorectal Disease.
2020 Feb;35:285-293.
https://doi.org/10.1007/s00384-019-03459-z

 Gkoutos
Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, traveling wave ion mobility spectrometry, and molecular modeling

Simmonds, A., Lopez-Clavijo, A., Winn, P., Russell, D., Styles, I. & Cooper, H.

Journal of Physical Chemistry B.
2020 Jan 23;124(3):461-469.
https://doi.org/10.1021/acs.jpcb.9b08506

 Winn

P005 Regulators of the guanylate cyclase pathway are potential novel markers of mucosal healing in IBD

Jeffery, L. E., Shivaji, U. N., Zardo, D., Acharjee, A., Nardone, O. M., Smith, S. C., Gkoutos, G., Visweswariah, S. S., Ghosh, S., Iacucci, M.

Journal of Crohn's & Colitis.
2020 Jan 15;14(1):131-132.
https://doi.org/10.1093/ecco-jcc/jjz203.134

 Gkoutos
A one health study of the genetic relatedness of Klebsiella pneumoniae and their mobile elements in the East of England

Ludden C., Moradigaravand D.

Clinical Infectious Diseases.
2020 Jan 15;70(2):219-226.
https://doi.org/10.1093/cid/ciz174

 Moradigaravand