Recent grant funding from BCGB group leaders

Petermann: CRUK Programme Grant £1,243,213 (2019-2025) 
Investigating the effects of a de-regulated transcription machinery on replication stress in cancer.

Morris: CRUK Programme Grant £1,719,385 (2020-2024)

BRCA1 pathways in cancer predisposition and treatment

Stankovic: CRUK Programme Grant £1,376,001 (2020-2024)

RNaseH2 inactivation in cancer cells: a pathogenic mechanism and therapeutic target

Gambus: Wellcome Investigator in Science Award £1,400,000  

Replisome unloading: mechanism and importance for cell biology

Saponaro:  BBSRC grant £559,177

Interplay between RNA Pol II transcription and DNA replication

Tomlinson: Wellcome Trust Project Grant: £2,000,000 (2019 - 2023)
Explaining and exploiting the spectrum of isocitrate dehydrogenase driver mutations in different tumour types

Bonifer and Cockerill: MRC Project Grant £1,300,000 (2019-2023)
Finding therapeutic targets in FLT3-ITD AML using a systems biology approach

Petermann:  MRC Project Grant: £364,836 (2019-2022)
Characterising novel recombination pathways at DNA adducts of the environmental mutagen BDPE

Jayaraman: MRC/Newton Fund Project Grant £662,450 (2019-2022)
Inactivation of the PRH/HHEX tumour suppressor and its effects on inflammatory signalling in prostate cancer

Tomlinson: CRUK Project Grant: £500,797 (2019 - 2020)
Population-Based Early Detection of Colorectal Cancer: A Pilot Project to Evaluate the Use of Circulating Tumour DNA

Davies: CRUK Programme Foundation Award: £1,433,940 (2018-2024)
Investigating the role of PRMT5 in cancer

Tomlinson: CRUK Project Grant: £330,000 (2018 - 2023)
ACrCelerate: a colorectal cancer preclinical modelling platform a CRUK accelerator grant

Coleman: CRUK Programme: £1,315,934 (2017 - 2023)
Investigating the role of protein hydroxylation in cancer

Beggs: CRUK Programme Grant: £1,505,202 (2017 - 2022)
Building disease models to understand the molecular basis of chemoradiosensitivity and its consequences in rectal cancer (MOL-RSRC)

Morris: Wellcome Trust Programme Grant: £1,503,277 (2017 - 2022)
Regulation of SUMO in DNA double-strand break repair

Higgs: MRC Career Development Award: £1,325,000 (2017-2021)
Investigating the role of protein lysine methylation in maintaining genome stability and preventing human disease

Yau: MRC Project Grant: £325,590 (2017 - 2020)    
From single cells to populations: generalized pseudotime analysis to identify patient trajectories from cross-sectional data in cancer genomics

Badenhorst: BBSRC Project Grant: £475,607 (2017 - 2020)    
Control of genome organisation by chromatin remodelling factors

Tomlinson: ERC Programme Grant: £1,170,198 (2017 - 2019)
Why do cancers occur where they do? A genetic and evolutionary approach

Beggs: CRUK Advanced Clinician Scientist Award: £2,100,000 (2016-2021)
Building disease models to understand the molecular basis of chemoradiosensitivity and its consequences in rectal cancer (MOL-RSRC)

Cockerill: MRC Project Grant: £521,000 (2016-2019)
Epigenetic mechanisms that maintain immunological memory in CD4 T cells

Parish: MRC Project Grant: £507,000 (2016-2019)
Understanding the role of the chromatin insulator CTCF in human papillomavirus gene expression and disease progression 

Coleman: MRC Project Grant: £380,878 (2016 - 2019)
Defining a protein hydroxylase tumour suppressor pathway

Bonifer and Cockerill:  LLR Programme Grant: £1,543,859 (2015-2020)
Mechanistic insights into aberrant transcriptional programming in acute myeloid leukaemia

Morris: CRUK Programme Grant: £1,400,000 (2015-2019)
Ubiquitin processing in Cancer Development and Treatment

Müeller: Wellcome Trust Investigator Award: £950,000 (2015-2019)
The core promoter: an unexplored regulatory level of transcription during vertebrate development