Professor Michael John Hannon MA (Cantab.), PhD

Professor Michael Hannon

School of Chemistry
Chair of Chemical Biology
Director of the EPSRC Research & Training Centre in Physical Sciences for Health

Contact details

Address
Research and Training Centre in Physical Sciences for Health
School of Chemistry
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Mike Hannon holds the Chair of Chemical Biology at the University of Birmingham and is the Director of the EPSRC Research and Training Centre in Physical Sciences for Health. He is a member of the Board of Trustees of the Institute of Advanced Study at TU Munich (https://www.ias.tum.de/en/institute-for-advanced-study) and the Scientific Advisory Board of Zukunftskolleg at University of Konstanz (https://www.uni-konstanz.de/zukunftskolleg/)

Mike's research lies at the interface between chemistry and the life sciences and is focused on metal complexes in biology and medicine as both imaging agents and therapeutics. He has expertise in synthetic chemistry (organic, supramolecular, nanoscale) and in applying biophysical methods to recognition of different DNA structures. In particular his work on the non-covalent recognitionof DNA Y-shaped junctions has transformed the field of study and prompted a sudden and growing international activity in exploring the use of metallo-supramolecular structures in DNA recognition and as anti-cancer drugs. 

Mike is the immediate post President of The Society of Biological Inorganic Chemistry (SBIC), the international learned society. He chaired the prestigious Gordon Research Conference 'Metals in Medicine' in 2014 and was the chair of the 14th European conference on Biological Inorganic Chemistry which he hosted at the University of Birmingham in 2018.

Mike was Director of Birmingham's Institute of Advanced Studies from 2015-19, (https://www.birmingham.ac.uk/research/activity/ias/index.aspx) and co-organiser of the Intercontinental Academia ‘Laws Rigidity and Dynamics’ jointly with NTU Singapore in 2018-19.   (https://www.icalaws.com)

Qualifications

  • Ph.D. Chemistry - University of Cambridge, 1994
  • B.A. Natural Sciences (first class) - University of Cambridge, 1990
  • M.A. (Cantab) - University of Cambridge, 1994

Biography

Mike Hannon qualified with a first class B.A. (Hons) in Natural Sciences from the University of Cambridge in 1990. He remained at Cambridge (90-93) to study for a PhD in Inorganic Chemistry with Professor Ed Constable and then was awarded a Royal Society ESEP Fellowship to work with Nobel laureate Professor Jean-Marie Lehn in Strasbourg (93-94). He returned to the UK in 1994 to take up a lectureship at the University of Warwick. He received two awards for teaching excellence, and was promoted to Professorship in 2005. He was appointed to the Chair of Chemical Biology at the University of Birmingham in Autumn 2005 and became Director of the PSIBS Biomedical Imaging Centre in 2008. 

Much of Mike’s research output appears in top chemistry journal Angewandte Chemie, and in 2011 the journal published an author profile about him, so you can learn more about his favourite football team and what he and his research team would do if he won the lottery.  

Teaching

Teaching Programmes

Postgraduate supervision

Opportunities are available for doctoral research students in the following areas:

  • Imaging Chemistry for Biology and Medicine
  • Molecular Probe Design
  • Bioinorganic Chemistry
  • Metal-based Drugs
  • DNA Recognition
  • Biological Chemistry and Chemical Biology
  • Supramolecular Chemistry
  • Physical Sciences of Imaging in the Biomedical Sciences

If you are interesting in studying any of these subject areas, please contact Professor Hannon or his PA on the contact details above.

For more information about the Sci-Phy-4-Health programme, please contact the Centre Administrator either via email: sci-phy@contacts.bham.ac.uk or on telephone number +44 (0) 121 414 8808.

Research

A perfect fit for cancer treatment

Publications

Iridium nanoparticles for multichannel luminescence lifetime imaging, mapping localization in live cancer cells, S.M. King, S. Claire, R.I. Teixeira, A.N. Dosumu, A.J. Carrod, H. Dehghani, M.J. Hannon, A.D. Ward, R. Bicknell, S.W. Botchway, N.J. Hodges, and Z. Pikramenou  J. Am. Chem.Soc., 2018, 140, 10242−10249. DOI:10.1021/jacs.8b05105

Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo, L. Cardo, I. Nawroth, P.J. Cail, J.A. McKeating and M.J. Hannon, Scientific Reports, 2018, 8, Article number: 13342. DOI:10.1038/s41598-018-31513-3

Non-covalent Metallo-Drugs: Using shape to target DNA and RNA junctions and other nucleic acid structures, L. Cardo and M. J. Hannon, Metals in Life Sciences, Volume 18, Chapter 11, 2018, 303-324 (Ed. R. Sigel, H. Sigel, A. Sigel), De Gruyter

Iron (II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication, J. Malina, M. J. Hannon, V. Brabec, Scientific Reports, 2016, 6, Article Number: 29674  

Iron (II) Supramolecular Helicates Condense Plasmid DNA and Inhibit Vital DNA-related Enzymatic Activities, J. Malina, M. J. Hannon, V. Brabec, Chem. Eur. J., 2015, 21, 11189–95

Accessible synthetic probes to stain actin inside platelets and megakaryocytes employing Lifeact peptide, L. Cardo, S. G. Thomas, A. Mazharian, Z. Pikramenou, J.Z. Rappoport, M.J. Hannon and S.P. Watson ChemBioChem, 2015, 16, 1680 – 1688

Platelet actin nodules are podosome-like structures dependent on Wiskott - Aldrich syndrome protein and Arp2/3 complex, N.S. Poulter, A. Davies, A.Y.  Pollitt, M. Dessislava, G.B. Nash, M.J. Hannon, Z. Pikramenou, J.Z.  Rappoport, J.H. Hartwig, D.M. Owen, A.J. Thrasher, S.P. Watson, S.G. Thomas, Nature Communications, 2015, 6, 7254.

Metal interactions with nucleic acids, M.J.  Hannon and J Reedijk, Dalton Trans., 2015, 44, 3503-4

Recognition of DNA bulges by dinuclear iron (II) metallosupramolecular helicates, J. Malina, M.J. Hannon, V. Brabec, FEBS J. 2014, 281, 987–997.  DOI: 10.1111/febs.12696.

Investigating the Interactions of Metal Complexes with G-Quadruplex forming DNA, H. Pritchard, M. J. Hannon, J. Biol. Inorg. Chem., 2014, 19, S363

Supramolecular recognition of non-canonical DNA structures in vitro and in cells, M. Hannon, J. Biol. Inorg. Chem., 2014, 19, S118

Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction, S. Phongtongpasuk, S. Paulus, J. Schnabl, R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger, Angew. Chem. Intl Ed, 2013, 52, 11513-11516.  DOI: 10.1002/anie.201305079

Highlighted on the journal front cover

DNA interaction of CuII, NiII and ZnII functionalized Salphen complexes: studies by linear dichroism, gel electrophoresis and PCR, A. Terenzi, C. Ducani, L. Male, G. Barone and M.J. Hannon, Dalton Trans., 2013, 42, 11220-6.

DNA Binding Studies and Cytotoxicity of a Dinuclear PtII Diazapyrenium-Based Metallo-supramolecular Rectangular Box, A. Terenzi, C. Ducani, V. Blanco, L. Zerzankova, A.F. Westendorf, C. Peinador, J.M. Quintela, P.J. Bednarski, G. Barone and M.J. Hannon, Chem Eur J., 2012, 18, 10983-10990   DOI:org/10.1002/chem.201201519

A Potent Ruthenium (II) Antitumor Complex Bearing a Lipophilic Levonorgestrel Group, J. Ruiz, V. Rodríguez, N. Cutillas, A. Espinosa, M.J. Hannon, Inorg. Chem., 2011, 50,9164-9171, DOI : 10.1021/ic201388n   

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity, L. Cardo, V. Sadovnikova, S. Phongtongpasuk, N.J. Hodges, M.J. Hannon, Chem. Commun., 2011, 47, 6575 – 6577   

Novel C, N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant, J. Ruiz, V. Rodriguez, N. Cutillas, A. Espinosa, M.J. Hannon, J. Inorg. Biochem.2011, 105, 525-531, DOI: 10.1016/j.jinorgbio.2010.12.005

Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro, C. Ducani, A. Leczkowska, N.J. Hodges, M.J. Hannon, Angew. Chem. Intl. Ed., 2010, 49, 8942-8945, DOI: 10.1002/anie.201004471

Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix, C. Sanchez-Cano, M. Huxley, C. Ducani, A.E. Hamad, M.J. Browning, C. Navarro-Ranninger, A.G. Quiroga, A. Rodger, M. J. Hannon, Dalton Trans., 2010, 39, 11365-11374, DOI: 10.1039/C0DT00839G                                     

An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug, M. Huxley, C. Sanchez-Cano, M.J. Browning, C. Navarro-Ranninger, A.G. Quiroga, A. Rodger, M. J. Hannon, Dalton Trans., 2010, 39, 11353-11364,DOI: 10.1039/C0DT00838A

Towards functionalizable DNA frames: Self-assembly of two-component 3D DNA arrays through induction of DNA three-way junction branch points by supramolecular cylinder,D.R. Boer, J. M. C. A. Kerckhoffs, Y. Parajo, M. Pascu, I. Usón, P. Lincoln, M.J. Hannon, M. Coll , Angew. Chem. Intl. Ed., 2010, 49, 2336-2339, DOI: 10.1002/anie.200906742

Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs, A.J. Pope, C. Bruce, B. Kysela, M.J. Hannon, Dalton Trans., 2010, 39, 2772-2774, DOI: 10.1039/b927129p

Electron Capture Dissociation Mass Spectrometry of Metallo-Supramolecular Complexes, M.A. Kaczorowska, A.C.G. Hotze, M.J. Hannon, H.J. Cooper, J. Am. Soc. Mass. Spectom., 2009, 21, 300-309, DOI:10.1016%2Fj.jasms.2009.10.018

Novel and emerging approaches for the delivery of metallo-drugs, C. Sanchez-Cano and M.J. Hannon, Dalton Trans., 2009, 48, 10702-10711. DOI:10.1039/b912708

Cytotoxicity, cellular localisation and biomolecular interaction of non- covalent metallo-intercalators with appended sex hormone steroid vectors, C. Sanchez-Cano, M.J. Hannon, Dalton Trans., 2009, 48, 10765-10773. DOI:10.1039/b912711a

Preparation of novel banana-shaped triple helical liquid crystals by metal coordination, P. Iqbal, M. Mayanditheuar, L. Childs, M.J. Hannon, N. Spencer, P.R. Ashton, J.A. Preece, Materials, 2009, 2, 146-168. DOI: org/10.3390/ma2010146

Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(ii) triple helicates, Y. Parajo, J. Malina, I. Meistermann,  G.J. Clarkson, M. Pascu, A. Rodger, M.J. Hannon, Per Lincoln, Dalton Trans., 2009, 25, 4868-4874. DOI: 10.1039/b822039e

Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds? E. Corral, A.C. Hotze, H. den Dulk, A. Leczkowska, A. Rodger, M.J. Hannon. J. Reedijk, J. Biol. Inorg. Chem., 2009, 14, 439-448.DOI 10.1007/s00775-008-0460-x   

Antimicrobial activity of an iron triple helicate., A.D. Richards, A. Rodger, M.J. Hannon, A. Bolhuis, Int. J. Antimicrob. Agents, 2009, 33, 469-72.  DOI10.1016/j.ijantimicag.2008.10.031

Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides, L. Cardo, M.J. Hannon, Inorg. Chim. Acta. 2009, 362, 784-792. DOI 10.1016/j.ica.2008.02.050   

A supramolecular triple-stranded iron cylinder with unprecedented DNA binding action is a potent cytostatic and apoptotic agent without exhibiting genotoxicity, A.C.G. Hotze, N.J. Hodges, R.E. Hayden, C. Sanchez-Cano, C. Paines, N. Male, M.-K. Tse, C.M. Bunce, J.K. Chipman, M.J. Hannon, Chemistry & Biology, 2008, 15, 1258-1267. DOI 10.1016/j.chembiol.2008.10.016                                                         

DNA binding and bending by dinuclear complexes comprising ruthenium polypyridyl centres linked by a bis(pyridylimine) ligand, U. McDonnell, M. R. Hicks, M. J. Hannon, A. Rodger, J Inorg Biochem., 2008, 102, 2052-2059. DOI 10.1016/j.jinorgbio.2008.06.006

Interactions of Dinuclear Ruthenium (II) Supramolecular Cylinders with DNA. Sequence-specific Binding, Unwinding and Photocleavage, J. Malina, M. J. Hannon, and V. Brabec, Chem. Eur J., 2008, 14, 10408-10414. DOI 10.1002/chem.200801364                                               

DNA binding of dinuclear iron (II) metallosupramolecular cylinders. DNA unwinding and sequence preference, J. Malina, M. J. Hannon, V. Brabec, Nucleic Acids Res., 2008, 36, 3630-3638. DOI 10.1093/nar/gkn244

Effect of adenine moiety on DNA binding property of copper (II)-terpyridine complexes, Q. Jiang, Z.Y. Wu, Y.M. Zhang, A.C.G. Hotze, M.J. Hannon, Z.J. Guo, Dalton Trans., 2008, 3054-60. DOI: 10.1039/b719010g

New organogelators based on cyclotriveratrylene platforms bearing 2-dimethylacetal-5-carbonylpyridine fragments, D. Bardelang, F. Camerel, R. Ziessel , M. Schmutz, M. J. Hannon, J. Mater. Chem, 2008, 18, 489-494. DOI 10.1039/b712413a

Synthesis and Cytotoxicity of Dinuclear Complexes containing Ruthenium (II) Bipyridyl units linked by a bis-pyridylimine ligand, U. McDonnell, J.M.C.A. Kerchoffs, R.P.M. Castineiras, M.R. Hicks, A.C.G. Hotze, M.J. Hannon, A. Rodger, Dalton Trans., 2008, 667-675. DOI 10.1039/b711080d

Metal-based Anti-cancer Drugs; from a past anchored in Platinum Chemistry to a Post-genomic future of diverse Chemistry and Biology, M.J. Hannon, Pure and Applied Chemistry, 2007, 79, 2243-2261. DOI 10.1351/pac200779122243

Influence of surface shape on DNA binding of bimetallo helicates, J. C. Peberdy, J. Malina, S. Khalid, M. J. Hannon, A. Rodger, J. Inorg. Biochem. 2007, 101, 1937-1945 (special issue in Memory of Edward I. Stiefel). 

Sodium Chains as Core Nanowires for Gelation of Organic Solvents from a Fuctionalized Nicotinic Acid and its Sodium Salt, D. Bardelang, F. Camerel, A. C. G. Hotze, B. Kariuki, B. Paik, M. Schmutz, R. Ziessel, M. J. Hannon, Chem. Eur. J., 2007, 13, 9277-9285. DOI 10.1002/chem.200700660

Supramolecular Circular Helicates Formed by Destabilisation of Supramolecular Dimers.

J. Hamblin, F. Tuna, S. Bunce, L. J. Childs, A. Jackson, W. Errington, N. W. Alcock, H. Nierengarten, A. Van Dorselaer, E. Leize-Wagner, M. J. Hannon, Chem. Eur. J., 2007, 13, 9286-9296. DOI 10.1002/chem.200700848

Design and Non-Covalent DNA bonding of Platinum (II) Metallacalix[4]arenes.

M. A. Galindo, D. Olea, M A Romero, J. Gomez, P. del Castillo, M. J. Hannon, A. Rodger, F. Zamora, J. A. R. Navarro, Chem. Eur. J., 2007, 13, 5075-5081.DOI 10.1002/chem.200601581

Featured on the journal front cover DOI 10.1002/chem.200790062

Dinuclear Ruthenium (II) triple-stranded helicates: luminiscent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines, G. I. Pascu, A. C. G. Hotze, C. Sanchez Cano, B. M. Kariuki, M. J. Hannon, Angew. Chem., Intl. Ed., 2007, 46, 4374-4378. DOI 10.1002/anie.200700656

DNA Three-Way Junction with a Dinuclear Iron (II) Supramolecular Helicate at the Center: A NMR structural Study, L. Cerasino, M. J. Hannon, E. Sletten, Inorg. Chem., 2007, 46, 6245-6251. DOI 10.1021/ic062415c

Recognition of DNA Three-Way Junctions by Metallosupramolecular Cylinders: Gel Electrophoresis Studies, J. Malina, M. J. Hannon, V. Brabec, Chem. Eur. J., 2007, 13, 3871-3877. DOI 10.1002/chem.200700159

Enantiomeric resolution of supramolecular helicates with different surface topographies, J. M. C. A. Kerckhoffs, J. C. Peberdy, I. Meistermann, L J. Childs, C. J. Isaac, C.  R. Pearmund, V. Reudegger, S. Khalid, N. W. Alcock, M. J. Hannon and A. Rodger, Dalton Trans., 2007, 734-742. DOI 10.1039/b614093a

Supramolecular DNA recognition, M.J. Hannon, Chem. Soc. Rev., 2007, 36, 280-295. DOI 10.1039/b606046n

Shape effects on the activity of synthetic major-groove binding ligands, S. Khalid, M.J. Hannon, A. Rodger, P.M. Rodger, Journal of Molecular Graphics and Modelling, 2007, 794-800. DOI 10.1016/j.jmgm.2006.07.004

Dinuclear Double Stranded Metallo-supramolecular Ruthenium Complexes; Potential Anticancer Drugs, A.C.G. Hotze, B.M. Kariuki and M.J. Hannon, Angew. Chem., Intl. Ed., 2006, 45, 4839-4842. DOI 10.1002/anie.200601351

Far-Red luminescent ruthenium pyridylimine complexes; building blocks for multinuclear arrays, A.C.G. Hotze, J.A. Faiz, N. Mourtzis, G.I. Pascu, P.R.A. Webber, G. J. Clarkson, K. Yannakopoulou, Z. Pikramenou and M.J. Hannon, Dalton. Trans., 2006, 24, 3025 -3034. DOI 10.1039/b518027a

An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery, M.J. Hannon, P.S. Green, D.M. Fisher, P.J. Derrick, J.L. Beck, S.J. Watt, M.M. Sheil, P.R. Barker, N.W. Alcock, R.J. Price, K.J. Sanders, R. Pither, J. Davis and A. Rodger, Chem. Eur. J., 2006, 12, 8000-8013. DOI 10.1002/chem.200501012

A DNA-binding copper(I) metallo-supramolecular cylinder that can act as an artificial nuclease, L.J. Childs, J. Malina, B.E. Rolfsnes, M. Pascu, M.J. Prieto, M.J. Broome, P.M. Rodger, E. Sletten, V. Moreno, A. Rodger and M.J. Hannon, Chem.  Eur. J., 2006, 12, 4919-4927. DOI 10.1002/chem.200600060

Aggregation of imine - based metallo-supramolecular architectures through π-π interactions, M. Pascu, G.J. Clarkson, B. M. Kariuki and M. J. Hannon, Dalton Trans. 2006, 22, 2635-2642. DOI 10.1039/b517643c

Simulations of DNA coiling around a synthetic supramolecular cylinder that binds in the DNA major groove, S. Khalid, M.J. Hannon, A. Rodger and P.M. Rodger, Chem. Eur. J., 2006, 12, 3493-3506. DOI 10.1002/chem.200501168

Molecular recognition of a three-way DNA junction by a metallo-supramolecular helicate, A. Oleksy, A.G. Blanco, R. Boer, I. Usón, J. Aymami, A. Rodger, M.J. Hannon and  M. Coll,  Angew. Chem., Intl. Ed., 2006, 45, 1227-1231. DOI 10.1002/anie.200503822                                     

Featured on the journal front cover DOI 10.1002/anie.200690026

Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder, C. Uerpmann, J. Malina, M. Pascu, G.J. Clarkson, V. Moreno, A. Rodger, A. Grandas and M.J. Hannon, Chem., Eur. J., 2005, 11, 1750-6.  DOI 10.1002/chem.200401054                        

Readily prepared metallo-supramolecular triple-helicates designed to exhibit spin-crossover behaviour, F. Tuna, M.R. Lees, G.J. Clarkson and M.J. Hannon, Chem. Eur. J., 2004, 10, 5737-5750. DOI 10.1002/chem.200400518

Channel structures in a simple inorganic salt; An open framework formed through structural integration of distinct sodium acetate and sodium perchlorate domains, A. Lavalette, G. Lawrance, N.W. Alcock and M.J. Hannon, Eur. J. Inorg. Chem., 2004, 3981-3983. DOI 10.1002/ejic.200400365

Using non-covalent intra-strand and inter-strand interactions to prescribe helix formation within a metallo-supramolecular system, L.J. Childs, M. Pascu, A.J. Clarke, N.W. Alcock and M.J. Hannon, Chem., Eur. J., 2004, 10, 4291-4300. DOI 10.1002/chem.200400169                     

Binding Sites on the outside of Metallo-supramolecular architectures; engineering coordination polymers from discrete architectures, M. Pascu, F. Tuna, E. Kolodziejczyk, G.I. Pascu, G. Clarkson and M.J. Hannon, Dalton Trans., 2004, 1546-55. DOI 10.1039/b403749a

Helices and Helicates, L.J. Childs and M.J. Hannon, Supramolecular Chem, 2004, 16, 7-22.  DOI 10.1081/1061027031001632286                  

 

Supramolecular cylinders that recognise the DNA major groove and induce dramatic intramolecular coiling, L.J. Childs, J. Malina, J.M.C.A. Kerckhoffs, A. Rodger and M.J. Hannon, Chem. Listy., 2004, 98, s105-6

Aggregation of metallo-supramolecular architectures by metallo-assembled hydrogen bonding sites, A. Lavalette, F. Tuna, J. Hamblin, A. Jackson, G. Clarkson, N.W. Alcock and M.J. Hannon, Chem. Commun., 2003, 2666-2667. DOI 10.1039/b308963k                             

Metallo-supramolecular libaries: triangles, polymers and double-helicates assembled by copper(I) coordination to directly linked bis-pyridylimine ligands, F. Tuna, J. Hamblin, A. Jackson, G. Clarkson, N.W. Alcock and M.J. Hannon, Dalton Trans., 2003, 2141-2148. DOI 10.1039/b211005a

The effect of phenyl substituents on supramolecular assemblies containing directly linked bis-pyridylimine ligands: synthesis and structural characterisation of mononuclear nickel (II) and dinuclear silver(I) and cobalt (III) complexes of (2-pyridyl)phenylketazine, F. Tuna, G. Clarkson, N.W. Alcock and M.J. Hannon, Dalton Trans., 2003, 2149-55.                        DOI 10.1039/b211006g

Supramolecular Chemistry: The Future, M.J. Hannon, Supramolecular Chem, 2003, 15, 475. DOI 10.1080/10610270310001632386                                                

Flow oriented linear dichroism to probe protein orientation in membrane environments, A. Rodger, J. Rajendra, R. Mortimer, T. Andrews, J.B. Hirst, A.T.B. Gilbert, R. Marrington, D. Halsall, T. Dafforn, M. Ardhammar, B. Norden, C.A. Woolhead, C. Robinson, T. Pinheiro, J. Kazlauskaite, M. Seymour, N. Perez and M.J. Hannon, in Biophysical Chemistry: Membranes and Proteins, Templer, R.H. and Leatherbarrow, R. (eds) The Royal Society of Chemistry, Cambridge, 2002, pp 3-19.

Interfacing supramolecular and macromolecular chemistry: Metallo-supramolecular triple-helicates incorporated into polymer networks, A. Lavalette, J. Hamblin, A. Marsh, D.M. Haddleton and M.J. Hannon, Chem. Commun., 2002, 3040-3041. DOI 10.1039/b210019c

Assembly on a nanoscale chiral ball through supramolecular aggregation of bowl-shaped triangular helicates, L.J. Childs, N.W. Alcock and M.J. Hannon, Angew. Chem., Intl. Ed., 2002, 41, 4244-4247. DOI 10.1002/1521-3773(20021115)41:22<4244::AID-ANIE4244>3.0.CO;2-5                                                                            

Helical (Isotactic) and Syndiotactic Silver(I) Metallo-Supramolecular Coordination Polymers assembled from a readily-prepared Bis-Pyridylimine Ligand containing a 1,5-Naphthalene Spacer, F. Tuna, J. Hamblin, G. Clarkson, W. Errington, N.W. Alcock and M. J. Hannon, Chem., Eur. J., 2002, 8, 4957-4964. DOI 10.1002/1521-3765(20021104)8:21<4957::AID-CHEM4957>3.0.CO;2-N                                                                                                        

Groovy DNA recognition; new agents for gene regulation? M.J. Hannon and A. Rodger, Pharmaceutical Visions, 2002, Autumn issue, 14-16.

Anti-tumour platinum acylthiourea complexes and their interactions with DNA, A. Rodger, K.K. Patel, K.J. Sanders, M. Datt, C. Sacht and M.J. Hannon, J. Chem. Soc., Dalton Trans., 2002, 3656-3663. DOI 10.1039/b205056k

Flow oriented linear dichroism to probe protein orientation in membrane environments, A. Rodger, J. Rajendra, R. Marrington, M. Ardhammar, B. Norden, J.D. Hirst, A.T.B. Gilbert, T.R. Dafforn, D.J. Halsall, C.A. Woolhead, C. Robinson, T.J.T. Pinheiro, J. Kazlauskaite, M. Seymour, N. Perez and M.J. Hannon, Phys. Chem. Chem. Phys., 2002, 4051-4057.                DOI 10.1039/b205080n

Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers, I. Meistermann, V. Moreno, M.J. Prieto, E. Moldrheim, E. Sletten, S. Khalid, P.M. Rodger, J.C. Peberdy, C.J. Isaac, A. Rodger and M.J. Hannon, Proc. Natl. Acad. Sci., USA., 2002, 99, 5069-5074. DOI 10.1073/pnas.062634499

Triple helicates and planar dimers arising from silver(I) coordination to directly linked bis-pyridylimine ligands, J. Hamblin, A. Jackson, N.W. Alcock and M. J. Hannon, J. Chem. Soc., Dalton Trans., 2002, 1635-1641. DOI: 10.1039/b110137b

Interaction between a DNA oligonucleotide and dinuclear iron (II) supramolecular cylinder; A NMR and molecular dynamics study, E. Molderheim, I. Meistermann, A. Rodger, M.J. Hannon and E. Sletten, J. Biol. Inorg. Chem., 2002, 7, 770-780.            DOI 10.1007/s00775-002-0354-2

Aryl substituted ruthenium bisterpyridine complexes: Intercalation and groove binding with DNA, K.K. Patel, E.A. Plummer, M. Darwish, A. Rodger and M.J. Hannon, J. Inorg. Biochem., 2002, 91 (ICBIC-10 special issue) 220-229. DOI 10.1016/S0162-0134(01)00423-8                                

Directed one-pot syntheses of enantiopure dinuclear silver(I) and copper(I) metallo-supramolecular double helicates, J. Hamblin, L.J. Childs, N.W. Alcock and M.J. Hannon, J. Chem. Soc., Dalton Trans., 2002, 164-169. DOI: 10.1039/b106987j

Competing supramolecular interactions give a new twist to terpyridyl chemistry; anion and solvent induced formation of spiral arrays in silver(I) complexes of a simple terpyridine, M.J. Hannon, C.L. Painting, E.A. Plummer, L.J. Childs and N.W. Alcock, Chem., Eur. J., 2002, 8, 2225-2238. DOI 10.1002/1521-3765(20020517)8:10<2225::AID-CHEM2225>3.0.CO;2-X

Immobilisation of π-assembled metallo-supramolecular arrays in thin films; from crystal engineered structures to processable materials, H. Krass, E.A. Plummer, J.M. Haider, P.R. Barker, N.W. Alcock, Z. Pikramenou, M.J. Hannon and D.G. Kurth, Angew. Chem., Intl. Ed., 2001, 40, 3862-3865. DOI 10.1002/1521-3773(20011015)40:20<3862::AID-ANIE3862>3.0.CO;2-N                                                                                                                        

Paper: a cheap yet effective chiral stationary phase for chromatographic resolution of metallo-supramolecular helicates, M.J. Hannon, I. Meistermann, C.J. Isaac, C. Blomme, J.R. Aldrich-Wright and A. Rodger, Chem. Commun., 2001, 1078-79. DOI: 10.1039/b101970h

The design and synthesis of estrogen-derived steroids as cellular delivery vehicles for metal centres in estrogen receptor-positive cells, A. Jackson, J. Davis, R.J. Pither, A. Rodger and M.J. Hannon, Inorg. Chem., 2001, 40, 3964-3973.                     DOI: 10.1021/ic010152a

A dendritic structure containing a designed cleft which controls ligand coordination behaviour in an analogous way to proteins, M.J. Hannon, P.C. Mayers and P.C. Taylor, Angew. Chem., Intl. Ed., 2001, 40, 1081-1084. DOI: 10.1002/1521-3773%2820010316%2940:6%3C1081::AID-ANIE10810%3E3.0.CO;2-#                                      

Assembly of nano-scale circular supramolecular arrays through π-π aggregation of arc-shaped helicate units, L.J. Childs, N.W. Alcock and M.J. Hannon, Angew. Chem., Intl. Ed., 2001, 40, 1079-1081. DOI 10.1002/1521-3773(20010316)40:6<1079::AID-ANIE10790>3.0.CO;2-Q                                                                              

Intramolecular DNA coiling mediated by a metallo supramolecular cylinder, M.J. Hannon, V. Moreno, M.J. Prieto, E. Molderheim, E. Sletten, I. Meistermann, C.J. Isaac, K.J. Sanders and A. Rodger, Angew. Chem., Intl. Ed., 2001, 40, 879-884. DOI 10.1002/1521-3773(20010302)40:5<879::AID-ANIE879>3.0.CO;2-X

Estrogen derived steroidal metal complexes; agents for cellular delivery of metal centres to estrogen receptor-positive cells, M. Hannon, A. Jackson, J. Davis, R.J. Pither and A. Rodger, J. Inorg. Biochem., 2001, 86, 247.

Intramolecular DNA ceiling mediated by a metallo-supramolecular cylinder that targets the major groove, M. Hannon, I. Meistermann, C.J. Isaac, A. Rodger, V. Moreno, M.J. Prieto, E. Sletten and E. Moldrheim, J. Inorg. Biochem., 2001, 86, 56.

Kinky supramolecular chemistry - grabbing the DNA major groove, I. Meistermann, A. Rodger, M.J. Hannon, V. Moreno, M.J. Prieto, E. Sletten and E. Moldrheim, J. Inorg. Biochem., 2001, 86, 335.

Synthesis and characterisation of water soluble poly (aryl ether) dendrimers for encapsulation of biomimetic active site analogues,M.J. Hannon, P.C. Mayers and P.C. Taylor, J. Chem. Soc., Perkin Trans. I, 2000, 1881-1889. DOI: 10.1039/b002026p                                    

DNA structure control by polycationic species: polyamines, cobalt ammines and di-metallo transition metal chelates, A. Rodger, K.J. Sanders, M.J. Hannon, I. Meistermann, A. Parkinson, D.S. Vilder and I.S. Haworth, Chirality, 2000, 12, 221-236.

Red and blue luminescent metallo-supramolecular coordination polymers assembled through π-π interactions, N.W. Alcock, P.R. Barker, J.M. Haider, M.J. Hannon, C.L. Painting, Z. Pikramenou, E.A. Plummer, K. Rissanen and P. Saarenketo, J. Chem. Soc., Dalton Trans., 2000, 1447-1461. DOI: 10.1039/b000871k

Synthesis and co-ordination chemistry of 4',4"-disubstituted 2,2':6',2":6",2'"-quaterpyridines and crystal and molecular structures of nickel(II) and cobalt(II) complexes, E.C. Constable, M.J. Hannon, P. Haverson, M. Neuburger, D.R. Smith, V.F. Wanner, L.A. Whall and M. Zehnder, Polyhedron, 2000, 19, 23-34. DOI 10.1016/S0277-5387(99)00318-6

A metallo-supramolecular double helix containing a major and a minor groove, M.J. Hannon, C.L. Painting and N.W. Alcock, Chem. Commun., 1999, 2023-2024.DOI: 10.1039/a905795a

Spacer control of directionality in supramolecular helicates using an inexpensive approach, M.J. Hannon, S. Bunce, A.J. Clarke and N.W. Alcock, Angew. Chem., Intl. Ed., 1999, 38, 1277-1278.  DOI 10.1002/(SICI)1521-3773(19990503)38:9%3C1277::AID- ANIE1277%3E3.3.CO%3B2-4                                                                                         

Atom transfer polymerization: Use of uridine and adenosine derivatized monomers and initiators, A. Marsh, A. Khan, D.M. Haddleton, M.J. Hannon, Macromolecules, 1999, 32, 8725-8731. DOI: 10.1021/ma991438q

Hydrogen bond template-directed polymerization of protected 5'-acryloylnucleosides, A. Khan, D.M. Haddleton, M.J. Hannon, D. Kukulj, A. Marsh, Macromolecules, 1999, 32, 6560-6564. DOI: 10.1021/ma990283j

Heteroleptic ruthenium complexes containing quinquepyridine and its derivatives, E.C. Constable, C.J. Cathey, M.J. Hannon, D.A. Tocher, J.V. Walker and M.D. Ward, Polyhedron, 1999, 18, 159-173. DOI 10.1016/S0277-5387(98)00280-0

Preparation of substituted tris(2-pyridyl) methanol derivatives as mimics of the metal binding site of carbonic anhydrase, M.J. Hannon, P.C. Mayers and P.C. Taylor, Tetrahedron Lett., 1998, 39, 8509-12. DOI 10.1016/S0040-4039(98)01850-4

Silver(I)-2,2':6',2"-terpyridine complexes, E.C. Constable, A.J. Edwards, G.R. Haire, M.J. Hannon and P.R. Raithby, Polyhedron, 1998, 17, 243-253. DOI 10.1016/S0277-5387(97)00333-1

An inexpensive approach to supramolecular architecture, M.J. Hannon, C.L. Painting, J. Hamblin, A. Jackson and W. Errington, Chem. Commun., 1997, 1807-1808.DOI: 10.1039/a703713i

Controlled aggregation of supramolecular boxes, M.J. Hannon, C.L. Painting and W. Errington, Chem. Commun., 1997, 1805-1806. DOI: 10.1039/a703646i

Self assembly of supramolecular boxes, M.J. Hannon, C.L. Painting and W. Errington, Chem. Commun., 1997, 307-308.        DOI: 10.1039/a607826e

Atom transfer living polymerisation of methyl methacrylate initiated by alkyl bromide and 2-pyridinecarbaldehydeimine copper(I) complexes, D.M. Haddleton, C.B. Jasieczek, M.J. Hannon and A.J. Shooter, Macromolecules, 1997, 30, 2190-2193. DOI: 10.1021/ma961074r

Polymerisation of styrene using a soluble copper(I) compound in conjunction with an alkyl bromide, D.M. Haddleton, A.J. Shooter, M.J. Hannon and J.A. Barker, ACS Polymer Preprints, 38(1), 1997, 213, No. Pt2, 316-POLY.

Rhodium 1994, M.J. Hannon, Coord. Chem. Revs., 1997, 162, 477-494.DOI 10.1016/S0010-8545(96)01336-7

Iridium 1994, M.J. Hannon, Coord. Chem. Revs., 1996, 152, 393-409. DOI 10.1016/0010-8545(96)01277-5

2,2':6',2":6",2"'-Quaterpyridine - A versatile ligand in metallosupramolecular chemistry, E.C. Constable, S.M. Elder, M.J. Hannon, A. Martin, P.R. Raithby and D.A. Tocher, J. Chem. Soc., Dalton Trans., 1996, 2423-2433.  DOI: 10.1039/DT9960002423                                        

Hypodentate ligands; systematic approaches to complexes containing didentate 2,2':6',2"-terpyridine ligands, R.C. Chotalia, E.C. Constable, M.J. Hannon and D.A. Tocher, J. Chem. Soc., Dalton Trans., 1995, 3571-3580.  DOI: 10.1039/DT9950003571                                 

Cinnamil - An oligopyridine precursor, E.C. Constable, M.J. Hannon, and D.R. Smith, Tetrahedron Lett., 1994, 35, 6657-6660. DOI 10.1016/S0040-4039(00)73460-5

Metallosupramolecular assembly of dinuclear double-helicates incorporating a biphenyl-3,3'-diyl spacer, E.C. Constable, M.J. Hannon, A.J. Edwards and P.R. Raithby, J. Chem. Soc., Dalton Trans., 1994, 2669-2677. DOI: 10.1039/DT9940002669

Double-helical complexes from simple 2,2':6',2"-terpyridines, E.C. Constable, A.J. Edwards, M.J. Hannon and P.R. Raithby, J. Chem. Soc., Chem. Commun., 1994, 1991-1992. DOI: 10.1039/C39940001991

A principle for the assembly of novel mononuclear building blocks for supramolecular chemistry, E.C. Constable, M.J. Hannon, A.M.W. Cargill Thompson, D.A. Tocher and J.V. Walker, Supramol. Chem., 1993, 2, 243-246. DOI: 10.1080/10610279308038322                                      

Solvent effects in the reactions of 6-phenyl-2,2'-bipyridine with ruthenium (II), E.C. Constable and M.J. Hannon, Inorg. Chim. Acta, 1993, 211, 101-110. DOI 10.1016/S0020-1693(00)82850-9

Dinuclear double-helicates incorporating a 1,3-phenylene spacer, E.C. Constable, M.J. Hannon and D.A. Tocher, J. Chem. Soc., Dalton Trans., 1993, 1883-1890.DOI: 10.1039/DT9930001883

Self-assembly of double-helical complexes of 2,2':6',2":6",2"'-quaterpyridine (qtpy), E.C. Constable, M.J. Hannon, A. Martin, P.R. Raithby and D.A. Tocher, Polyhedron, 1992, 11, 2967. DOI 10.1016/S0277-5387(00)83604-9

Spontaneous self-assembly of a dinickel (II) double helicate containing a 1,3-benzenediyl spacer group, E.C. Constable, M.J. Hannon and D.A. Tocher, Angew. Chem. Intl. Ed., 1992, 31, 230-232. DOI 10.1002/anie.199202301

A single stranded diruthenium (II) complex, C.J. Cathey, E.C. Constable, M.J. Hannon, D.A. Tocher and M.D. Ward, J. Chem. Soc., Chem. Commun., 1990, 621-623. DOI: 10.1039/C39900000621

Published Patents

PCT/GB2008/003967   Dinuclear, Quadruply-stranded compounds comprising palladium or platinum (and their use to treat cancer, microbial and vira infections) M.J. Hannon,WIPO link (Published 4 June 2009)

PCT/GB2004/004227 Supramolecular compounds and their use as antitumour and anitviral agents, M.J.Hannon, A. Rodger, N.H. Mann. WIPO link (Published 14 April 2005)    (Granted GB2425122B)   

PCT/GB01/03739 Use of a porous carrier to carry drugs, R.M. Sambrook, W. Austin, M.R. Sambrook and M.J. Hannon. WIPO link (Granted)

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