Ageing and Frailty

Young female face on the left merging with old female face on the right.

The theme has been very successful in securing major awards in national competition, with 2 centres of excellence: the Medical Research Council Versus Arthritis Centre for Musculoskeletal Ageing Research and the Scar Free Foundation Centre for Conflict Wound Research. We also play key roles in the NIHR Birmingham Biomedical Research Centre and the NIHR Surgical Reconstruction and Microbiology Research Centre.

Janet LordTheme Lead

Professor Janet Lord

Professor of Cell Biology

View profile

Aims of our research

  • To understand the impact of ageing upon immunity and the inflammatory response;
  • To determine the mechanisms underlying loss of musculoskeletal health with age, chronic inflammatory disease and after trauma, with a focus on inflammation;
  • To determine the immune response to trauma and how this is affected by the age of the patient.
  • To understand the role of metabolism in influencing the immune response in health and disease.

Importantly, we aim not just to understand the mechanisms that underlie the loss of immune function or musculoskeletal health but to use this knowledge to develop interventions, both lifestyle and pharmacological, to improve health in older adults and trauma victims.

Our staff

Ageing and Frailty Principal Investigators
Principal InvestigatorResearch Interest
Professor Janet Lord Dysregulation of immunity in old age.
Dr Niharika Duggal Impact of ageing on the immune system and the underlying mechanisms.
Dr Paul Harrison Influence of traumatic injury and burns on the systemic inflammatory response.
Dr Thomas Jackson Cognitive disorders and how these affect both long term cognitive outcomes and the link with the ageing immune system.
Dr Simon W Jones Understanding the inflammatory and metabolic mechanisms that mediate joint and musculoskeletal pathological disorders.
Professor Claudio Mauro Interconnections between metabolic and inflammatory pathways.
Dr Myriam Chimen Understanding how immune regulatory pathways are impaired with ageing and chronic inflammatory diseases.

Our patient partnerships