Dr Pu Xia PhD

Dr Pu Xia

School of Biosciences
Assistant Professor

Dr Pu Xia is an ecotoxicologist interested in understanding and predicting the molecular mechanisms underlying the toxicity of chemicals. His research focuses on the development and application of cutting-edge system toxicology approaches, including multi-omics, artificial intelligence, and adverse outcome pathway networks, to facilitate high-throughput screening and accurate prediction of chemical toxicity. Dr Pu Xia's pursuits are fundamentally oriented towards advancing the next-generation chemical risk assessment.


PhD, Nanjing University

BSc, Nanjing University


Dr Pu Xia obtained his PhD degree from Nanjing University in 2018. He subsequently started his postdoc research on toxicogenomics at the University of Ottawa and Environment and Climate Change Canada from 2019 to 2022, then at the Toxicology Centre, University of Saskatchewan from 2022 to 2023. In Jun 2023, He took up the post of Assistant Professor in Precision Toxicology at the University of Birmingham. He is now a member of the Centre for Environmental Research and Justice (CERJ).


Dr Xia is the Module Lead for New approach methodologies for regulatory toxicology, MASc Environmental Toxicology with Law.


  • High-throughput multi-omics for screening toxic chemicals
  • Adverse outcome pathway network-based toxicogenomic assessment of environmental chemicals
  • AI-based system toxicology models for chemical toxicity prediction
  • Mixture Toxicogenomics


  1. Xia P, Ying P, Fang W, Tian M, Shen Y, Ma C, Crump D, O'Brien JM, Shi W, Zhang X. (2021) Cross-Model Comparison of Transcriptomic Dose-Response of Short-Chain Chlorinated Paraffins. Environ. Sci. Technol. 55(12): 8149-8158.
  2. Zahaby Y#, Xia P#, Crump D, Provencher J, Thomas P, Pauli B, Braune B, Franckowiak R, Gendron M, Savard G, Sarma S, Mallory M, and O'Brien JM. (2021) ToxChip PCR Arrays for Two Arctic-Breeding Seabirds: Applications for Regional Environmental Assessments. Environ. Sci. Technol. 55(11): 7521-7530.
  3. Xia P, Crump D, Chiu S, Chan HM, O'Brien JM. (2020) Toxicogenomic Assessment of Complex Chemical Signatures in Double-Crested Cormorant Embryos from Variably Contaminated Great Lakes Sites. Environ. Sci. Technol. 54, (12), 7504-7512.
  4. Wang P#, Xia P#, Yang J, Wang Z, Peng Y, Shi W, Villeneuve DL, Yu H, Zhang X. (2018) A Reduced Transcriptome Approach to Assess Environmental Toxicants Using Zebrafish Embryo Test. Environ. Sci. Technol. 52, (2), 821-830. (# co-1st)
  5. Xia P, Zhang X, Zhang H, Wang P, Tian M, Yu H. (2017) Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells. Environ. Sci. Technol. 51, (16), 9318-9326.
  6. Xia P, Zhang X, Xie Y, Guan M, Villeneuve DL, Yu H. (2016) Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening. Environ. Sci. Technol. 50, (19), 10682-10692. (Front Cover, ES&T 2016 Best Paper Award, ACS Editor’ Choice)
  7. Peng Y#, Xia P#, Zhang J, Villeneuve DL, Zhang J, Wang Z, Wei S, YuH, Zhang X. (2016) Toxicogenomic Assessment of 6-OH-BDE47-Induced Developmental Toxicity in Chicken Embryos. Environ. Sci. Technol. 50, (22), 12493-12503. (#co-1st)
  8. Xia P, Zhang H, Peng Y, Shi W, Zhang X. (2020) Pathway-based assessment of single chemicals and mixtures by a high-throughput transcriptomics approach. Environment International. DOI: 10.1016/j.envint.2019.105455.
  9. Saquib Q#, Xia P#, Siddiqui MA, Zhang J, Xie Y, Faisal M, Ansari SM, Alwathnani HA, Alatar AA, Al Khedhairy AA, Zhang X. (2020) Highthroughput transcriptomics: An insight on the pathways affected in HepG2 cells exposed to nickel oxide nanoparticles. Chemosphere. DOI: 10.1016/j.chemosphere. (# co-1st)
  10. Tian M#, Xia P#, Gou X, Yan L, Yu H, Zhang X. (2022) CRISPR screen identified that UGT1A9 was required for bisphenols-induced mitochondria dyshomeostasis. Environmental Research, 205, 112427. (# co-1st)
  11. Fang W,Peng Y,Yan L, Xia P, Zhang X. (2020) A Tiered Approach for Screening and Assessment of Environmental Mixtures by Omics and In Vitro Assays. Environ. Sci. Technol. 54, (12), 7430-7439.
  12. Zhang X, Xia P, Wang P, Yang J, Baird DJ. (2018) Omics Advances in Ecotoxicology. Environ. Sci. Technol. 52, (7), 3842-3851. (ES&T Invited Feature Article)
  13. Tian M, Xia P, Yan L, Gou X, Giesy J, Dai J, Yu H, Zhang X. (2022) Toxicological Mechanism of Individual Susceptibility to Formaldehyde-Induced Respiratory Effects. Environ. Sci. Technol. 56(10): 6511-6524. (Selected as Supplementary Cover Paper)
  14. Guo J, Shen Y, Zhang X, Lin D, Xia P, Song M, Yan L, Zhong W, Gou X, Wang C, Wei S, Yu H, Shi W. (2022) Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River. Environ. Sci. Technol. 56(12): 7840–7852.

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