The Glo-BNHL trial will include three groups of children and young people, each given a new medicine (either alone or with chemotherapy). We are looking to make sure the new medicines are safe and that they work to treat the cancer. If the medicine in one group does not work for a child in the trial, then they may be able to join a different group to have another new medicine.
Experts from around the world will carefully pick the medicines most likely to be helpful to be part of the trial. If one of the new medicines seems not to be working as well as hoped then we will take it out of the trial. This will let other new medicines be added to the trial to be tested. If a medicine does seem to be working well, then it will continue in the trial to make sure it really is the most useful medicine we have.
Children from around the world will be invited to take part in the trial. We will then check on them for at least two years to look for possible side effects of the new medicine.