DNA Replication and Repair

Replication forkThe BCBG is strongly represented by groups investigating mechanisms controlling the replication and maintenance of the genome, with a major focus on the DNA damage response and DNA repair, and genome stability.

This includes studies of the role of Ataxia Telangiectasia Mutated (ATM) protein in the response to DNA damage, and the role of ubiquitin and other proteins in the DNA replication process.

List of current principal investigators active in DNA replication and repair research

Agnieszka Gambus

Role of polyubiquitylation at the termination of eukaryotic DNA replication forks

Paloma Garcia

The role of the MybL2 (B-Myb) protein in the maintenance of genome integrity

Martin Higgs

The cellular response to DNA damage

Jo Morris

Role of Ubiquitin ligases and ubiquitination in DNA repair and genome stability

Eva Petermann

The cellular response to replication stress 

Marco Saponaro

Transcription-mediated genome instability

Tatjana Stankovic

The role of DNA damage response genes in leukaemia and lymphoma

Grant Stewart

Genome stability and the DNA Damage Response

Malcolm Taylor

Functional studies of the Ataxia Telangiectasia Mutated (ATM) protein

Andrew Turnell

Viral regulation of replication and transcription