Selected recent publications

Complex Obesity

Association Between Idiopathic Intracranial Hypertension and Risk of Cardiovascular Diseases in Women in the United Kingdom. Adderley NJ, Subramanian A, Nirantharakumar K, Yiangou A, Gokhale KM, Mollan SP, Sinclair AJ. JAMA Neurol. 2019 Jul 8. doi: 10.1001/jamaneurol.2019.1812. [Epub ahead of print]

Mediterranean-style diet in pregnant women with metabolic risk factors (ESTEEM): A pragmatic multicentre randomised trial. H Al Wattar B, Dodds J, Placzek A, Beresford L, Spyreli E, Moore A, Gonzalez Carreras FJ, Austin F, Murugesu N, Roseboom TJ, Bes-Rastrollo M, Hitman GA, Hooper R, Khan KS, Thangaratinam S; ESTEEM study group. PLoS Med. 2019 Jul 23;16(7):e1002857.

Energy Metabolism

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6.

Neuronatin regulates pancreatic β cell insulin content and secretion. Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. J Clin Invest. 2018 Aug 1;128(8):3369-3381.

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG Hodson DJ. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4.

Metabolic Receptor Biology

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucogon-like peptide-1 receptor distribution and dynamics. Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino A, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podwin T, Broichhagen, Hodson DJ. Nat Commun. 2020 (accepted for publication 17 Dec 2019)

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots. Sungkaworn T, Jobin ML, Burnecki K, Weron A, Lohse MJ, Calebiro D. Nature. 2017 Oct 26;550(7677):543-547.

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling. Gorvin CM, Babinsky VN, Malinauskas T, Nissen PH, Schou AJ, Hanyaloglu AC, Siebold C, Jones EY, Hannan FM, Thakker RV. Sci Signal. 2018 Feb 20;11(518). pii: eaan3714.

Cancer and Immunometabolism

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+T cells. Dimeloe S, Gubser P, Loeliger J, Frick C, Develioglu L, Fischer M, Marquardsen F, Bantug GR, Thommen D, Lecoultre Y, Zippelius A, Langenkamp A, Hess C. Sci Signal. 2019 Sep 17;12(599). pii: eaav3334.

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schill C, Hess C, Savic Prince S, Wiese M, Lardinois D, Ho PC, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A. Nat Med. 2018 Jul;24(7):994-1004. 

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring. Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J, Headland SE, Blighe K, Ruscica M, Humby F, Lewis MJ, Kamphorst JJ, Bombardieri M, Pitzalis C, Mauro C. Cell Metab. 2019 Dec 3;30(6):1055-1074.e8.

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis. Hardy RS, Fenton C, Croft AP, Naylor AJ, Begum R, Desanti G, Buckley CD, Lavery G, Cooper MS, Raza K. J Autoimmun. 2018 Aug;92:104-113.

Pituitary Tumour Research

Outcomes of patients with Nelson's syndrome after primary treatment: a multicenter study from 13 UK Pituitary centers. Fountas A, Lim ES, Drake WM, Powlson AS, Gurnell M, Martin NM, Seejore K, Murray RD, MacFarlane J, Ahluwalia R, Swords F, Ashraf M, Pal A, Chong Z, Freel M, Balafshan T, Purewal TS, Speak RG, Newell-Price J, Higham CE, Hussein Z, Baldeweg SE, Dales J, Reddy N, Levy MJ, Karavitaki N. J Clin Endocrinol Metab. 2019 Nov 18. pii: dgz200. doi: 10.1210/clinem/dgz200. [Epub ahead of print]

Outcome of Nonfunctioning Pituitary Adenomas That Regrow After Primary Treatment: A Study From Two Large UK Centers. Tampourlou M, Ntali G, Ahmed S, Arlt W, Ayuk J, Byrne JV, Chavda S, Cudlip S, Gittoes N, Grossman A, Mitchell R, O'Reilly MW, Paluzzi A, Toogood A, Wass JAH, Karavitaki N.  J Clin Endocrinol Metab. 2017 Jun 1;102(6):1889-1897.

Thyroid Tumour Research

Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake. Fletcher A, Read ML, Thornton CEM, Larner DP, Poole VL, Brookes K, Nieto HR, Alshahrani M, Thompson RJ, Lavery GG, Landa I, Fagin JA, Campbell MJ, Boelaert K, Turnell AS, Smith VE, McCabe CJ. Cancer Res. 2019 Oct 31. pii: canres.1957.2019. doi: 10.1158/0008-5472.CAN-19-1957. [Epub ahead of print]

PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. Read ML, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ. Cancer Res. 2018 Oct 15;78(20):5863-5876.

Adrenal Tumour Research

Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma. Chortis V, Bancos I, Nijman T, Gilligan LC, Taylor AE, Ronchi CL, O'Reilly MW, Schreiner J, Asia M, Riester A, Perotti P, Libé R, Quinkler M, Canu L, Paiva I, Bugalho MJ, Kastelan D, Dennedy MC, Sherlock M, Ambroziak U, Vassiliadi D, Bertherat J, Beuschlein F, Fassnacht M, Deeks JJ, Biehl M, Arlt W. J Clin Endocrinol Metab. 2019 Oct 29. [Epub ahead of print]

Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess: A Systematic Review and Meta-analysis. Elhassan YS, Alahdab F, Prete A, Delivanis DA, Khanna A, Prokop L, Murad MH, O'Reilly MW, Arlt W, Bancos I. Ann Intern Med. 2019 Jun 25. [Epub ahead of print]

Endocrine-related Cancers

Assessment of the Safety of Glucocorticoid Regimens in Combination With Abiraterone Acetate: A Randomized, Open-Label Phase 2 Study. Attard G, Merseburger AS, Arlt W, Sternberg CN, Feyerabend S, Berruti A, Joniau S, Géczi L, Lefresne F, Lahaye M, Shelby FN, Pissart G, Chua S, Jones RJ, Tombal B.  JAMA Oncol. 2019 Jun 27. [Epub ahead of print]

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL. J Med Chem. 2018 Feb 8;61(3):1031-1044.

Disorders of Steroidogenesis

Alternative pathway androgen biosynthesis and human fetal female virilization. Reisch N, Taylor AE, Nogueira EF, Asby DJ, Dhir V, Berry A, Krone N, Auchus RJ, Shackleton CHL, Hanley NA, Arlt W.  Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22294-22299.

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1. Mueller JW, Idkowiak J, Gesteira TF, Vallet C, Hardman R, van den Boom J, Dhir V, Knauer SK, Rosta E, Arlt W.  Biol Chem. 2018 Jun 22;293(25):9724-9735.

Innovative Microscopy Methodologies

Bathon K, Weigand I, Vanselow JT, Ronchi CL, Sbiera S, Schlosser A, Fassnacht M, Calebiro D. Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome. Endocrinology. 2019 Feb 1;160(2):447-459. doi: 10.1210/en.2018-00775.

Conception and Early Pregnancy

A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy. Coomarasamy A, Devall AJ, Cheed V, Harb H, Middleton LJ, Gallos ID, Williams H, Eapen AK, Roberts T, Ogwulu CC, Goranitis I, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Kriedt K, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingam N, Watkins L, Wykes C, Horne A, Jurkovic D. N Engl J Med. 2019 May 9;380(19):1815-1824.

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A. N Engl J Med. 2019 Apr 4;380(14):1316-1325. 18 citations (Web of Science, Dec 2019)

Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study. Lord J, McMullan DJ, Eberhardt RY, Rinck G, Hamilton SJ, Quinlan-Jones E, Prigmore E, Keelagher R, Best SK, Carey GK, Mellis R, Robart S, Berry IR, Chandler KE, Cilliers D, Cresswell L, Edwards SL, Gardiner C, Henderson A, Holden ST, Homfray T, Lester T, Lewis RA, Newbury-Ecob R, Prescott K, Quarrell OW, Ramsden SC, Roberts E, Tapon D, Tooley MJ, Vasudevan PC, Weber AP, Wellesley DG, Westwood P, White H, Parker M, Williams D, Jenkins L, Scott RH, Kilby MD, Chitty LS, Hurles ME, Maher ER; Prenatal Assessment of Genomes and Exomes Consortium. Lancet. 2019 Feb 23;393(10173):747-757.

Late Pregnancy - Maternal and Fetal Health

Risks of stillbirth and neonatal death with advancing gestation at term: A systematic review and meta-analysis of cohort studies of 15 million pregnancies. Muglu J, Rather H, Arroyo-Manzano D, Bhattacharya S, Balchin I, Khalil A, Thilaganathan B, Khan KS, Zamora J, Thangaratinam S. PLoS Med. 2019 Jul 2;16(7):e1002838.

Pregnancy Outcomes in Women With Transposition of the Great Arteries After an Arterial Switch Operation. Stoll VM, Drury NE, Thorne S, Selman T, Clift P, Chong H, Thompson PJ, Morris RK, Hudsmith LE. JAMA Cardiol. 2018 Nov 1;3(11):1119-1122.

Pulse oximetry screening for critical congenital heart defects. Plana MN, Zamora J, Suresh G, Fernandez-Pineda L, Thangaratinam S, Ewer AK. Cochrane Database Syst Rev. 2018 Mar 1;3:CD011912.

Global Maternal Health

Antibiotic prophylaxis in the surgical management of miscarriage in low-income countries: a cost-effectiveness analysis of the AIMS trial. Goranitis I, Lissauer DM, Coomarasamy A, Wilson A, Daniels J, Middleton L, Bishop J, Hewitt CA, Weeks AD, Mhango C, Mataya R, Ahmed I, Oladapo OT, Zamora J, Roberts TE. Lancet Glob Health. 2019 Sep;7(9):e1280-e1286.

Maternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and meta-analysis. Sobhy S, Arroyo-Manzano D, Murugesu N, Karthikeyan G, Kumar V, Kaur I, Fernandez E, Gundabattula SR, Betran AP, Khan K, Zamora J, Thangaratinam S. Lancet. 2019 May 11;393(10184):1973-1982.

A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery. Lissauer D, Wilson A, Hewitt CA, Middleton L, Bishop JRB, Daniels J, Merriel A, Weeks A, Mhango C, Mataya R, Taulo F, Ngalawesa T, Chirwa A, Mphasa C, Tambala T, Chiudzu G, Mwalwanda C, Mboma A, Qureshi R, Ahmed I, Ismail H, Oladapo OT, Mbaruku G, Chibwana J, Watts G, Simon B, Ditai J, Otim Tom C, Acam J, Ekunait J, Unzia H, Iyaku M, Makiika JJ, Zamora J, Roberts T, Goranitis I, Bar-Zeev S, Desmond N, Arulkumaran S, Bhutta ZA, Gulmezoglu AM, Coomarasamy A. N Engl J Med. 2019 Mar 14;380(11):1012-1021.

Dynamic responses of the adrenal steroidogenic regulatory network. Spiga F, Zavala E, Walker JJ, Zhao Z, Terry JR, Lightman SL. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6466-E6474.

An optimal strategy for epilepsy surgery: Disruption of the rich-club? Lopes MA, Richardson MP, Abela E, Rummel C, Schindler K, Goodfellow M, Terry JR PLoS Comput Biol. 2017 Aug 17;13(8):e1005637.

Background EEG Connectivity Captures the Time-Course of Epileptogenesis in a Mouse Model of Epilepsy. Słowiński P, Sheybani L, Michel CM, Richardson MP, Quairiaux C, Terry JR*, Goodfellow M*. eNeuro. 2019 6(4):1-13. pii: ENEURO.0059-19.2019.

Revealing epilepsy type using a computational analysis of interictal EEG. Lopes MA, Perani S, Yaakub SN, Richardson MP, Goodfellow M, Terry JR. Sci Rep. 2019 Jul 15;9(1):10169.

Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish. Davis SPX, Kumar S, Alexandrov Y, Bhargava A, da Silva Xavier G, Rutter GA, Frankel P, Sahai E, Flaxman S, French PMW, McGinty J. J Biophotonics. 2019 Aug 6:e201900128. doi: 10.1002/jbio.201900128. [Epub ahead of print]

The role that choice of model plays in predictions for epilepsy surgery. Junges L, Lopes MA, Terry JR*, Goodfellow M*. Sci Rep. 2019 May 14;9(1):7351.

Evolving dynamic networks: An underlying mechanism of drug resistance in epilepsy? Woldman W, Cook MJ, Terry JR. Epilepsy Behav. 2019 May;94:264-268.

A bioinformatics workflow to decipher transcriptomic data from vitamin D studies. Muñoz García A, Eijssen LM, Kutmon M, Sarathy C, Cengo A, Hewison M, Evelo CT, Lenz M, Coort SL. J Steroid Biochem Mol Biol. 2019 May;189:28-35.

The Role of Excitability and Network Structure in the Emergence of Focal and Generalized Seizures, Lopes M, Junges L, Woldman W, Goodfellow M and Terry J Front. Neurol., 11 February 2020

Statistical testing approach for fractional anomalous diffusion classification. Weron A, Janczura J, Boryczka E, Sungkaworn T, Calebiro D. Phys Rev E. 2019 Apr;99(4-1):042149. doi: 10.1103/PhysRevE.99.042149.